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RNA Sequencing: Technologies and Global Markets

Publisher Name :
Date: 04-Mar-2016
No. of pages: 135

Report Scope:

The geographic scope is global. The RNA-Seq market is complex, consisting of a number of different segments. The market segments are: RNA-Seq instruments; RNA-Seq tools and reagents; RNA-Seq data analysis and RNA-Seq services. Each segment is affected differently by technological and regulatory developments. This report identifies the main factors affecting each segment and forecasts market growth, future trends and product development in every major market segment. Market forecasts are given for the years 2015, 2016 and 2020.

The report is organized by presenting the core segment (sequencing instruments) first, followed by its derivative segments (tools and reagents, data analysis, services). The development of sequencing instruments is vital for RNA-Seq development; thus sequencing instruments segment is classified as the core segment. However, it does not suggest that the derivative segments are not important. In fact, the RNA-Seq instruments segment is neither the biggest nor the fastest growing among the four segments. The instruments segment, however, provides the infrastructure for the health and growth of the RNA-Seq market as a whole.

Report Includes:

- An overview of the global markets for RNA sequencing and related technologies.

- Analyses of global market trends, with data from 2015, estimates for 2016, and projections of CAGRs through 2020.

- Analysis of RNA sequencing clinical application initiatives.

- Evaluation of collaboration and merger and acquisition activity.

- A look at the regulatory environment and its effect on the market.

- Analyses of the market's dynamics, specifically growth drivers, restraints, and opportunities.

- Identification of patents with the potential to make an impact in the RNA sequencing industry.

- Profiles of major players in the industry.

REASONS FOR DOING THE STUDY

RNA-Seq, introduced around 2010, is a method for transcriptomics. In a few short years, it has become the method of choice for transcriptome studies, rapidly replacing another transcriptomics method; the microarray. Transcriptomics is the study of transcriptome, the complete set of RNA transcripts that are produced by the genome, under specific circumstances or in a specific cell, using high-throughput methods. RNA-Seq not only provides benefits to the scientific research community, but also has huge clinical potential in diagnostics and drug discovery. The RNA-Seq industry is an emerging, evolving and important biomedical sector; a comprehensive and critical study about its technologies and markets is needed for better understanding.

RNA Sequencing: Technologies and Global Markets

Table of Contents

Chapter 1 Introduction
Study Goals and Objectives
Reasons For Doing the Study
Intended Audience
Scope and Format
Methodology and Information Sources
Analyst's Credentials
Related Bcc Research Reports
Bcc Research Website
Disclaimer

Chapter 2 Summary

Chapter 3 Introduction On Rna-Seq
Transcriptomics
Technologies For Transcriptomics
Rna-Seq For Transcriptomics
Rna-Seq Experiment
Experimental Design
Rna Sample Preparation
Library Preparation
High-Throughput Sequencing
Data Analysis
Challenges For Rna-Seq
Library Construction Challenges
Bioinformatic Challenges
Cost Versus Coverage Challenges
Rna-Seq Insights and Applications
Mapping Gene and Exon Boundaries
Extensive Transcript Complexity
Novel Transcription
Defining Transcription Level
Future Direction

Chapter 4 Rna-Sequencing Instruments
Overview
Sequencing Technologies For Rna-Seq
Notable Rna-Seq Platforms
Sequencing Platforms To Watch
Technology and Rna-Seq On Illumina Platforms
Sbs Sequencing Technology
Sequencing Workflow
Rna-Seq Applications On Illumina Sequencing Platforms
Technologies and Rna-Seq On Thermo Fisher Platforms
Sanger Sequencing
Ion Torrent Technology
Rna-Seq On Ion Torrent Platforms
Solid Sequencing Platform
Technologies and Rna-Seq On Pacbio Platforms
Smrt Technology
Rna-Seq Applications On Pacbio Platforms
Rna-Seq Applications On 454 Platforms
Cdna Rapid Library Prep
Low-Input Rna Samples
Other Commercial Sequencing Platforms
Bgi (Complete Genomics)
Genepsys
Oxford Nanopore
Qiagen (Intelligent Biosystems)
New Sequencing Technologies and Rna-Seq Applications
Genia
Base4 and Hitachi
Gnubio/Bio-Rad
Nabsys
Stratos Genomics
Two Pore Guys
Market Share of Each Platform
Rna-Seq Instrument Market Projection
Market Trends

Chapter 5 Rna-Seq Tools and Reagents
Overview
Market Landscape
Rna-Seq Automation
Neoprep From Illumina
Rem E System From Roche
Ion Torrent Ion Chef System From Thermo Fisher
Solid Ez Bead System From Thermo Fisher
C1 System From Fluidigm
Qiacube From Qiagen
Rna-Seq Sample Preparation
Rna Sample Isolation and Purification
Rna Concentration and Purity Determination
Rna Sample Quality Control
Rna Depletion Or Enrichment
Rrna Depletion
Mrna Enrichment
Rna-Seq Library Preparation
Rna-Seq Library Prep Kits From Illumina
Rna-Seq Library Prep Products From Thermo Fisher
Rna-Seq Library Prep Kits From Roche 454
Rna-Seq Library Prep Kits From Pacbio Platform
Rna-Seq Products From New England Biolabs
Rna-Seq Library Preparation Products From Kapa Biosystems
Rna-Seq Products From Clontech (Takara)
Rna-Seq Products From Agilent
Rna-Seq Products From Qiagen
Rna-Seq Reagents From Nimblegen (Roche)
Market Analysis

Chapter 6 Rna-Seq Data Analysis
Overview
Rna-Seq Data Analysis Challenges
Data Solution
Alignment and Annotation
Data Analysis For Long-Read Sequencers
Rna-Seq Data Cloud Services
Stand-Alone Tools For Rna-Seq Data Analysis
Rna-Seq Data Analysis On Illumina Platforms
Basespace
Rna-Seq Data Analysis On Other Platforms
Rna-Seq Data Analysis On Ion Torrent Platforms
Rna-Seq Data Analysis On Solid Platforms
Rna-Seq Data Analysis On 454 Platforms
Rna-Seq Data Analysis On Pacbio Platforms
Rna-Seq Data Analysis Market Analysis

Chapter 7 Rna-Seq Service Market
Overview
Platform-Specific Certified Service Providers
Illumina Certified Service Providers (Cspro)
Ion Torrent Certified Service Provider Program
Solid Next-Generation Sequencing Analysis Services
Nimblegen Certified Service Providers On 454 Platforms
Pacific Biosciences (Pacbio) Certified Service Providers
Agilent's Certified Service Providers-Target Enrichment
Non-Certified Service Providers
Notable Service Providers
Ambry Genetics
Baseclear
Beckman Coulter Genomics
Bgi
Cegat
Dna Link
Dnavision
Exiqon A/S
Expression Analysis (Q2 Solutions)
Fasteris
Gatc
Genewiz
Integragen
Perkinelmer Inc
Seqll
Seqwright (Now Ge Healthcare)
Market Analysis

Chapter 8 Company Profiles
Agilent Technologies Inc.
Amazon.Com Inc.
Bgi
Bio-Rad
Dnanexus Inc.
General Electric Company
Illumina Inc.
New England Biolab Inc.
Oxford Nanopore Tehnologies Ltd.
Pacific Biosciences of California Inc.
Qiagen Nv
Roche Holding Ag
Takara Bio Inc.
Thermo Fisher Scientific Inc.

Chapter 9 Companiies Profile

List of Tables
Summary Table : Global Rna-Seq Market By Segment, Through 2020
Table 1 : Types of Rnas In Cells
Table 2 : Transcriptomics Insights
Table 3 : Comparison of Transcriptomics Methods
Table 4 : Rna-Seq Annotation/Dge Options
Table 5 : Functional Elements In Sequencing Adapters
Table 6 : Fragmentation Methods and Bias
Table 7 : Illumina Sequencing Instruments
Table 8 : Thermo Fisher Sequencing Instruments
Table 9 : Roche Sequencing Instruments
Table 10 : Pacbio Sequencing Instruments
Table 11 : Significant Players In Sequencing Market
Table 12 : Workflow Steps For Sequencing System
Table 13 : Rna-Seq Applications On Illumina Platforms
Table 14 : Mrna-Seq On Illumina Platforms
Table 15 : Total Rna-Seq On Illumina Platforms
Table 16 : Recommended Setup For Targeted Rna-Seq On Miseq Platforms
Table 17 : Small Rna-Seq On Illumina Platforms
Table 18 : Ribosomal Profiling On Illumina Platforms
Table 19 : Rna-Seq Applications On Ion Systems
Table 20 : Solid 5500 Sequencing Platform Performances
Table 21 : Pacbio Rna-Seq Applications
Table 22 : Pacbio Rna-Seq Workflow
Table 23 : Workflow For 454 Sequencer
Table 24 : High-Throughput Instrument Competitors By Installed Instrument Base, As of December 2015
Table 25 : Benchtop Instrument Competitors By Installed Instrument Base, As of December 2015
Table 26 : Global Market For Instruments Used In Dna Sequencing and Rna-Sequencing, Through 2020
Table 27 : Requirements For Rna-Seq On Sequencing Platforms
Table 28 : Notable Liquid Handling Platforms For Rna-Seq Automation
Table 29 : Rna Sample and Library Preparation Platforms
Table 30 : Leading Products Preserving Rna Expression Profile
Table 31 : Leading Commercial Extraction Or Purification Kits
Table 32 : Rna Quantification Instrument
Table 33 : Rna Integrity Measuring Instrument
Table 34 : Rrna Deletion Kits
Table 35 : Mrna Enrichment Kits
Table 36 : Rna-Seq Kits For Illumina Platform
Table 37 : Thermo Fisher Rna-Seq Products For Ion Torrent
Table 38 : Thermo Fisher's Rna-Seq Library Prep Kits For Solid
Table 39 : Rna-Seq Library Prep Kits From 454
Table 40 : Pacbio's Rna-Seq Reagents Products
Table 41 : Rna-Seq Products From New England Biolabs
Table 42 : Rna-Seq Kits From Kapa Biosystems
Table 43 : Rna-Seq Products From Clontech
Table 44 : Rna-Seq Reagents From Nimblegen
Table 45 : Average Consumable Cost of Running Sequencing Machines
Table 46 : Global Market For Dna-Seq and Rna-Seq Consumables, Through 2020
Table 47 : Cloud Computing Providers For Genomics/Rna-Seq
Table 48 : Stand-Alone Rna-Seq Data Analysis Tools
Table 49 : Basespace Notable Rna-Seq Apps
Table 50 : Global Market For Rna-Seq Data Analysis, Through 2020
Table 51 : Illumina Certified Service Providers (Cspro) North America, As of November 2015
Table 52 : Illumina Certified Service Providers (Cspro) Europe, As of November 2015
Table 53 : Illumina Certified Service Providers (Cspro) Asia-Pacific, As of November 2015
Table 54 : Ion Torrent Certified Service Providers, As of November 2015
Table 55 : Solid Sequencing Service Providers, As of November 2015
Table 56 : Roche Sequencing Efforts
Table 57 : Nimblegen Certified Service Providers
Table 58 : Pacbio Certified Service Providers, As of November 2015
Table 59 : Additional Service Providers On Pacbio Platforms, As of November 2015
Table 60 : Agilent Certified Service Providers, As of November 2015
Table 61 : Non-Certified Rna-Seq Providers, As of November 2015
Table 62 : Non-Certified, Non-Profit Sequencing Service Providers, As of November 2015
Table 63 : Non-Certified, Commercial Sequencing Service Providers, As of November 2015
Table 64 : Sequencing Service Providers Certified By Multiple Programs, As of November 2015
Table 65 : Global Market For Rna-Seq Research Services, Through 2020

List of Figures
Summary Figure : Global Rna-Seq Market Trends By Segment, 2014-2020
Figure 1 : Cost of Sequencing One Raw Megabase of Dna
Figure 2 : Cost of Sequencing One Human Genome
Figure 3 : Generic Rna-Seq Experiment Workflow
Figure 4 : Rna-Seq Experiments For Transcriptomics
Figure 5 : Solid Rna-Seq Workflow
Figure 6 : 454's Dna Sequencer Mechanism
Figure 7 : Next-Generation Sequencing Data Analysis
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