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Presbyopia - Pipeline Insight, 2021

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Date: 12-Oct-2021
No. of pages: 60
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DelveInsight's, "Presbyopia - Pipeline Insight, 2021," report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Presbyopia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

- Global coverage

Presbyopia Understanding

Presbyopia: Overview

Presbyopia is the gradual loss of eyes' ability to focus on nearby objects. It's a natural part of aging. Common symptoms of presbyopia are eyestrain or headaches after reading or doing close work, difficulty reading small print, fatigue from doing close work, overall problems seeing and focusing on objects that are close, or squinting. Presbyopia is diagnosed by a basic eye exam, which includes a refraction assessment and an eye health exam. The goal of treatment is to compensate for the inability of the eyes to focus on nearby objects. Treatment options include wearing corrective eyeglasses (spectacle lenses) or contact lenses, undergoing refractive surgery, or getting lens implants for presbyopia.

"Presbyopia - Pipeline Insight, 2021" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Presbyopia pipeline landscape is provided which includes the disease overview and Presbyopia treatment guidelines. The assessment part of the report embraces, in depth Presbyopia commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Presbyopia collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

- The companies and academics are working to assess challenges and seek opportunities that could influence Presbyopia R&D. The therapies under development are focused on novel approaches to treat/improve Presbyopia.

Presbyopia Emerging Drugs Chapters

This segment of the Presbyopia report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Presbyopia Emerging Drugs

- AGN-190584: AbbVie

AGN-190584 is an investigational, novel optimized formulation of pilocarpine specifically designed for the treatment of presbyopia as a topical, once-daily drop delivered by a proprietary vehicle. The primary mechanism of action is through pupil constriction to enhance depth of focus and improve near and intermediate vision while maintaining pupillary response to different lighting conditions - an effect known as dynamic pupil modulation. The drug is in Preregistration for the treatment of Presbyopia.

- BRIMOCHOL: Visus Therapeutics

BRIMOCHOL is a proprietary pupil-modulating eye drop that combines two well-studied, FDA-approved pharmaceuticals: carbachol (a cholinergic agent) and brimonidine tartrate (an alpha-2 agonist). Together, they produce a "pinhole effect," which reduces the size of the pupil so that only centrally focused light rays are able to enter the eye, thereby sharpening distant and near images while minimizing side effects. The drug is in Phase II clinical studies for the treatment of Presbyopia.

Further product details are provided in the report……

Presbyopia: Therapeutic Assessment

This segment of the report provides insights about the different Presbyopia drugs segregated based on following parameters that define the scope of the report, such as:

- Major Players in Presbyopia

There are approx. 10+ key companies which are developing the therapies for Presbyopia. The companies which have their Presbyopia drug candidates in the most advanced stage, i.e. Preregistration include, AbbVie.

- Phases

DelveInsight's report covers around 10+ products under different phases of clinical development like

- Late stage products (Phase III)

- Mid-stage products (Phase II)

- Early-stage product (Phase I) along with the details of

- Pre-clinical and Discovery stage candidates

- Discontinued & Inactive candidates

- Route of Administration

Presbyopia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

- Oral

- Parenteral

- Intravitreal

- Subretinal

- Topical

- Molecule Type

Products have been categorized under various Molecule types such as

- Monoclonal Antibody

- Peptides

- Polymer

- Small molecule

- Gene therapy

- Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Presbyopia: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Presbyopia therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Presbyopia drugs.

Presbyopia Report Insights

- Presbyopia Pipeline Analysis

- Therapeutic Assessment

- Unmet Needs

- Impact of Drugs

Presbyopia Report Assessment

- Pipeline Product Profiles

- Therapeutic Assessment

- Pipeline Assessment

- Inactive drugs assessment

- Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

- How many companies are developing Presbyopia drugs?

- How many Presbyopia drugs are developed by each company?

- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Presbyopia?

- What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Presbyopia therapeutics?

- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?

- What are the clinical studies going on for Presbyopia and their status?

- What are the key designations that have been granted to the emerging drugs?

Key Players

- AbbVie

- Orasis Pharmaceuticals

- Eyenovia

- Aclaris Therapeutics

- Ocuphire Pharma

- Visus Therapeutics

- Ocularis Pharma

- Cellix Bio

Key Products

- AGN-190584

- AGN-241622

- CSF-1

- ARVN-003

- Oxymetazoline

- Phentolamine/pilocarpine

- BRIMOCHOL

- Phentolamine

- CLX-OPH-561

Presbyopia - Pipeline Insight, 2021

Table of Contents

Introduction
Executive Summary
Presbyopia: Overview
* Causes
* Mechanism of Action
* Signs and Symptoms
* Diagnosis
* Disease Management
Pipeline Therapeutics
* Comparative Analysis
Therapeutic Assessment
* Assessment by Product Type
* Assessment by Stage and Product Type
* Assessment by Route of Administration
* Assessment by Stage and Route of Administration
* Assessment by Molecule Type
* Assessment by Stage and Molecule Type
Presbyopia - DelveInsight's Analytical Perspective
Late Stage Products (Phase III)
* Comparative Analysis
CSF-1: Orasis Pharmaceuticals
* Product Description
* Research and Development
* Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
* Comparative Analysis
BRIMOCHOL: Visus Therapeutics
* Product Description
* Research and Development
* Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I/II)
* Comparative Analysis
AGN-241622: AbbVie
* Product Description
* Research and Development
* Product Development Activities
Drug profiles in the detailed report…..
Preclinical/Discovery Stage Products
* Comparative Analysis
CLX-OPH-561: Cellix Bio
* Product Description
* Research and Development
* Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
* Comparative Analysis
Presbyopia Key Companies
Presbyopia Key Products
Presbyopia- Unmet Needs
Presbyopia- Market Drivers and Barriers
Presbyopia- Future Perspectives and Conclusion
Presbyopia Analyst Views
Appendix

List of Tables

Table 1 Total Products for Presbyopia
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

List of Figures

Figure 1 Total Products for Presbyopia
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products
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