Large Cap Pharma US & EU Outlook 2016: Maximizing Their Strength On Fewer Therapy Class, Personalized Medicine, Novel Target And Biosimilars For Future Growth
Table of Contents
AMGEN : Focus On New Biologics For Larger Market And Biosimilar to Offset Own Losses!
-Figure 1
Amgen
IMPACT OF BLINATUMOMAB TREATMENT IN MRD+ ALL PTS
-Key Pipeline Products and Development
-Key Acquisitions and Partnership in 2015
- AMGN's Commercial Strategy
-KEY MILESTONES
Biogen Idec :Growth from Tecfidera and Newly Launched Products!
-MARKETED PRODUCTS - TO GAIN STRENGTH BASED ON NEW DATA
-PIPELINE TO WATCH IN 2016/2017
-KEY MILESTONES
-Annexure I : Biogen Idec
MULTIPLE SCLEROSIS - INJECTABLE DRUGS DATA COMPARISON
Annexure II : Biogen Idec
MULTIPLE SCLEROSIS - ORAL DRUGS DATA COMPARISON
CELGENE : Innovative Strategies for Long Term Gains
KEY MILESTONES
-Development In Multiple Myeloma Franchise: Strengthening Pipeline and Sales
-Inflammation - Pipeline maturing beyond OTEZLA
-Other Products in Mid stage for Long Term Growth
Celegene: Table 1
RELAPSED AND REFRACTORY MULTIPLE MYELOMA (RRMM): RECENTLY APPROVED - DATA COMPARISON
GILEAD SCIENCES Poised to Emerge as a Leader in HCV Treatment!
Table 1
Gilead Sciences
DEVELOPMENT PIPELINE
Table 2
Gilead Sciences
DATA FROM ASTRAL -1 STUDY
Table 3
Gilead Sciences
DATA FROM ASTRAL-4 STUDY
- GILD has multiple programs running in late stage PhII/PhIII chronic HBV pts
-Liver Disease - Non-alcoholic Hepatosteatosis (NASH)
- Inflammation/Respiratory Pipeline
- ACQUISITIONS IN THE LAST ONE YEAR
KEY MILESTONES
AstraZeneca: Late Stage Pipeline maturing; Focused development on Respiratory, Psoriasis and anti-PD1 will support long term growth
-Table 1
AstraZeneca
COMPETITIVE LANDSCAPE OF BIOLOGICS IN SEVERE ASTHMA
- Table 2
AstraZeneca
ORR BY IFNG AND PD-L1 STATUS
TABLE 3
AstraZeneca
DURVALUMAB CLINICAL DEVELOPMENT PROGRAMS
-COMMERCIAL ADVANCEMENT- KEY MILESTONES TABLE
GlaxoSmithKline : Reliance On Low Margin Consumer Health And Vaccines; Unable To Revive Respiratory Franchise
-PIPELINE ANALYSIS - HIV/INFECTIOUS DISEASE
- HCV AND HBV PIPELINE - TOO EARLY TO COMMENT
- PIPELINE ANALYSIS: RESPIRATORYPIPELINE ANALYSIS - RESPIRATORY
-Other Biologics in Asthma Pipeline:
- RESPIRATORY DISEASE - COPD
-RESPIRATORY R&D BEYOND ASTHMA AND COPD
- PIPELINE ANALYSIS - VACCINES
- PIPELINE ANALYSIS - IMMUNO-INFLAMMATION
- PIPELINE ANALYSIS - RARE DISEASE
- PIPELINE ANALYSIS - ONCOLOGY
- KEY MILESTONES
Merck & Co : Anti-PD1 and HCV will remain growth drivers - going forward!
KEY POTENTIAL CATALYSTS FOR 2016
-Table 1
Merck
KEYTRUDA: LIST OF ON-GOING COMBINATION STUDIES
- Table 2
Merck
DATA FROM C-CREST 1 & 2 PART A STUDY
- 5. Januvia (sitagliptin): Positive TECOS data should help DPP-IV expand their share in a fast growing but highly genericized diabetes market
- 6. Bezlotoxumab (mAb, R, antitoxin for prevention of Clostridium difficile; C. difficile infection recurrence
- 7. Biosimilar Advancement
- OTHER LATE STAGE DRUGS - TO ADD VALUE IN 2017 AND BEYOND
- OTHER LATE STAGE DRUGS - TO ADD VALUE IN 2017 AND BEYOND
- KEY MILESTONES
MERCK KGaA : Emerging markets and anti-PD1 to lift outlook; Acquisition of Sigma-Aldrich to Stabilize Business Growth
- HEALTHCARE SEGMENT: NEXT TWO YEARS ARE MAINLY AN INVESTMENT PHASE
- HEALTHCARE SEGMENT - PIPELINE TO WATCH FOR
KEY MILESTONE TABLE
NOVARTIS:Strengthening Position In Oncology: Heart Failure And Psoriasis Therapy Will Find New Blockbusters
- NEWLY LAUNCHED DRUGS AND LATE STAGE PIPELINE- KEY PIPELINE ADVANCEMENT - FILING EXPECTED IN 2016
- Table 1
Novartis
DATA FROM PHIII STUDY OF BUPARLISIB IN BREAST CANCER (BELLE-2)
- Table 2
Novartis
EFFICACY DATA OF LCZ696 IN PARADIGM-HF
- OTHER MARKETED DRUG - STILL SHOWING HEALTHY GROWTH
- Table 3
Novartis
SANDOZ BIOSIMILAR PIPELINE STATUS
KEY MILESTONES
NOVO NORDISK: Growth is limited by pricing competitive pressures in Diabetes and
-OBESITY: A LARGE MARKRT BUT VALUE REMAINS LOW - NOVO-B PIPELINE IS EXPANDING
Figure 1
Novo Nordisk
KEY FEATURES OF COMPOUNDS IN PHASE 1 DEVELOPME FOR OBESITY
List of Tables
KEY MILESTONES (AMGN)
Data Block ( AMGN)
KEY MILESTONES (CELG)
Data Block ( CELG)
Table 1 : CELGENE -
RELAPSED AND REFRACTORY MULTIPLE MYELOMA (RRMM): RECENTLY APPROVED - DATA COMPARISON
Data Block ( BIIB)
KEY MILESTONES (BIIB)
ANNEXURE: Biogen Idec
MULTIPLE SCLEROSIS - INJECTABLE DRUGS DATA COMPARISON
Table 1 :Gilead Sciences
DEVELOPMENT PIPELINE
Table 2 :Gilead Sciences
DATA FROM ASTRAL -1 STUDY
Table 3 :Gilead Sciences
DATA FROM ASTRAL-4 STUDY
Key Milestones ( GILD)
Data Block ( GSK)
KEY MILESTONES (GSK)
Data Block Merck & Co. ( MRK)
Table 1 :Merck
KEYTRUDA: LIST OF ON-GOING COMBINATION STUDIES
Table 2 :Merck
DATA FROM C-CREST 1 & 2 PART A STUDYKEY MILESTONES (MRK)
Data Block : Merck KGaA
MILESTONE TABLE (MRK.EU)
Data Block ( NVS)
Table 1 :Novartis
DATA FROM PHIII STUDY OF BUPARLISIB IN BREAST CANCER (BELLE-2)
Table 2 :Novartis
EFFICACY DATA OF LCZ696 IN PARADIGM-HF
Table 3 :Novartis
SANDOZ BIOSIMILAR PIPELINE STATUS
KEY MILESTONES (NVS)
Data Block (NOVOB)
Table 1 :Novo Nordisk
SELECTED LONG-ACTING rFVIII AND rFIX PRODUCTS
KEY MILESTONES (NOVOB)
List of Figures
Figure 1
Amgen
IMPACT OF BLINATUMOMAB TREATMENT IN MRD+ ALL PTS
Figure 1 :Novo Nordisk KEY FEATURES OF COMPOUNDS IN PHASE 1 VELOPMENT FOR OBESITY
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