Renal Diseases Drug Development Pipeline Review, 2018
Table of Contents
1 Table of Contents 4
1.1 List of Tables 5
1.2 List of Figures 7
2 Introduction 9
2.1 Renal Diseases Report Coverage 9
2.2 Chronic Kidney Disease (Chronic Renal Failure) - Overview 9
2.3 Kidney Fibrosis - Overview 9
2.4 Polycystic Kidney Disease - Overview 9
2.5 End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) - Overview 9
3 Therapeutics Development 10
3.1 Chronic Kidney Disease (Chronic Renal Failure) 10
3.2 Kidney Fibrosis 19
3.3 Polycystic Kidney Disease 25
3.4 End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 30
4 Therapeutics Assessment 33
4.1 Chronic Kidney Disease (Chronic Renal Failure) 33
4.2 Kidney Fibrosis 40
4.3 Polycystic Kidney Disease 48
4.4 End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 56
5 Companies Involved in Therapeutics Development 61
5.1 Chronic Kidney Disease (Chronic Renal Failure) 61
5.2 Kidney Fibrosis 80
5.3 Polycystic Kidney Disease 93
5.4 End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 99
6 Dormant Projects 102
6.1 Chronic Kidney Disease (Chronic Renal Failure) 102
6.2 Kidney Fibrosis 106
6.3 Polycystic Kidney Disease 107
6.4 End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 109
7 Discontinued Products 110
7.1 Chronic Kidney Disease (Chronic Renal Failure) 110
7.2 Kidney Fibrosis 111
7.3 Polycystic Kidney Disease 111
7.4 End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 111
8 Product Development Milestones 112
8.1 Chronic Kidney Disease (Chronic Renal Failure) 112
8.2 Kidney Fibrosis 127
8.3 Polycystic Kidney Disease 139
9 Appendix 153
9.1 Methodology 153
9.2 Coverage 153
9.3 Secondary Research 153
9.4 Primary Research 153
9.5 Expert Panel Validation 153
9.6 Contact Us 153
9.7 Disclaimer 154
List of Tables
Table 1: Number of Products under Development for Chronic Kidney Disease (Chronic Renal Failure) 10
Table 2: Number of Products under Development by Companies, Chronic Kidney Disease (Chronic Renal Failure) 12
Table 3: Number of Products under Development by Universities/Institutes, Chronic Kidney Disease (Chronic Renal Failure) 14
Table 4: Products under Development by Companies, Chronic Kidney Disease (Chronic Renal Failure) 15
Table 5: Products under Development by Universities/Institutes, Chronic Kidney Disease (Chronic Renal Failure) 18
Table 6: Number of Products under Development for Kidney Fibrosis 19
Table 7: Number of Products under Development by Companies, Kidney Fibrosis 21
Table 8: Number of Products under Development by Universities/Institutes, Kidney Fibrosis 22
Table 9: Products under Development by Companies, Kidney Fibrosis 23
Table 10: Products under Development by Universities/Institutes, Kidney Fibrosis 25
Table 11: Number of Products under Development for Polycystic Kidney Disease, Kidney Fibrosis 26
Table 12: Number of Products under Development by Companies, Kidney Fibrosis 27
Table 13: Number of Products under Development by Universities/Institutes, Kidney Fibrosis 27
Table 14: Products under Development by Companies, Kidney Fibrosis 28
Table 15: Products under Development by Universities/Institutes, Kidney Fibrosis 29
Table 16: Number of Products under Development for End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 30
Table 17: Number of Products under Development by Companies, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 31
Table 18: Products under Development by Companies, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 32
Table 19: Number of Products by Stage and Target, Chronic Kidney Disease (Chronic Renal Failure) 34
Table 20: Number of Products by Stage and Mechanism of Action, Chronic Kidney Disease (Chronic Renal Failure) 36
Table 21: Number of Products by Stage and Route of Administration, Chronic Kidney Disease (Chronic Renal Failure) 38
Table 22: Number of Products by Stage and Molecule Type, Chronic Kidney Disease (Chronic Renal Failure) 40
Table 23: Number of Products by Stage and Target, Kidney Fibrosis 42
Table 24: Number of Products by Stage and Mechanism of Action, Kidney Fibrosis 45
Table 25: Number of Products by Stage and Route of Administration, Kidney Fibrosis 46
Table 26: Number of Products by Stage and Molecule Type, Kidney Fibrosis 48
Table 27: Number of Products by Stage and Target, Polycystic Kidney Disease 50
Table 28: Number of Products by Stage and Mechanism of Action, Polycystic Kidney Disease 52
Table 29: Number of Products by Stage and Route of Administration, Polycystic Kidney Disease 54
Table 30: Number of Products by Stage and Molecule Type, Polycystic Kidney Disease 55
Table 31: Number of Products by Stage and Target, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 57
Table 32: Number of Products by Stage and Mechanism of Action, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 58
Table 33: Number of Products by Stage and Route of Administration, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 58
Table 34: Number of Products by Stage and Molecule Type, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 60
Table 35: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Allena Pharmaceuticals Inc 61
Table 36: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Angion Biomedica Corp 61
Table 37: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by apceth Biopharma GmbH 62
Table 38: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Arch Biopartners Inc 62
Table 39: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Astellas Pharma Inc 63
Table 40: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by AstraZeneca Plc 64
Table 41: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Bayer AG 64
Table 42: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Boehringer Ingelheim GmbH 65
Table 43: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Boryung Pharmaceutical Co Ltd 65
Table 44: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Cellmid Ltd 66
Table 45: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Corvidia Therapeutics Inc 66
Table 46: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by DiaMedica Therapeutics Inc 67
Table 47: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Dimerix Bioscience Pty Ltd 67
Table 48: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by DURECT Corp 68
Table 49: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Evotec AG 69
Table 50: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by GNI Group Ltd 69
Table 51: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by KBP BioSciences Co Ltd 70
Table 52: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Klotho Therapeutics Inc 70
Table 53: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Nash Pharmaceuticals Inc 71
Table 54: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Novartis AG 71
Table 55: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by OPKO Health Inc 72
Table 56: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Opsidio LLC 72
List of Figures
Figure 1: Number of Products under Development for Chronic Kidney Disease (Chronic Renal Failure) 10
Figure 2: Number of Products under Development by Companies, Chronic Kidney Disease (Chronic Renal Failure) 11
Figure 3: Number of Products under Development by Universities/Institutes, Chronic Kidney Disease (Chronic Renal Failure) 14
Figure 4: Number of Products under Development for Kidney Fibrosis 19
Figure 5: Number of Products under Development by Companies, Kidney Fibrosis 20
Figure 6: Number of Products under Development for Polycystic Kidney Disease, Kidney Fibrosis 25
Figure 7: Number of Products under Development by Companies, Kidney Fibrosis 26
Figure 8: Number of Products under Development for End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 30
Figure 9: Number of Products under Development by Companies, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 31
Figure 10: Number of Products by Top 10 Targets, Chronic Kidney Disease (Chronic Renal Failure) 33
Figure 11: Number of Products by Stage and Top 10 Targets, Chronic Kidney Disease (Chronic Renal Failure) 33
Figure 12: Number of Products by Top 10 Mechanism of Actions, Chronic Kidney Disease (Chronic Renal Failure) 35
Figure 13: Number of Products by Stage and Top 10 Mechanism of Actions, Chronic Kidney Disease (Chronic Renal Failure) 35
Figure 14: Number of Products by Routes of Administration, Chronic Kidney Disease (Chronic Renal Failure) 37
Figure 15: Number of Products by Stage and Routes of Administration, Chronic Kidney Disease (Chronic Renal Failure) 38
Figure 16: Number of Products by Top 10 Molecule Types, Chronic Kidney Disease (Chronic Renal Failure) 39
Figure 17: Number of Products by Stage and Top 10 Molecule Types, Chronic Kidney Disease (Chronic Renal Failure) 39
Figure 18: Number of Products by Top 10 Targets, Kidney Fibrosis 40
Figure 19: Number of Products by Stage and Top 10 Targets, Kidney Fibrosis 41
Figure 20: Number of Products by Top 10 Mechanism of Actions, Kidney Fibrosis 43
Figure 21: Number of Products by Stage and Top 10 Mechanism of Actions, Kidney Fibrosis 44
Figure 22: Number of Products by Stage and Routes of Administration, Kidney Fibrosis 46
Figure 23: Number of Products by Top 10 Molecule Types, Kidney Fibrosis 47
Figure 24: Number of Products by Stage and Top 10 Molecule Types, Kidney Fibrosis 47
Figure 25: Number of Products by Top 10 Targets, Polycystic Kidney Disease 48
Figure 26: Number of Products by Stage and Top 10 Targets, Polycystic Kidney Disease 49
Figure 27: Number of Products by Top 10 Mechanism of Actions, Polycystic Kidney Disease 51
Figure 28: Number of Products by Stage and Top 10 Mechanism of Actions, Polycystic Kidney Disease 51
Figure 29: Number of Products by Routes of Administration, Polycystic Kidney Disease 53
Figure 30: Number of Products by Stage and Routes of Administration, Polycystic Kidney Disease 53
Figure 31: Number of Products by Molecule Types, Polycystic Kidney Disease 54
Figure 32: Number of Products by Stage and Molecule Types, Polycystic Kidney Disease 55
Figure 33: Number of Products by Targets, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 56
Figure 34: Number of Products by Stage and Targets, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 56
Figure 35: Number of Products by Mechanism of Actions, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 57
Figure 36: Number of Products by Stage and Mechanism of Actions, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 58
Figure 37: Number of Products by Molecule Types, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 59
Figure 38: Number of Products by Stage and Molecule Types, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD) 59
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