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Pharmaceutical Chemicals to 2019

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Date: 26-Jun-2015
No. of pages: 497
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US demand to increase 6.1% annually through 2019

US demand for pharmaceutical chemicals is forecast to rise 6.1 percent annually to $54 billion in 2019. Merchant market sales primarily to generic drug companies will account for nearly one-third of this total. The remainder of demand will consist of the value of pharmaceutical chemicals produced captively or contracted for internal use by makers of proprietary drugs.

New therapies to drive captive & contract market

Although moderated by patent losses, the value of pharmaceutical chemicals obtained from captive and contract production systems will sustain favorable growth, expanding 5.3 percent annually to $36.7 billion in 2019. The introduction of new therapies with enhanced efficacy will underlie gains. For example, in 2014, a total of 41 new molecular entities were approved for marketing by the Food and Drug Administration. Among these approvals were several breakthrough therapies, including blinatumomab for acute lymphoblastic leukemia, ceritinib for late-stage non-small cell lung cancer, ledipasvir/sofosbuvir for chronic hepatitis C, nintedanib and pirfenidone for idiopathic pulmonary fibrosis, and nivolumab for metastatic melanoma. In addition to new molecular entities, growth prospects for proprietary pharmaceutical chemicals will benefit from a number of recent prescription to over-thecounter switches, which extended commercial protection on non-prescription versions of compounds such as esomeprazole magnesium and fluticasone proprionate.

Merchant market demand to grow nearly 8% per annum

Based on the impact of recent and forthcoming drug patent expirations and the expansion of the generic drug industry, merchant market demand for pharmaceutical chemicals will increase 7.8 percent per year to $17.3 billion in 2019. Gains will reflect the introduction and rapid market penetration of generic versions of several blockbuster drugs. Among the pharmaceutical chemicals projected to generate impressive growth in merchant sales due to patent expirations are aripiprazole for bipolar disorder; capecitabine for metastatic breast and colorectal cancer; celecoxib for arthritis; duloxitine HCl for depression, generalized anxiety, and chronic pain; eszopiclone for insomnia; glatiramer acetate for multiple sclerosis; oxycodone HCl for pain management; and raloxifene HCl for osteoporosis.

Company Profiles

Profiles 51 competitors in the US industry including BASF, Cambrex, FMC, Royal DSM, Johnson Matthey, Mallinckrodt, Lonza & Teva Pharmaceuticals

Additional Information

This comprehensive study analyzes the US market for pharmaceutical chemicals, focusing on therapeutically active medicinal substances that serve as ingredients of finished drug formulations. Pharmaceutical excipients, intermediates, and processing chemicals are not included in the analysis nor reflected in the demand and market share statistics appearing in the study. Historical data (2004, 2009, 2014) and forecasts for 2019 and 2024 are provided for active pharmaceutical chemicals by type -- including central nervous system, hormones and related, cardiovascular, anti-infective, nutritional, biological, respiratory, gastrointestinal, dermatological, genito-urinary, and other compounds.

Unless otherwise indicated, the statistics presented in the study for pharmaceutical chemicals represent demand stated in current US dollars. Demand includes sales of compounds on the open merchant market and the value of compounds obtained from captive and contract production systems. Pharmaceutical chemicals sold on the merchant market serve primarily as active ingredients of generic and other multiple supplier drugs and nutritional preparations. Most compounds obtained from captive and contract production systems are employed directly in the manufacture of patent-protected and other proprietary therapies. In addition to sources of supply, the study analyzes demand patterns and growth prospects involving applications in ethical and over-the-counter (OTC) products.

Pharmaceutical Chemicals to 2019

Table of Contents

Introduction XIV

I. Executive Summary 1

II. Market Environment 4
General 4
Macroeconomic Factors 4
Demographic Patterns 9
Healthcare Trends 12
Health Insurance Reforms 13
Medical Conditions 16
Acute Conditions 16
Chronic Conditions 17
National Health Expenditures 20
Spending Categories 21
Funding Sources 24
Medical Providers 27
Hospitals 28
Outpatient Facilities 29
Physicians 30
Skilled Nursing Homes 30
Patient Activity 31
Hospital Activity 32
Outpatient Activity 33
Surgical Procedures 33
Pharmaceutical Industry Overview 34
Regulation 35
Research & Development 37
Product Shipments 38
Therapeutic Groups 38
Distribution Classes 41
Commercial Status 43

III. Pharmaceutical Chemicals Overview 46
General 46
Historical Demand Patterns 47
US Trade 48
International Markets 49
Therapeutic Groups 51
Merchant Market Demand 54
Captive & Contract Production 56
Ethical Pharmaceutical Chemicals 58
Over-the-Counter Pharmaceutical Chemicals 59

IV. Central Nervous System Chemicals 61
General 61
Psychotherapeutic Agents 64
Antipsychotic Agents 66
Antidepressants 68
Anti-Anxiety Agents 70
OTC Sedatives 72
Neurological Agents 72
Anticonvulsants 74
Multiple Sclerosis Treatments 75
Alzheimer’s Disease Treatments 77
Parkinson’s Disease Treatments 82
Other Neurological Agents 86
Pain Control Agents 87
Narcotic Analgesics 89
Over-the-Counter Analgesics 95
Ethical Nonsteroidal Anti-Inflammatory Agents 97
Antimigraine Agents 101
Anesthetics 105
Hyaluronic Acid 110
Rheumatoid Arthritis Treatment Chemicals 111
Monoclonal Antibodies 113
Other Arthritis Treatments 116
Ophthalmic Agents 118
Anti-Angiogenic Agents 119
Glaucoma Treatments 122
Other Ophthalmic Agents 124
Other Central Nervous System Chemicals 128
CNS Stimulants 129
Muscle Relaxants 132
Smoking Cessation Compounds 134
Anti-Obesity Agents 137

V. Hormones & Related Chemicals 140
General 140
Anticancer Agents 143
Monoclonal Antibodies 145
Enzyme Inhibitors 150
Growth Factors 155
Immunomodulating Agents 157
Other Anticancer Agents 159
Selected Anticancer Agents in Development 164
Antidiabetic Agents 167
Insulins 169
DPP-4 Inhibitors 171
Biguanides 172
Thiazolidinediones 173
GLP-1 Agonists 174
Sulfonylureas 176
Other Antidiabetic Agents 177
Hormone Replacement Therapies 178
Thyroid Agents 180
Erythropoietins 181
Estrogens 183
Growth Hormones 185
Other Hormone & Related Replacement Therapies 186
Bisphosphonates & Related Agents 189
Hormonal Contraceptives 191
Combination Oral Contraceptives 192
Progestin-Only Pills 193
Other Hormonal Contraceptives 193
Other Hormones & Related Agents 194

VI. Cardiovascular Chemicals 197
General 197
Cholesterol Reducers 200
Antithrombolytic Agents 203
Patent Expirations 204
Marketed Products 205
Beta Blockers 207
Calcium Channel Blockers 209
Angiotensin II Receptor Antagonists 210
ACE Inhibitors 212
Diuretics 213
Other Cardiovascular Drugs 214
Alpha Adrenergic Agonists 215
Anti-Arrhythmics 215
Bradykinin B2 Receptor Antagonists 216
Cardiac Glycosides 217
Endothelin Receptor Antagonists 217
Vasodilators 218
All Other Cardiovascular Drugs 219

VII. Anti-Infective Chemicals 220
General 220
Antiviral Agents 222
Hepatitis Antiviral Agents 223
HIV Antiviral Agents 228
Other Antiviral Agents 233
Antibiotics 238
Penicillins 239
Macrolides 242
Cephalosporins 244
Quinolones 245
Other Antibiotics 247
Oral Antiseptics 254
Other Anti-Infective Agents 256
Antifungal Agents 257
Antimalarial Agents 260

VIII. Nutritional Chemicals 262
General 262
Herbal & Related Ingredients 264
Herbal & Botanical Extracts 265
Fish Oils 278
Marine & Related Extracts 281
Nutrients 285
Proteins 286
Fibers 290
Probiotics 295
Other Nutrients 296
Bulk Minerals 305
Electrolytes 306
Essential Minerals 307
Trace Minerals 310
Bulk Vitamins 311
Vitamin C 313
Vitamin A 315
B-Group Vitamins 317
Vitamin E 322
Other Vitamins 324

IX. Biological Chemicals 327
General 327
Vaccines 328
Attenuated Vaccines 329
Conjugate Vaccines 330
Inactivated Vaccines 331
Recombinant Vaccines 332
Toxoid Vaccines 333
Vaccines in Development 334
Blood Derivatives 335
Plasma Protein Therapies 336
Cellular Components 342
Other Blood-Related Chemicals 344

X. Respiratory Chemicals 346
General 346
Bronchodilators 348
Antihistamines 352
Inhaled Corticosteroids 354
Antitussives 357
Other Respiratory Chemicals 359
Decongestants 360
Expectorants & Mucolytics 360
Omalizumab 361
Leukotriene Receptor Antagonists (LRAs) 361
Selective Phosphodiesterase-4 Inhibitors 362
Ivacaftor 362
Nintedanib 363
Pirfenidone 363
Surfactants 364

XI. Gastrointestinal Chemicals 365
General 365
Proton Pump Inhibitors 367
Anti-Emetic Agents 369
Laxatives 371
Gastrointestinal Anti-Inflammatory Agents 374
OTC Antacids 376
Antidiarrheals 377
Other Gastrointestinal Agents 379

XII. Dermatological Chemicals 383
General 383
Antipsoriatic Agents 385
Dermatological Anti-Infective Agents 389
Antibacterial Compounds 390
Antifungal Compounds 391
Other Dermatological Anti-Infective Compounds 393
External Analgesics 393
Anti-Acne Agents 395
Other Dermatological Chemicals 397

XIII. Other Pharmaceutical Chemicals 400
General 400
Genito-Urinary Chemicals 401
Erectile Dysfunction (ED) Treatments 403
Benign Prostate Hyperplasia (BPH) Treatments 404
Overactive Bladder Treatments 404
All Other Pharmaceutical Chemicals 405
Antitransplant Rejection Agents 406
Chelating Agents 408

XIV. Industry Structure 409
General 409
Market Share 412
Competitive Strategies 417
Mergers & Acquisitions 418
Licensing & Related Agreements 421
Marketing & Distribution 424
Manufacturing 426
Company Profiles 428
Aceto Corporation 429
Ajinomoto Company Incorporated 430
Albemarle Corporation 432
Althea Technologies, see Ajinomoto
American Pacific Corporation 434
Aptuit LLC 435
Aurobindo Pharma Limited 437
BASF SE 439
Biocon Limited 441
Cambrex Corporation 444
Carbogen Amcis, see Dishman Pharmaceuticals and Chemicals
Cipla Limited 446
Daiichi Fine Chemical, see Kyowa Hakko Kirin Daiichi Sankyo Company Limited 447
Dishman Pharmaceuticals and Chemicals Limited 449
Dr. Reddy’s Laboratories Limited 451
DSM Sinochem Pharmaceuticals, see Royal DSM Epax, see FMC Fabbrica Italiana Sintetici SpA 453
FMC Corporation 455
FUJIFILM Holdings Corporation 457
Johnson & Johnson 459
Johnson Matthey plc 460
Kyowa Hakko Kirin Company Limited 462
Lonza Group Limited 464
Lupin Limited 465
Macfarlan Smith, see Johnson Matthey
Mallinckrodt plc 467
Noramco, see Johnson & Johnson Novartis AG 469
Novasep Holding SAS 471
Pfanstiehl Incorporated 472
PHF, see Fabbrica Italiana Sintetici Ranbaxy Laboratories, see Sun Pharmaceutical Industries Royal DSM NV 474
Shanghai SynTheAll Pharmaceutical, see WuXi PharmaTech Cayman SI Group Incorporated 477
Sigma-Aldrich Corporation 478
Sun Pharmaceutical Industries Limited 480
Teva Pharmaceutical Industries Limited 483
WuXi PharmaTech Cayman Incorporated 485
Additional Companies in the Pharmaceutical Chemicals Industry 487

List of Tables

Section I -- Executive Summary
Summary Table 3

Section II -- Market Environment
1 Macroeconomic Indicators 9
2 Resident Population by Age Group 12
3 Health Insurance Coverage of the US Population, 2004-2014 15
4 Acute Conditions by Type 17
5 Chronic Conditions by Type 20
6 National Health Expenditures by Spending Category 24
7 National Health Expenditures by Funding Source 27
8 Medical Providers 28
9 Patient Activity 32
10 Pharmaceutical Shipments by Therapeutic Group 40
11 Pharmaceutical Shipments by Distribution Status 43
12 Pharmaceutical Shipments by Commercial Status 45

Section III -- Pharmaceutical Chemicals Overview
1 Pharmaceutical Chemicals Demand, 2004-2014 47
2 US Trade in Pharmaceutical Chemicals 49
3 World Pharmaceutical Chemicals Merchant Demand 51
4 Pharmaceutical Chemicals Demand by Therapeutic Group 53
5 Pharmaceutical Chemicals: Merchant Market Demand by Therapeutic Group 56
6 Pharmaceutical Chemicals: Captive & Contract Production Output 57
7 Pharmaceutical Chemicals: Ethical Pharmaceuticals Demand 59
8 Pharmaceutical Chemicals: Over-the-Counter Pharmaceuticals Demand 60

Section IV -- Central Nervous System Chemicals
1 Central Nervous System (CNS) Chemicals Demand 63
2 Psychotherapeutic Chemicals Demand 66
3 Neurological Chemicals Demand 73
4 Pain Control Chemicals Demand 89
5 Rheumatoid Arthritis Treatment Chemicals Demand by Source of Supply 113
6 Ophthalmic Chemicals Demand 119
7 Other Central Nervous System Chemicals Demand 129

Section V -- Hormones & Related Chemicals
1 Hormones & Related Chemicals Demand 142
2 Anticancer Chemicals Demand 144
3 Antidiabetic Chemicals Demand 168
4 Hormone Replacement Chemicals Demand 179
5 Bisphosphonates & Related Chemicals Demand by Source of Supply 191
6 Hormonal Contraceptive Chemicals Demand by Source of Supply 192
7 Other Hormones & Related Chemicals Demand by Source of Supply 196

Section VI -- Cardiovascular Chemicals
1 Cardiovascular Chemicals Demand 199
2 Cholesterol-Reducing Chemicals Demand by Source of Supply 203
3 Antithrombolytic Chemicals Demand by Source of Supply 204
4 Beta Blocker Chemicals Demand by Source of Supply 208
5 Calcium Channel Blocker Chemicals Demand by Source of Supply 210
6 Angiotensin II Antagonist Chemicals Demand by Source of Supply 212
7 ACE Inhibitor Chemicals Demand by Source of Supply 213
8 Diuretic Chemicals Demand by Source of Supply 214
9 Other Cardiovascular Chemicals Demand by Source of Supply 215

Section VII -- Anti-Infective Chemicals
1 Anti-Infective Chemicals Demand 221
2 Antiviral Chemicals Demand 223
3 Antibiotic Chemicals Demand 239
4 Oral Antiseptics Chemicals Demand by Source of Supply 256
5 Other Anti-Infective Chemicals Demand 257

Section VIII -- Nutritional Chemicals
1 Nutritional Chemicals Demand 263
2 Herbal & Related Chemicals Demand 265
3 Nutrient Chemicals Demand 285
4 Bulk Minerals Demand 305
5 Bulk Vitamins Demand 313

Section IX -- Biological Chemicals
1 Biological Chemicals Demand 328
2 Vaccine Chemicals Demand by Source of Supply 329
3 Blood Derivative Chemicals Demand by Source of Supply 336

Section X -- Respiratory Chemicals
1 Respiratory Chemicals Demand 347
2 Bronchodilator Chemicals Demand by Source of Supply 352
3 Antihistamine Chemicals Demand 354
4 Corticosteroid Chemicals Demand 357
5 Antitussive Chemicals Demand 358
6 Other Respiratory Chemicals Demand 359

Section XI -- Gastrointestinal Chemicals
1 Gastrointestinal Chemicals Demand 366
2 Proton Pump Inhibitors Chemicals Demand 368
3 Anti-Emetic Chemicals Demand by Source of Supply 371
4 OTC Laxative Chemicals Demand 373
5 Gastrointestinal Anti-Inflammatory Chemicals Demand by Source of Supply 375
6 OTC Antacid Chemicals Demand 377
7 Antidiarrheal Chemicals Demand 379
8 Other Gastrointestinal Chemicals Demand by Source of Supply 382

Section XII -- Dermatological Chemicals
1 Dermatological Chemicals Demand 384
2 Antipsoriatic Chemicals Demand 389
3 Dermatological Anti-Infective Chemicals Demand 390
4 External Analgesic Chemicals Demand 394
5 Anti-Acne Chemicals Demand 397
6 Other Dermatological Chemicals Demand 399

Section XIII -- Other Pharmaceutical Chemicals
1 Other Pharmaceutical Chemicals Demand 401
2 Genito-Urinary Chemicals Demand 402
3 All Other Pharmaceutical Chemicals Demand 406

Section XIV -- Industry Structure
1 Pharmaceutical Chemicals: US Merchant Sales by Company, 2014 410
2 Selected Acquisitions & Divestitures 420
3 Selected Cooperative Agreements 423

List of Charts

Section II -- Market Environment
1 Pharmaceutical Shipments by Therapeutic Group, 2019 41

Section III -- Pharmaceutical Chemicals Overview
1 Pharmaceutical Chemicals Demand by Therapeutic Group, 2019 54

Section IV -- Central Nervous System Chemicals
1 Central Nervous System Chemicals Demand by Type, 2019 64

Section V -- Hormones & Related Chemicals
1 Hormones & Related Chemicals Demand by Type, 2019 143

Section VI -- Cardiovascular Chemicals
1 Cardiovascular Chemicals Demand by Type, 2019 200

Section VII -- Anti-Infective Chemicals
1 Anti-Infective Chemicals Demand by Type, 2019 222

Section VIII -- Nutritional Chemicals
1 Nutritional Chemicals Demand by Type, 2019 264

Section X -- Respiratory Chemicals
1 Respiratory Chemicals Demand by Type, 2019 348

Section XI -- Gastrointestinal Chemicals
1 Gastrointestinal Chemicals Demand by Type, 2019 367

Section XII -- Dermatological Chemicals
1 Dermatological Chemicals Demand by Type, 2019 385

Section XIV -- Industry Structure
1 Pharmaceutical Chemicals: US Merchant Market Share, 2014 413

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