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RNAi Technologies and Global Markets

Publisher Name :
Date: 18-Jan-2016
No. of pages: 176

Report Scope:

BCC Research conducted the market assessment, the global and regional breakdown of sales data, market projection for the commercial RNAi technologies, application of the techniques in commercial sector as well as in research and development. Further, BCC Research offers the details of new developments, patent analysis, market leaders and market share, etc. for the RNAi technologies and its applications.

The report summarizes the global RNAi technologies market by category and by region. The RNAi market is analyzed based on RNAi research tools and reagents as well as on RNAi diagnostics. The research tools and reagents and therapeutics considered in this report are mainly for small/short interfering RNAs (siRNAs) and diagnostics are mainly based on microRNAs (miRNAs).

MicroRNA (miRNA) research tools, services, drug discovery etc. are excluded from this report; however, these areas are worth a separate report and thus are analyzed in BCC Research report BIO115B in detail. U.S. and non-U.S. markets are considered for the geographical market analysis. The prospective application of RNAi therapeutics in various disease classifications such as oncological, cardiovascular, neurodegenerative, ophthalmologic and others are discussed. The application and progress of RNAi technologies in agriculture is also discussed in this report.

BCC Research verified the sales data for the global and regional RNAi markets for the present and projected values through statistical analysis. The tools/technology details in the report are based on their present and their prospective application and suitability.

Report Includes:

- An overview of the global market for RNAi technologies which are used in the areas of drug delivery, therapeutics, and diagnostics

- Analyses of global market trends, with data from 2014, estimates for 2015, and projections of compound annual growth rates (CAGRs) through 2020

- A breakdown of the technologies: RNAi for drug delivery (by nanoparticle delivery, nucleic acid delivery, aptamer delivery); RNAi for drug discovery and therapeutics (by diseases); RNAi for disease diagnostics and biomarker development (by diseases); and RNAi for reagents, research tools, and other applications (by application)

- Examination of significant deals in the RNAi technologies sector during the last decade

- A look at commercial opportunities in the RNAi research tools and reagents, drug development, diagnostic, and agriculture markets

- Profiles of major players in the industry

REASONS FOR DOING THIS STUDY

The RNAi market is burgeoning and is one of the most watched markets in the pharmaceuticals industry. The reason for this status is the encouraging application of RNAi mechanisms in therapeutics through gene silencing. There is no approved therapy so far; however, various candidates have shown successful results in their clinical investigations. The report reflects the details of those candidates along with prospective applications of RNAi in diagnostics and agriculture. This market will grow through 2020 with the successful utilization of techniques in both therapeutics and agriculture.

SCOPE OF THE STUDY

BCC Research conducted the market assessment, the global and regional breakdown of sales data, market projection for the commercial RNAi technologies, application of the techniques in commercial sector as well as in research and development. Further, BCC Research offers the details of new developments, patent analysis, market leaders and market share, etc. for the RNAi technologies and its applications.

The report summarizes the global RNAi technologies market by category and by region. The RNAi market is analyzed based on RNAi research tools and reagents as well as on RNAi diagnostics. The research tools and reagents and therapeutics considered in this report are mainly for small/short interfering RNAs (siRNAs) and diagnostics are mainly based on microRNAs (miRNAs).

MicroRNA (miRNA) research tools, services, drug discovery etc. are excluded from this report; however, these areas are worth a separate report and thus are analyzed in BCC Research report BIO115B in detail. U.S. and non-U.S. markets are considered for the geographical market analysis. The prospective application of RNAi therapeutics in various disease classifications such as oncological, cardiovascular, neurodegenerative, ophthalmologic and others are discussed. The application and progress of RNAi technologies in agriculture is also discussed in this report.

BCC Research verified the sales data for the global and regional RNAi markets for the present and projected values through statistical analysis. The tools/technology details in the report are based on their present and their prospective application and suitability.

RNAi Technologies and Global Markets

Table of Contents

Chapter 1 Introduction
Study Objectives
Reasons For Doing This Study
Contributions of the Study and Intended Audience
Scope of the Study
Methodology
Information Sources
Analyst Credentials
Related Bcc Research Reports
Bcc Research Website
Disclaimer

Chapter 2 Executive Summary

Chapter 3 Overview
Ribonucleic Acid (Rna)
Evolution of Rna
Rna Interference (Rnai)
Mechanism of Action of Rna Interference
Rna Interference Drug Delivery
Systemic Elimination of Sirna
Sirna Stability In Bloodstream
Reticuloendothelial System (Res) Entrapment
Vascular Endothelium
Diffusion
Plasma Membrane
Endosomal Entrapment
Nano-Carrier Mediated Toxicity
Methods of Rna Interference Drug Delivery Systems
Rnai Drug Discovery and Development
Rna-Based Therapies
Other Potential Applications of Rna Interference
Diagnostics
Agriculture

Chapter 4 New Developments and Regulatory Activity
New Developments
Regulatory Aspects
Regulatory Developments
Collaborative Trials and Future Activities

Chapter 5 Market Analysis
Market By Technology
Market Share
Rna Interference Research Tools and Reagents
Rnai Interference Therapeutics
Global Pharmaceutical Market
Rnai Diagnostics
Rna Interference In Agriculture
Market By Region
Market Overview
Market Revenue

Chapter 6 Industry Structure
Rnai Research Tools and Reagents
Market Leaders
Market Shares
Rnai Diagnostics
Market Leaders
Market Shares

Chapter 7 Patent Analysis
Patents By Year
Patents By Country For Rna Interference Technologies
Patents By Company For Rna Interference Technologies
Patents By Assignee For Rna Interference Technologies

Chapter 8 Current Status
Innovative Technologies and Platforms For Rna Interference
Dynamic Polyconjugate (Dpc) Platform-Arrowhead Research Corp.)
Conjugate Delivery Platforms - Esc-Galnac-Conjugate (Alnylam Pharmaceuticals Inc.)
Lipid Nanoparticle (Lnp) Technology (Arbutus Biopharma Corp)
Sirna Technology Platform (Quark Pharmaceuticals Inc.)
Modified Messenger Rna Therapeutics Platform (Moderna Therapeutics)
Rnai Technology Platforms (Ge Dharmacon)
Rnai Technologies (Thermo Fisher Scientific)
Rnai Tools From Sigma-Aldrich
Locked Nucleic Acid (Lna) Platform (Roche [Santaris Pharma])
Trifecta Rnai Kit (Integrated Dna Technologies)
Psitest System (Invivogen)
Self-Deliverable Rnai Technology (Advirna)
Rnai Technologies (Bioneer Corp)
Pooled Lentiviral Libraries (Cellecta Inc.)
Nanoparticle-Drug Conjugates (Ndcs) (Cerulean Pharma Inc.)
Allstars Rnai Controls (Qiagen N.V.)
Rnai Technologies (Applied Biological Materials)
Lipid-Enabled and Unlocked Nucleic Acid Modified Rna Delivery Technology (Arcturus Therapeutics, Inc.)
Elastin-Like Polypeptide (Elp) Nanoparticles (Peptimed Inc.)
Microrna-Based Diagnostic Tests (Rosetta Genomics)
Aturnai (Silence Therapeutics)
Dsirna-Ex-Conjugates (Dicerna Pharmaceuticals Inc.)
Loder (Silenseed Ltd.)
Factors Affecting the Rna Interference Market
Current Drivers For the Rna Interference Technology Market
Merger and Acquisition Activities
Funding For Development of Rna Interference Therapeutics and Technologies

Chapter 9 Company Profiles
Advirna
Alnylam Pharmaceuticals, Inc.
Apeiron Biologics Ag
Applied Biological Materials, Inc.
Arbutus Biopharma Corp. (Previously Tekmira Pharmaceuticals Corp.)
Arcturus Therapeutics, Inc.
Arrowhead Research Corp.
Ascletis Inc.
Benitec Biopharma Ltd.
Biogen Idec, Inc.
Biomics Biotechnologies Co. Ltd.
Bioneer Corp.
Cellecta, Inc.
Cerulean Pharma, Inc.
Dicerna Pharmaceuticals, Inc.
Exiqon A/S
F. Hoffmann-La Roche Ag (Roche)
General Electric Co.
Integrated Dna Technologies, Inc.
Invivogen
Isis Pharmaceuticals, Inc.
Marina Biotech, Inc.
Moderna Therapeutics
Monsanto Co.
Nitto Denko Corp.
Peptimed Inc.
Qiagen N.V.
Quark Pharmaceuticals, Inc.
Regulus Therapeutics
Rosetta Genomics Ltd.
Rxi Pharmaceuticals Corp.
Sanofi
Sigma-Aldrich
Silence Therapeutics Plc.
Silenseed Ltd.
Solstice Biologics
Somagenics, Inc.
Sumitomo Dainippon Pharma Co. Ltd.
Syngenta International Ag
The National Institutes of Health (Nih)
The Rnai Consortium At Broad Institute of Mit and Harvard
The University of Texas Md Anderson Cancer Center
Thermo Fisher Scientific, Inc.
Zeltia Group

Chapter 10 Appendix
Glossary and Abbreviations

List of Tables
Summary Table : Global Revenue For Rna Interference Technologies By Type, Through 2020
Table 1 : Evolution of Rna
Table 2 : Microrna (Mirna) Databases
Table 3 : Short/Small Interfering Rna (Sirna) Databases
Table 4 : Piwi-Interacting Rna (Pirna) Databases
Table 5 : Stabilization Methods For Lipid Based Sirna Delivery System
Table 6 : New Developments In the Research Pipeline of Rnai Therapeutics and Technologies As of September 2015
Table 7 : Global Revenue For Rnai Technologies By Type, Through 2020
Table 8 : Market Share of Rnai Technologies By Type, 2014
Table 9 : Modifications of Sirna
Table 10 : Rnai Vectors
Table 11 : Global Revenue For Rnai Research Tools and Reagents, Through 2020
Table 12 : Market Share of Rnai Research Tools and Reagents, 2014
Table 13 : Disease-Specific Target Genes/Proteins For Rnai Therapeutics
Table 14 : Global Pharmaceutical Market, Through 2020
Table 15 : Global Pharmaceutical Market Shares By Region, 2014
Table 16 : Top Global Pharmaceutical Companies By Sales, 2014
Table 17 : Global Outlook of Therapeutic Spending By Disease, Through 2018
Table 18 : Number of Publications Associated With Mirna and Diseases, October 2015
Table 19 : Mirna In Various Cancer Types
Table 20 : Mirna and Target Gene Pairs In Various Cancer Types
Table 21 : Biomarkers In Various Cancer Types
Table 22 : Global Revenue Market For Rnai Diagnostics, Through 2020
Table 23 : Global Revenue For Mirna Research Tools, Through 2020
Table 24 : Safety Issues With Rnai Crop Improvement
Table 25 : Plant Improvement Areas Through Rnai Technologies
Table 26 : Regions, Genes and Application of Rnai-Targeting Organisms For Improvement of Crops
Table 27 : Global Revenue For Rnai Research Tools and Reagents By Region, Through 2020
Table 28 : Global Market Share of Rnai Research Tools and Reagents By Region, 2014
Table 29 : Global Revenue For Rnai Diagnostics By Region, Through 2020
Table 30 : Global Market Share of Rnai Diagnostics By Region, 2014
Table 31 : Leading Manufacturers/Suppliers of Rnai Research Tools and Reagents, 2014
Table 32 : Global Market Shares of Manufacturers/Suppliers For Rnai Research Tools and Reagents, 2014
Table 33 : Leading Manufacturers/Suppliers of Rnai Diagnostics, 2014
Table 34 : Market Shares of Manufacturers/Suppliers For Rnai Diagnostics, 2014
Table 35 : Total Number of Patents By Year, 2013-August 2015
Table 36 : Number of U.S. Patents For Rnai Technologies By Country, 2013-August 2015
Table 37 : Patent Shares For Rnai Technologies By Country, 2013-August 2015
Table 38 : Number of U.S. Patents For Rnai Technologies By Company, 2013-August 2015
Table 39 : Number of Patents For Rnai Technologies By Type of Assignee, 2013-August 2015
Table 40 : Funding For Development of Rnai-Based Products and Platforms, 2013-September 2015
Table 41 : Investments For Development of Rnai-Based Products and Platforms, 2013-September 2015

List of Figures
Summary Figure : Global Revenue For Rna Interference Technologies By Type, 2013-2020
Figure 1 : Global Revenue For Rnai Technologies By Type, 2013-2020
Figure 2 : Market Share of Rnai Technologies By Type, 2014
Figure 3 : Global Revenue For Rnai Research Tools and Reagents, 2013-2020
Figure 4 : Market Share of Rnai Research Tools and Reagents, 2014
Figure 5 : Global Pharmaceutical Sales Market,2013-2020
Figure 6 : Global Pharmaceutical Market Shares By Region, 2014
Figure 7 : Global Revenue Market For Rnai Diagnostics, 2013-2020
Figure 8 : Global Revenue For Mirna Research Tools,2013-2020
Figure 9 : Global Revenue For Rnai Research Tools and Reagents By Region, 2013-2020
Figure 10 : Global Market Share of Rnai Research Tools and Reagents By Region, 2014
Figure 11 : Global Revenue For Rnai Diagnostics By Region, 2013-2020
Figure 12 : Global Market Share of Rnai Diagnostics By Region, 2014
Figure 13 : Global Market Shares of Manufacturers/Suppliers For Rnai Research Tools and Reagents, 2014
Figure 14 : Market Shares of Manufacturers/Suppliers For Rnai Diagnostics, 2014
Figure 15 : Total Number of Patents By Year, 2013-August 2015
Figure 16 : Patent Shares For Rnai Technologies By Country, 2013-August 2015
Figure 17 : Number of Patents For Rnai Technologies By Type of Assignee, 2013-August, 2015
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