EpiCast Report: Gram-Negative Bacterial Urinary Tract Infection – Epidemiology Forecast to 2022

Publisher Name :
Date: 15-Nov-2013
No. of pages: 54

Urinary tract infections (UTIs) are among the most common bacterial infections acquired in hospitals and in the community setting. A UTI can occur when daily living activities and medical interventions aid in the movement of bacteria into the urethra; however, bacterial colonization does not always lead to the development of UTI symptoms. Although UTIs can be caused by bacteria, viruses, or fungi, gram-negative bacteria are the pathogens most frequently associated with UTIs. Gram-negative bacteria have become increasingly resistant to individual antimicrobials, and of particular concern, is the emergence of multidrug-resistant activity in these organisms. Although there has been little change in the predominant causative pathogens in the past few decades, individual pathogen frequency and resistance patterns of gram-negative pathogens vary considerably between settings, countries, and continents.

According to GlobalData’s forecast, the number of incident cases of UTI will increase in the US during the forecast period. The largest number of cases will be classified as community-acquired and occur in women =80 years of age. The 5EU will see a slight increase in the number of healthcare-associated incident cases of UTI during the forecast period, with the highest number of cases occurring among women in Germany, and among those ages 70-79 years. Japan is forecast to see a large increase in the number of incident cases of UTI occurring during the forecast period in intensive care units, with the greatest number of cases occurring among women and those =80 years.

A major strength of this analysis is that GlobalData epidemiologists used country-specific sources for each market in the analysis and were able to obtain country-specific national surveillance data for the 5EU and Japan. The use of country-specific sources is especially important for antimicrobial resistance data as the rates of resistance have been found to vary considerably between countries. Additionally, because resistance rates have changed over time, GlobalData’s use of recent sources for resistance rates ensures that the estimates for the number of resistant cases of UTI reflect the most current situation in each market.

Scope

  • The Gram-Negative Bacterial Urinary Tract Infection (UTI) EpiCast Report provides an overview of the risk factors and global trends of UTI in the 7MM (US, France, Germany, Italy, Spain, UK, and Japan). It includes a 10-year epidemiology forecast of UTI incident cases segmented by age (0-85 years and older), sex, causative pathogen (Escherichia coli, Klebsiella, Pseudomonas aeruginosa, Proteus, and Acinetobacter), multidrug resistance, and carbapenem resistance in these markets.
  • The UTI epidemiology report is written and developed by Mastersand PhD-level epidemiologists.
  • The EpiCast Report is in-depth, high quality, transparent and market-driven, providing expert analysis of disease trends in the 7MM.

Reasons to buy

  • Develop business strategies by understanding the trends shaping and driving the global UTI market.
  • Quantify patient populations in the global UTI market to improve product design, pricing, and launch plans.
  • Organize sales and marketing efforts by identifying the sex, age groups, pathogens, and antibiotic resistance patterns that present the best opportunities for UTI therapeutics in each of the markets covered.

EpiCast Report: Gram-Negative Bacterial Urinary Tract Infection – Epidemiology Forecast to 2022

Table Of Contents

1 Table of Contents
1 Table of Contents 4
1.1 List of Tables 5
1.2 List of Figures 6

2 Introduction 7
2.1 Catalyst 7
2.2 Related Reports 8
2.3 Upcoming Reports 8

3 Epidemiology 9
3.1 Disease Background 9
3.2 Risk Factors and Comorbidities 10
3.2.1 Women are more likely than men to experience UTI at all ages 11
3.2.2 The risk of developing UTI increases 3%-6% per day of catheterization 11
3.2.3 Older age is a major risk factor for UTI 12
3.2.4 Sexual intercourse can increase the relative odds of UTI in women by a factor as high as 60 13
3.2.5 Diabetic individuals have an increased incidence of UTI and increased associated complications 13
3.3 Forecast Methodology 14
3.3.1 Sources Used 15
3.3.2 Forecast Assumptions and Methods 19
3.4 Epidemiological Forecast for UTI (2012-2022) 24
3.4.1 US 24
3.4.2 5EU 29
3.4.3 Japan 36
3.5 Discussion 41
3.5.1 Conclusions on Epidemiological Trends 41
3.5.2 Limitations of the Analysis 42
3.5.3 Strengths of the Analysis 43

4 Appendix 44
4.1 Bibliography 44
4.2 About the Authors 49
4.2.1 Epidemiologists 49
4.2.2 Reviewers 49
4.2.3 Franka des Vignes, PhD, Global Director of Epidemiology and Health Policy 51
4.2.4 Bonnie Bain, PhD, Global Head of Healthcare 51
4.3 About GlobalData 52
4.4 About EpiCast 52
4.5 Disclaimer 53

List of Tables

Table 1: Risk Factors for Urinary Tract Infection 11
Table 2: Sources of Incidence Data Used in the Epidemiology Forecast 14
Table 3: US, Incident Cases of Gram-Negative UTI, N, by Site of Acquisition, Select Years, 2012-2022 25
Table 4: US, Incident Cases of Gram-Negative UTI, by Age and Site of Acquisition, N (Row %), 2012 26
Table 5: US, Incident Cases of Gram-Negative UTI, by Sex and Site of Acquisition, N (Row %), 2012 27
Table 6: US, Incident Cases of Gram-Negative UTI, by Pathogen and Site of Acquisition, N (Column %), 2012 28
Table 7: US, Incident Cases of Gram-Negative UTI, by Pathogen and Multidrug* and Carbapenem† Resistance, N, Percentage of Pathogen-Specific Cases, 2012 29
Table 8: 5EU, Incident Cases of UTI, N, Select Years, 2012-2022 30
Table 9: 5EU, Incident Cases of UTI, by Age, N (Row %), 2012 31
Table 10: 5EU, Incident Cases of UTI, by Sex, N (Row %), 2012 32
Table 11: 5EU, Incident Cases of UTI, by Pathogen, N (Percentage of Total Country-Specific Cases Caused by Pathogen), 2012 33
Table 12: 5EU, Incident Cases of UTI, by Pathogen and Multidrug and Carbapenem Resistance, N, and Percentage of Pathogen-Specific Cases, 2012 35
Table 13: Japan, Incident Cases of UTI, N, Select Years, 2012-2022 36
Table 14: Japan, Incident Cases of UTI, by Age, N (Row %), 2012 37
Table 15: Japan, Incident Cases of UTI, by Sex, N (Row %), 2012 38
Table 16: Japan, Incident Cases of UTI, by Pathogen, N (Percentage of Total Country-Specific Cases Caused by Pathogen), 2012 39
Table 17: Japan, Incident Cases of UTI, by Pathogen and Antibiotic, Number of Antibiotic-Resistant Cases (N) and Percentage of Antibiotic-Resistant Pathogen-Specific Cases (%), 2012 40

List of Figures

Figure 1: US, Incident Cases of Gram-Negative UTI, N, by Site of Acquisition, Select Years, 2012-2022 25
Figure 2: US, Incident Cases of Gram-Negative UTI, by Age and Site of Acquisition, N, 2012 26
Figure 3: US, Incident Cases of Gram-Negative UTI, by Sex, N, 2012 27
Figure 4: US, Incident Cases of Gram-Negative UTI, by Pathogen and Site of Acquisition, N, 2012 28
Figure 5: 5EU, Incident Cases of UTI, N, Select Years, 2012-2022 30
Figure 6: 5EU, Incident Cases of UTI, by Age, N, 2012 31
Figure 7: 5EU, Incident Cases of UTI, by Sex, N, 2012 32
Figure 8: 5EU, Incident Cases of UTI, by Pathogen, N, 2012 34
Figure 9: Japan, Incident Cases of UTI, N, Select Years, 2012-2022 36
Figure 10: Japan, Incident Cases of UTI, by Age, N, 2012 37
Figure 11: Japan, Incident Cases of UTI, by Sex, N, 2012 38
Figure 12: Japan, Incident Cases of UTI, by Pathogen, N, 2012 39

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