Exosome Diagnostics and Therapeutics: Global Markets

Publisher Name :
Date: 17-Nov-2021
No. of pages: 255

Report Scope:

This report represents a current and important business tool to evaluate new commercial opportunities in the exosome diagnostic, therapeutic and research tool markets. The geographic scope of this study covers the U.S. and companies worldwide. This market is complex and consists of a number of different sectors, each affected differently by scientific and technological development. The report identifies the main positive and negative factors in each sector and forecasts further trends and product and assay development in every category of this industry.

Report Includes:

- 109 tables

- An updated review of the global market for exosome diagnostics and therapeutics within the biotech research industry

- Analyses of the global market trends, with data from 2019-2020, estimates for 2021, and projections of compound annual growth rates (CAGRs) through 2026

- Estimation and forecast the overall global market size, and corresponding market share analysis by application, end-user, and geographic region

- Description of immunological compatibility, cargo capabilities and other intrinsic therapeutic activities of exosomes

- Evaluation of exosome proteins and nucleic acids as diagnostic biomarkers and discussion of their impact on microRNA, liquid biopsy and stem cell research industry

- Information on bioinformatics databases for exosome research and product development, including as ExoCarta, Vesiclopedia and EVpedia

- Impact of exosome research on specific biopharmaceutical market and summary of details for major companies researching and producing exosome products

- A relevant patent analysis on Exosome Diagnostics and Therapeutics in the U.S., Europe and Japan

- Competitive landscape of the major players operating within global market, and their global rankings and company share analysis

- Profile descriptions of the leading vendor companies including Codiak BioSciences, Evox Therapeutics, Exosome Diagnostics Inc., NonoSomiX Inc., and System Biosciences,

Summary:

Initially, exosome particles were considered "garbage" molecules secreted by cells. Today, many researchers are convinced that these tiny vesicles have unlimited potential in diagnostics and therapeutics, especially in oncology treatments.

By definition, exosomes are small membrane sacs/vesicles, approximately 30 to 100 nanometers (nm) in diameter, that are released by both healthy and cancerous cells. Substances from cell cytoplasm—such as genomic DNA, various RNA species, proteins and lipids—are encapsulated into exosomes and shed into the extracellular environment.

Research shows that all fluids in the human body contain exosomes, which can transfer cytoplasmic ingredients to other cells either locally or at distant sites. Once they reach the recipient cells, cytoplasmic ingredients can alter their biology. Thus, exosomes are being widely adopted by several end users, including hospitals, diagnostics centers and research institutions.

Scientists believe that various biomolecules in exosomes can be profiled and, consequently, may serve as useful biomarkers for different diseases. Nucleic acids such as RNA or DNA can be isolated from exosomes and further analyzed by various techniques. This is now efficiently done with the use of software provided by key players. The software used in exosome therapeutic and diagnostic applications are used for extraction, isolation and other purposes.

Overall, the market for the exosome approach can be divided into two main segments: application and end user. The overall market is estimated to be worth $REDACTED million (see Summary Table below), with the potential to increase to $REDACTED million in the next five years with a compound annual growth rate (CAGR) of REDACTED%.

This report evaluates the diagnostic market affected by exosome research and the further potential of exosome-based tests and assays. Indeed, an exosome approach represents the opportunity to expand and develop the liquid biopsy market, a growing sector in cancer diagnostics. Thus, increasing cancer prevalence worldwide generates huge opportunities for the liquid biopsy market. According to Our World in Data, about 42 million people worldwide had cancer in 2016, a more than two-fold increase from 1990.

This report also highlights developments in therapeutic and drug development sectors. There is a significant potential for using exosome depletion as a way of treating disease; cancer-generated exosomes can inhibit the immune response and stimulate angiogenesis, the development of new blood vessels. Consequently, if these exosomes are removed, tumor growth might be inhibited, and anticancer agents can work more efficiently.

In addition, there is a potential for exosomes to be used as targeted delivery vehicles of therapeutic molecules to cancer cells—for example, delivering small interfering RNA-specific molecules (siRNA) for a particular oncogene expressed in a tumor cell. According to the U.S. National Library of Medicine, cell-based exosomes have a large number of roles and targets. Also, various studies have shown that exosomes have the potential to deliver various types of cargo to target cells efficiently.

Exosome Diagnostics and Therapeutics: Global Markets

Table of Contents

Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Methodology
Intended Audience
What's New in This Report?
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports

Chapter 2 Summary and Highlights

Chapter 3 Market and Technology Background
Exosome Definition and Nomenclature
Discovery of Exosomes
Exosomes Biogenesis and Processing
Exosome Components
DNA in Exosomes
Proteins in Exosomes
RNA in Exosomes
Isolation and Detection of Exosomes
Isolation Techniques
Exosome Detection
Bioinformatic Databases for Exosome Research and Product Development
ExoCarta
Vesiclepedia
EVpedia
Exosome Function and Physiology

Chapter 4 Impact of COVID-19 on the Exosome Therapeutics Market
Overview
Current Outlook
Exosome and COVID-19 Treatment

Chapter 5 Exosome Diagnostics Market
Exosomal Proteins as Diagnostic Biomarkers
Exosomal Nucleic Acids as Diagnostic Biomarkers
Cancer Diagnostics as Market Potential for Exosome-Based Diagnostic Product Development
Prostate Cancer Diagnostics Development in the Exosome Sector
Breast Cancer as Potential for Diagnostic Development in the Exome Sector
Bladder Cancer as Potential for Diagnostic Development in the Exosome Sector
Ovarian Cancer as Potential for Diagnostic Development in the Exome Sector
Lung Cancer as Potential for Diagnostic Development in the Exosome Sector
Liquid Biopsy as Potential for Diagnostics in the Exome Sector
Exosomal Proteins and Nucleic Acids as Cancer Biomarkers in Assay Development
CNS Disorders and Neurodegeneration Diseases as Market Potential for Exosome Diagnostics Product Development
Infectious Diseases as Market Potential for Exosome Diagnostic Product Development
Cardiovascular Diseases as Market Potential for Exosome Diagnostic Product Development
Prenatal Testing as Market Potential for Exosome Diagnostic Product Development
Organ Transplantation as Market Potential for Exosome Diagnostic Product Development
Market Participants in the Exosome-Based Diagnostics Sector
Companies
Evaluation of the Current Diagnostics Sector in the Exosome Market

Chapter 6 Exosome Therapeutics Market
Intrinsic Therapeutic Activity of Exosomes
Immunological Compatibility
Cargo Capabilities
Generation of Exosome-Mediated Therapeutics
Exosome Isolation and Purification from Biofluids or Cell Culture
Engineering Exosomes as Therapeutic Delivery Vehicles
Targeting Exosomes to Specific Recipient Cells
Designing Exosomes as a Synthetic Vector
Market Potential for Exosome Therapeutics
Market Participants in the Exosome-Based Therapeutics Sector
Companies
Evaluation of the Current Therapeutics Sector in the Exosome Market

Chapter 7 Exosome Reagents and Research Tools Market
Market Overview
Isolation Methodologies and Reagents for Exosome
Detection Methodologies and Reagents for Exosome Research
Characterization Methods and Reagents for Exosome Research
Engineering Methods and Reagents for Exosome Research
Additional Products and Reagents for Exosome Research
Market Participants in Reagents and Tools for Exosome Research
Companies
Evaluation of Current Tools and Reagents in the Exosome Market

Chapter 8 Global Exosome Therapeutic and Diagnostics Market by End User
Cancer Institutes
Hospital and Diagnostic Centers
Exosomal Proteins as Diagnostic Biomarkers
Exosome Nucleic Acids as Diagnostics Biomarkers
Exosomes: Novel Biomarkers for Clinical Diagnosis
Others: Pharmaceutical and Life Science Industries and Academic Institutes

Chapter 9 Global Exosome Therapeutic and Diagnostics Market by Region
North America
Europe
Asia-Pacific
Rest of the World

Chapter 10 Impact of Exosome Research on Specific Biopharmaceutical Markets
Biomarker and Diagnostic Industry
MicroRNA Market
Liquid Biopsy Market
Stem Cell Technologies Market
Prenatal Diagnostic Market
Agriculture and Food Industry
Microfluidics and Nanotechnology
Skincare Industry

Chapter 11 Patents and Pipeline Analysis
U.S. Patent Analysis
European Patent Analysis
Japanese Patent Analysis
Pipeline Analysis

Chapter 12 Market Summary

Chapter 13 Company Profiles
CODIAK BIOSCIENCES
EVOX THERAPEUTICS LTD.
EXOSOME DIAGNOSTICS INC.
HANSABIOMED LIFE SCIENCES LTD. (LONZA)
NANOSOMIX INC.
SYSTEM BIOSCIENCES (SBI)

List of Tables
Summary Table : Global Market for Exosome Diagnostics and Therapeutics, by Application, Through 2026
Table 1 : Nomenclature of Exosome Particles
Table 2 : Publication Trend about Exosome, 2010-2020
Table 3 : Molecules Involved in Exosome Biogenesis and/or Release
Table 4 : Steps in Exosome Biogenesis and Processing
Table 5 : Proteins Essential in Exosome Biogenesis and Processing
Table 6 : Proteins Found in Exosomes
Table 7 : MicroRNA in Different Bodily Fluids, by Sample
Table 8 : Methods for Exosome Isolation
Table 9 : Distribution of Exosomes Isolation Procedures in the Studies Cataloged in ExoCarta
Table 10 : Data Cataloged in ExoCarta, 2012 and 2017
Table 11 : Data Cataloged in Vesiclepedia, 2012, 2017 and 2020
Table 12 : Data Cataloged in EVpedia, 2018
Table 13 : Comparison of Databases for Exosome Studies
Table 14 : Coronavirus Reported Cases and Deaths, by Country, as of May 2021
Table 15 : Examples of Exosomal Proteins for Clinical Diagnostic Applications
Table 16 : Examples of Exosomal MicroRNA for Clinical Diagnostic Applications
Table 17 : Characteristic Exosomal MicroRNAs in Various Biological Fluids
Table 18 : Expression Status of MicroRNAs as the Exosomal Cargo in Different Cancer Types
Table 19 : Exosomal Protein Biomarkers for Diagnosis of Different Cancers
Table 20 : Exosomal Nucleic Acid Biomarkers for Diagnosis of Different Cancers
Table 21 : Statistics for Prostate Cancer, 2021
Table 22 : Studies of microRNAs in PCa Patients
Table 23 : Global Market for Prostate Cancer Diagnostics and Related Cost, 2017 and 2022
Table 24 : Statistics for Breast Cancer, 2021
Table 25 : Global Market for Breast Cancer Diagnostics, Through 2024
Table 26 : U.S. Statistics for Bladder Cancer, 2021
Table 27 : Functions of Exosomal Noncoding RNAs and Proteins in Tumor Metastasis and Invasion
Table 28 : Global Market for Bladder Cancer Diagnostics, 2017
Table 29 : Statistics for Ovarian Cancer, 2021
Table 30 : MicroRNA Content of Ovarian Cancer-Derived Exosomes
Table 31 : Global Market for Ovarian Cancer Diagnostics, Through 2022
Table 32 : Summary of the Predictive Exosomal Components Described Until Now, Including Utility and Values Represented, by Sensitivity
Table 33 : Statistics for Lung Cancer, 2021
Table 34 : Global Market for Lung Cancer Diagnostics, 2019
Table 35 : Differences between Liquid and Tissue Biopsy for Cancer Detection and Evaluation
Table 36 : Global Market for Liquid Biopsy including Research Tools, Services and Diagnostics, Through 2025
Table 37 : Exosomal Protein Biomarkers from Bodily Fluids of Patients in Pre-Clinical and Clinical Studies
Table 38 : Exosomal Nucleic Acid Biomarkers in Pre-Clinical and Clinical Studies
Table 39 : U.S. Statistics for Alzheimer's Disease, 2021
Table 40 : Global Market for Alzheimer's Disease Therapeutics and Diagnostics, Through 2025
Table 41 : Global Statistics for Hepatitis C Infection, 2020
Table 42 : Estimated Actual New Cases of HAV (Range), 2016 and 2019
Table 43 : Global Market for Hepatitis C Diagnostics, 2017
Table 44 : U.S. Statistics for Cardiovascular Diseases, 2020
Table 45 : Global Market for Cardiovascular Diagnostics, 2020
Table 46 : Global Market for Prenatal Diagnostics, Predictive Tests and Neonatal Monitoring, Through 2023
Table 47 : Global Market for Organ and Tissue Transplantation Products and Devices, Through 2024
Table 48 : Comparison of Exosome Diagnostics' Approach to Other Liquid Biopsy Platforms
Table 49 : Main Market Participants in Exosome-Based Diagnostics Sector
Table 50 : Global Market for Exosome Diagnostics, Through 2026
Table 51 : Examples of Studies Using Extracellular Vesicles as Drug Delivery Vehicles
Table 52 : Examples of Engineering Exosome for Cargo Delivery
Table 53 : Type of Cargo and Loading Method
Table 54 : Examples of Physiological Effect of Exosome Delivery
Table 55 : Global Rankings of Top 10 Vaccine Manufacturers, 2020
Table 56 : Global Elderly Population with Alzheimer's Dementia, by Age Group, 2021
Table 57 : Global Prevalence of Tuberculosis, 2015-2019
Table 58 : Global Prevalence of Cancer, 2010-2017
Table 59 : U.S. Statistics for Burn Injuries
Table 60 : U.S. Statistics for Pressure Ulcers
Table 61 : Global Market for Aethlon Medical, 2016-2021
Table 62 : Global Market Revenue, Cost and Profits for Capricor Therapeutics, 2016-2020
Table 63 : Main Market Participants in Exosome-based Therapeutics Sector
Table 64 : Examples of Financing for Exosome-based Therapeutics, by Company, Through 2017
Table 65 : Global Market for Exosome Therapeutics, Through 2026
Table 66 : Main Steps in Exosome Research Approach
Table 67 : Examples of Commercial Kits and Reagents for Exosome Isolation
Table 68 : Frequency of Use for Each Isolation Technique for Exosome Purification
Table 69 : Range of Model Options with Zetasizer Nano ZS Instrument
Table 70 : Examples of Detection Assay
Table 71 : Examples of Antibody Providers for Exosome Research
Table 72 : Commercial RNA Extraction Kits
Table 73 : Use of Characterization Techniques for Exosome Samples
Table 74 : Examples of Purified Exosomes Commercial Products
Table 75 : Main Market Participants in Exosome Research Tools and Reagents
Table 76 : Global Market for Exosome Research Tools and Reagents, Through 2026
Table 77 : Global Market for Exosome Therapeutics and Diagnostics, by End User, Through 2026
Table 78 : Global Market for Exosomes in Cancer Institutes, by Region, Through 2026
Table 79 : Studies Employing Exosomes without Genetic Modification in Cancer Treatment
Table 80 : In Vivo and In Vitro Studies Using Modified Exosomes for Cancer Therapy
Table 81 : List of Exosomal Bioactive Molecules Involved in Various Progressions
Table 82 : Global Market for Exosomes in Hospitals and Diagnostics Centers, by Region, Through 2026
Table 83 : Exosome Proteins in Clinical Diagnostics Applications
Table 84 : Exosomes: Novel Biomarkers for Clinical Diagnosis
Table 85 : Global Market for Exosomes in the Others End User Segment, by Region, Through 2026
Table 86 : Global Market for Exosome Diagnostics and Therapeutics, by Region, Through 2026
Table 87 : Leading Cause of Deaths Related to Cancer in the UAE, by Cancer Type, 2018
Table 88 : Leading Causes of Death in Argentina, and Percent Change, 2005-2016
Table 89 : Examples of Protein Markers in Exosomes and Their Related Pathologies
Table 90 : Examples of MicroRNA Markers in Exosomes and Their Related Pathologies
Table 91 : Comparison Between Liquid Biopsy and Tissue Biopsy
Table 92 : Major Companies Researching and Producing Exosome Products
Table 93 : U.S. Patents on Exosome Diagnostics and Therapeutics, January 2015-September 2021
Table 94 : European Patents on Exosome Diagnostics and Therapeutics, January 2015-September 2021
Table 95 : Japanese Patents on Exosome Diagnostics and Therapeutics, Jan. 2016-Sept. 2021
Table 96 : Clinical Trials on Various Exosome Molecules
Table 97 : Global Market for Exosome Diagnostics and Therapeutics, by Application, Through 2026
Table 98 : Main Participants in the Exosome Market
Table 99 : Product Portfolio: Codiak Biosciences
Table 100 : Recent Development: Codiak Biosciences
Table 101 : Product Portfolio: Evox Therapeutics Ltd.
Table 102 : Recent Development: Evox Therapeutics Ltd.
Table 103 : Product Portfolio: Exosome Diagnostics Inc.
Table 104 : Recent Developments: Exosome Diagnostics Inc.
Table 105 : Product Portfolio: HansaBioMed Life Sciences Ltd. (Lonza)
Table 106 : Recent Developments: HansaBioMed Life Sciences Ltd. (Lonza)
Table 107 : Product Portfolio: Nanosomix Inc.
Table 108 : Product Portfolio: System Biosciences (SBI)

List of Figures
Summary Figure : Global Market for Exosome Diagnostics and Therapeutics, by Application, 2019-2026
Figure 1 : Publication Trends for Exosomes, 2010-2020
Figure 2 : Differential Centrifugation Process
Figure 3 : Ciliated Porous Device Designed to Isolate Exosomes, by Filtration
Figure 4 : Sieving Models for Exosome Filtration
Figure 5 : Workflow of MiRNA-Based Therapeutic Delivery Using Exosomes to Treat Alcoholic Liver Disease
Figure 6 : Global Market for Exosome Diagnostics, 2019-2026
Figure 7 : Global Prevalence of Cancer, 2010-2017
Figure 8 : Global Market for Exosome Therapeutics, 2019-2026
Figure 9 : Global Market for Exosome Research Tools and Reagents, 2019-2026
Figure 10 : Global Cancer Prevalence, 2005-2016
Figure 11 : Global Incidence of Patients with Chronic Diseases, 2005-2030
Figure 12 : U.S. Patent Documents by Published, Filed and Granted Dates, 2015-2021
Figure 13 : European Patent Documents by Published, Filed and Granted Dates, 2015-2021
Figure 14 : Japanese Patent Documents by Published, Filed and Granted Dates, 2015-2021
Figure 15 : Shares of Clinical Trials on Exosomes, by Phase, 2021
Figure 16 : Global Market for Exosome Diagnostics and Therapeutics, by Application, 2019-2026
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