Protein Analysis: Subfocus on Oncoproteomics

Publisher Name :
Date: 05-Sep-2018
No. of pages: 231

Report Scope:

The protein analysis market has significant potential bolstered by the rising demand from drug discovery and personalized medicine. The capabilities and possibilities of protein analysis market growth increase with growing new technologies and technological advancement in the market. Emerging economies such as China, Japan and South Korea are considered to be lucrative regions that are creating ample opportunities and scope for the protein analysis market. This market is expected to obtain investments and funding from government and private ventures, research institutes and universities to explore its potential. Growing clinical trials, drug discovery and clinical diagnostic and research through the protein analysis market will further boost this market in the near future. Sedentary lifestyles, unhealthy eating habits and upsurge in infectious viral and bacterial diseases are also creating opportunities for the protein analysis market. The global rise in infectious and noninfectious diseases, growing population, technological advancements and innovation are some other factors creating considerable demand within the protein analysis market.

The scope of this study covers the current market for drug discovery, clinical diagnostic and research into personalized medicine and so forth. The report also includes regulatory aspects, current and developing technologies, market projections and market share. Patents, clinical trials, innovations and opportunities, as well as the latest trends are also analyzed and discussed. The report intends to explain the key trends of protein analysis technologies. It also discusses the market determinants that act as motivating and restraining factors and provides insights to stakeholders and potential entrants. The report will be a key decision-making tool for government organizations, researchers, private players, angel investors, potential entrants and so forth.

Report Includes:

- 56 data tables and 37 additional tables

- An overview of the global market for protein analysis and oncoproteomics within the biotechnology industry

- Analyses of global market trends with data from 2017, estimates for 2018, and projections of compound annual growth rates (CAGRs) through 2023

- Coverage of the current market for drug discovery, clinical diagnostic and research into personalized medicine and so forth

- Discussion of factors such as global rise in infectious and noninfectious diseases, growing population, technological advancements and innovation, which create considerable demand within the protein analysis market

- Relevant patents analysis, clinical trials, innovations and opportunities

- Evaluation of key trends, present and future market strategies, technological advancements, and regulatory updates that have a major say in the protein analysis market

- Company profiles of the leading industry players, including Bio-Rad Laboratories Inc., Danaher Corp., GE Healthcare, GlaxoSmithKline PLC, GD Biosciences and Pfizer

Summary

The global protein analysis market has been achieving significant growth rate and the market is expected to grow with a compound annual growth rate (CAGR) REDACTED during the forecasted period of 2018 through 2023. The market size in 2017 was REDACTED, and this is estimated to exceed REDACTED by 2023. Protein analysis is a term used for analysis of the entire protein complement of a cell oran organism under given set of conditions. It has been used widely in various applications such as drug discovery and clinical diagnostics. Rising demand and U.S. Food and Drug Administration (FDA) approvals of personalized medicines due to their numerous benefits have been two of the major factors driving the

market growth. The proportion of FDA approval of personalized drugs increased from REDACTED in 2005 to REDACTED in 2016. As protein analysis is widely used for personalized medicines, it enables the market to grow significantly. Additionally, a rising aging population and an increase in lifestyle diseases has been motivating the market. According to theWorld Health Organization, cardiovascular diseases (CVDs) have been estimated as one of the major causes of mortality, and they account for more than 17.3 million deaths per year. It is further estimated that the fatalities due to CVDs are expected to reach 23.6 million by 2030.

These lifestyle diseases are growing at a significant rate, and protein analysis can be act as a bridge for drug discovery, customized medicines, biomarkers and research programs. Further, the diabetic population was recorded as 415 million in 2015, and it is projected that this will reach 642 million by 2040. This prevalence of lifestyle-related disorders reflects the need for protein analysis as a bridge for the drug discovery, customized medicines and biomarkers, thus promoting the market. Healthcare research and development (R&D) spending plays a significant role in the growth of the protein analysis market. As transformative research is responsible for development of new biomarkers and nextgeneration diagnostics and therapeutics, healthcare expenditure is a crucial element for the market.

Healthcare spending per capita in the U.S. was recorded as REDACTED in 2016, while healthcare spending per person in Switzerland was REDACTED, followed by Germany with REDACTED and the Netherlands with REDACTED.

Globally, national governments have been revising their healthcare expenditure taking into account increasing R&D. As a result, overall increase in the healthcare expenditure globally would drive the market, as research institutes will be able to obtain increased funding by governments for drug discovery. Strict regulatory approvals of protein analysis instruments have been one of the major restraints of the protein analysis market. These products require regulatory approval by the FDA and other regulatory bodies as they govern a broad range of activities such as quality management, design and development, labeling, manufacturing and so forth. Additionally, there are various regulations for

manufacturers and their customers, along with regulations in the areas of health and safety, packaging, product content and trade restrictions.

Manufacturers are required to follow complex foreign and U.S. laws and regulations, such as the U.S. Foreign Corrupt Practices Act, the U.K. Bribery Act and other local laws, violations of which can result in penalties and restrictions on the conduct of business. Additionally, high costs of these instruments affect their adoption in the industry. For instance, the Xevo TQ MS with Acquity HPLC (UHPLC) system offered by Waters Corp. costs around REDACTED, while Applied Biosystems' Sciex API 4000 LC-MS/MS system is available at a cost of around REDACTED. Both of these factors have a negative effect on the growth of protein analysis market. However, technological advancements in mass spectrometry/liquid chromatography (MS/LC) instrumentation, protein separation and emerging markets in developing economies such as China, Japan and South Korea are expected to drive the market growth in the upcoming years.

Protein Analysis: Subfocus on Oncoproteomics

Table of Contents

Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing This Study
Intended Audience
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports

Chapter 2 Summary and Highlights

Chapter 3 Market and Technology Background
Driving Forces
Ongoing Research in Personalized Medicine
Aging Population and Increase in Lifestyle-Related Diseases
Rising Healthcare and R&D Expenditures
Restraints
Tough Regulatory Approvals
High Cost of Protein Analysis Instruments and Equipment
Opportunities
Technological Advancements
Emerging Markets
Protein Analysis
Technology Platforms
Biochip-based Protein Analysis Technologies
Onco-Protein Analysis

Chapter 4 Market Breakdown by End Use
Drug Discovery and R&D
Clinical Diagnosis
Others

Chapter 5 Market Breakdown by Instrumentation/Reagent Technology
Mass Spectrometry
Mass Spectrometry Imaging
Biochips
Protein Microarrays
Chromatography
Microscale Thermophoresis
NMR Spectroscopy
Electrophoresis
Capillary Electrophoresis
Others
X-Ray Crystallography Instrumentation
Protein Fractionation

Chapter 6 Market Breakdown by Type of Disease/Diagnostic
Cancer
Bladder Cancer
Breast Cancer
Colorectal Cancer
Gastric Cancer
Kidney Cancer
Lung Cancer
Lymphoma Cancer
Ovarian Cancer
Pancreatic Cancer
Prostate Cancer
Thyroid Cancer
Infectious Diseases
Diabetes
Neurological Disorders
Alzheimer's Disease
Schizophrenia
Cardiovascular Diseases
Autoimmune Diseases
HLA Typing
Prenatal Testing

Chapter 7 Market Breakdown by Type of Service and Industry Application
Quantitative Services
Laboratory Services
Simple Protein Identification
Multidimensional LC-MS
Protein Mass Spectrometry
2D Difference Gel Electrophoresis
Protein Profiling
Protein-Identification and Separation Services
Protein Sequencing Services
Protein-Imaging Services
Breakdown by Application Industry
Biotechnology Industry
Pharmaceutical Industry
Other (Research Institutes and Academics)
Market Breakdown by Service
Market Breakdown by Industry
Biotechnology Industry Applications by Region
Pharmaceutical Industry Applications by Region
Other Industry Applications by Region

Chapter 8 Market Breakdown by Region
North America
U.S.
Canada
Asia-Pacific
China
Japan
South Korea
India
Rest of Asia-Pacific
Europe
U.K.
France
Germany
Rest of Europe
Rest of the World
Middle East
Africa
Latin America

Chapter 9 Patent Review/New Developments
Competitive Landscape
Top Companies
Key Strategies

Chapter 10 Company Profiles
ABCODIA
ADVANCE PROTEOME THERAPEUTICS CORP.
AGILENT TECHNOLOGIES INC.
ANATRACE
APPLIED MICROARRAYS INC.
ARRAYIT CORP.
ASTUTE MEDICAL INC.
AVACTA
AYOXXA BIOSYSTEMS GMBH
BIODESIX INC.
BIOGNOSYS AG
BIOMERIEUX
BIOPROXIMITY
BIO-RAD LABORATORIES INC.
BIO-TECHNE INC.
BRUCKER
CAMBRIDGE PROTEIN ARRAYS LTD.
CAPRION BIOSCIENCES INC.
CDI LABORATORIES INC.
CREATIVE PROTEOMICS INC.
CRELUX GMBH
CRYSTALGENOMICS
DANAHER CORP.
EPICYPHER
EVOTEC
FLUIDIGM
GE HEALTHCARE
GLAXOSMITHKLINE PLC
GD BIOSCIENCES
GL SCIENCES
HEALTHTELL
HYBRIGENICS SA
IMMUNOVIA
IMTAKT CORP.
INTEGRATED DIAGNOSTICS INC.
INDI MOLECULAR
LABCYTE INC.
LUMINEX CORP.
MERCK KGAA
MOSAIQUES DIAGNOSTICS AND THERAPEUTICS AG
MRM PROTEOMICS
MS BIOWORKS LLC
MYCARTIS
MYRIAD GENETICS INC.
NANTOMICS
NEWOMICS
NIRMIDAS BIOTECH
OPKO HEALTH INC.
PERKINELMER
PFIZER
PHYLOGICA
PRESSURE BIOSCIENCES INC.
PROMETIC LIFE SCIENCE INC.
PROTAGEN AG
PROTEA BIOSCIENCES INC.
PROTEOCYTE AI
PROTEOGENIX
PROTEOME SCIENCES
PROTEOMICS INTERNATIONAL
PROTEOVISTA
QIAGEN NV
QUANSYS BIOSCIENCES
QUANTERIX
QUEST DIAGNOSTICS
RAYBIOTEC
REPLIGEN CORP.
RETROGENIX
SAMDI TECH INC.
SERA PROGNOSTICS
SHIMADZU CORP.
SHOWA DANKO KK
SIGMA-ALDRICH CORP.
SISCAPA ASSAY TECHNOLOGIES
SOMALOGIC INC.
SPHERE FLUIDICS
SPOTON CLINICAL DIAGNOSTICS
SQI DIAGNOSTICS
THERMOFISHER SCIENTIFIC INC.
THORNE DIAGNOSTICS
VERMILLION
WATERS CORP.
XENCOR

List of Tables

Summary Table : Global Market for Protein Analysis, by Region, Through 2023
Table 1 : Population Distribution in Major Countries, by Age, 2017
Table 2 : Prices of Laboratory Protein Analysis Instruments
Table 3 : Laboratories Across India Involved in Proteome-Level Research Investigations
Table 4 : Protein Biochip Systems
Table 5 : Biochip-based Protein Analysis Technologies
Table 6 : Planar-based versus Bead-based Arrays
Table 7 : Advantages of Multiplexing for Diagnostics
Table 8 : Proteomic Applications in Drug Discovery and Development
Table 9 : Advantages and Drawbacks of the Proteomic Approaches Available to Onco-Protein Analysis
Table 10 : Emerging Approaches for Onco-protein Analysis
Table 11 : Comparison of Protein Biomarkers and Current Tumor Markers
Table 12 : Global Market for Protein Analysis, by End Use, Through 2023
Table 13 : Global Market for the Application of Protein Analysis in Drug Discovery and Research, by Region, Through 2023
Table 14 : Global Market for the Application of Protein Analysis in Clinical Diagnosis, by Region, Through 2023
Table 15 : Global Market for the Application of Protein Analysis in Other End Uses, by Region, Through 2023
Table 16 : Comparison of Performance Characteristics of Commonly Used Mass Spectrometers for Protein Analysis
Table 17 : Mass Spectrometers Available in the Market
Table 18 : Protein Microarrays Available in the Market
Table 19 : Chromatography Systems Available in the Market
Table 20 : Microscale Thermophoresis Systems Available in the Market
Table 21 : Capillary Electrophoresis Products Available in the Market
Table 22 : Gel-Electrophoresis Instrumentation Available in the Market
Table 23 : Products for X-ray Crystallography Available in the Market
Table 24 : Protein Fractionation Accessories Available in the Market
Table 25 : Global Market for Protein Analysis, by Instrumentation/Reagent Technology, Through 2023
Table 26 : Global Market for Protein Analysis, by Mass Spectrometry Segment, Through 2023
Table 27 : Global Market for Protein Analysis, by Type of Mass Spectrometry Instrument, Through 2023
Table 28 : Global Market for Protein Analysis, by Type of Mass Spectrometry Consumable, Through 2023
Table 29 : Global Market for the Application of Mass Spectrometry in Protein Analysis, by Region, Through 2023
Table 30 : Global Market for Protein Analysis, by Type of Biochip, Through 2023
Table 31 : Global Market for Protein Analysis, by Type of Microarray, Through 2023
Table 32 : Global Market for the Application of Biochips in Protein Analysis, by Region, Through 2023
Table 33 : Global Market for the Application of Chromatography in Protein Analysis, by Region, Through 2023
Table 34 : Global Market for the Application of Microscale Thermophoresis in Protein Analysis, by Region, Through 2023
Table 35 : Global Market for the Application of NMR Spectroscopy in Protein Analysis, by Region, Through 2023
Table 36 : Global Market for the Application of Electrophoresis in Protein Analysis, by Region, Through 2023
Table 37 : Global Market for Other Instrumentation and Reagent Technologies, by Region, Through 2023
Table 38 : Estimated U.S. Incidence and Deaths for Selected Cancers, 2013 vs 2018
Table 39 : Protein-based Urine Tests for Bladder-Cancer Detection
Table 40 : Estimated Number of Annual Breast Cancer Treatment Decisions in the U.S. by Cancer Classification
Table 41 : Breast Cancer MDx Technology Platforms
Table 42 : Colorectal Cancer Biomarkers and Their Related Information
Table 43 : Quantitative Protein Analysis Studies in Lung Cancer, 2014-2016
Table 44 : Ovarian Cancer-specific Overexpressed Markers
Table 45 : Quantitative Protein Analysis Methods for Identification of Biomarkers in Neurological Disorders
Table 46 : Alzheimer's Disease Diagnostic Approaches
Table 47 : Current Markers Used for Routine Prenatal Screening and Their Applications
Table 48 : Global Market for Protein Analysis in Clinical Diagnosis, by Disease/Application, Through 2023
Table 49 : Global Market for Protein Analysis in Disease Diagnosis, by Cancer Type, Through 2023
Table 50 : Key Protein Analysis Services
Table 51 : Services Offered by Various Companies and Their Prices
Table 52 : Companies Offering Transmission Electron Microscopy Products
Table 53 : List of Products and Their Prices
Table 54 : Global Market for Protein Analysis, by Service, Through 2023
Table 55 : Global Market for Protein Analysis, by Application Industry, Through 2023
Table 56 : Global Market for the Application of Protein Analysis in the Biotechnology Industry, by Region, Through 2023
Table 57 : Global Market for the Application of Protein Analysis in the Pharmaceutical Industry, by Region, Through 2023
Table 58 : Global Market for the Application of Protein Analysis in Other Industries, by Region, Through 2023
Table 59 : North American Market for Protein Analysis, by Country, Through 2023
Table 60 : North American Market for Protein Analysis, by End Use, Through 2023
Table 61 : North American Market for Protein Analysis, by Instrumentation/Reagent Technology, Through 2023
Table 62 : North American Market for Protein Analysis, by Mass Spectrometry Segment, Through 2023
Table 63 : North American Market for Protein Analysis, by Type of Biochip, Through 2023
Table 64 : North American Market for Protein Analysis, by Type of Service, Through 2023
Table 65 : North American Market for Protein Analysis, by Application Industry, Through 2023
Table 66 : Asia-Pacific Market for Protein Analysis, by Country/Region, Through 2023
Table 67 : Asia-Pacific Market for Protein Analysis, by End Use, Through 2023
Table 68 : Asia-Pacific Market for Protein Analysis, by Instrumentation/Reagent Technology, Through 2023
Table 69 : Asia-Pacific Market for Protein Analysis, by Mass Spectrometry Segment, Through 2023
Table 70 : Asia-Pacific Market for Protein Analysis, by Type of Biochip, Through 2023
Table 71 : Asia-Pacific Market for Protein Analysis, by Type of Service, Through 2023
Table 72 : Asia-Pacific Market for Protein Analysis, by Application Industry, Through 2023
Table 73 : Approximate Prevalence of Diabetes in China, 2015-2017
Table 74 : European Market for Protein Analysis, by Country, Through 2023
Table 75 : European Market for Protein Analysis, by End Use, Through 2023
Table 76 : European Market for Protein Analysis, by Instrumentation/Reagent Technology, Through 2023
Table 77 : European Market for Protein Analysis, by Mass Spectrometry Segment, Through 2023
Table 78 : European Market for Protein Analysis, by Type of Biochip, Through 2023
Table 79 : European Market for Protein Analysis, by Type of Service, Through 2023
Table 80 : European Market for Protein Analysis, by Application Industry, Through 2023
Table 81 : RoW Market for Protein Analysis, by End Use, Through 2023
Table 82 : RoW Market for Protein Analysis, by Instrumentation/Reagent Technology, Through 2023
Table 83 : RoW Market for Protein Analysis, by Mass Spectrometry Segment, Through 2023
Table 84 : RoW Market for Protein Analysis, by Type of Biochip, Through 2023
Table 85 : RoW Market for Protein Analysis, by Type of Service, Through 2023
Table 86 : RoW Market for Protein Analysis, by Application Industry, Through 2023
Table 87 : Number of Patents on Protein Analysis Equipment and Reagents in Different Countries, 2016-2018
Table 88 : Number of Patents, by Instrument Category, 2016-2018
Table 89 : Number of Patents, by Key Company/Institution, 2016-2018
Table 90 : Key Activities of Major Companies, 2015-2017
Table 91 : Market Activity, by Company, 2015-2017
Table 92 : Company Activities, 2015-2017

List of Figures

Summary Figure : Global Market for Protein Analysis, by Region, 2017-2023
Figure 1 : Total Healthcare Expenditures per Capita, by Select Country, 2016
Figure 2 : Stem Cell Research Investments in the U.S., 2013-2017
Figure 3 : Stages of Protein Analysis
Figure 4 : Protein Analysis Techniques
Figure 5 : Aspects of Protein Function
Figure 6 : Advantages of MALDI-TOF Instruments
Figure 7 : Proteogenomics Workflow
Figure 8 : Flow Chart of Protein Identification, by Mass-Spectrometry-based Protein Analysis
Figure 9 : Focus of the Activities of the OncoProtein Analysis Laboratory
Figure 10 : Steps Involved in the Drug-Discovery Process
Figure 11 : Disadvantages of Protein Microarrays
Figure 12 : Advantages of Planar Protein Arrays
Figure 13 : Disadvantages of Planar Protein Arrays
Figure 14 : Description of the Bead Protein Array Method
Figure 15 : Chromatography Protein Analysis Workflow
Figure 16 : Application of Microscale Thermophoresis
Figure 17 : Advantages of NMR Spectroscopy
Figure 18 : Disadvantages of NMR Spectroscopy
Figure 19 : Advantages of Capillary Electrophoresis
Figure 20 : Advantages of Gel Electrophoresis
Figure 21 : Two Ways to Diagnosis Bladder Cancer
Figure 22 : Protein Analysis and Infectious Diseases
Figure 23 : Role of Protein Analysis in the Search for Biomarkers and Mechanisms of Acquired Cardiovascular Diseases
Figure 24 : Protein-Sequencing Process
Figure 25 : Medicine in Development, by Type of Disease, 2017
Figure 26 : Pharma Member Company R&D Expenditures, 1995-2016
Figure 27 : Gross Domestic Spending on Healthcare R&D in North American Countries, 2016
Figure 28 : Personalized Medicines Top 30% of FDA Approvals for First Time in 2017
Figure 29 : Japanese Pharmaceutical R&D Expenditures, 1995-2015
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