Systemic Mastocytosis – Pipeline Review, H2 2012

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Date: 31-Oct-2012
No. of pages: 37
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Systemic Mastocytosis – Pipeline Review, H2 2012

Summary

Global Markets Direct’s, ‘Systemic Mastocytosis – Pipeline Review, H2 2012′, provides an overview of the indication’s therapeutic pipeline. This report provides information on the therapeutic development for Systemic Mastocytosis, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Systemic Mastocytosis. Systemic Mastocytosis – Pipeline Review, Half Year is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

- A snapshot of the global therapeutic scenario for Systemic Mastocytosis.
- A review of the Systemic Mastocytosis products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
- Coverage of products based on various stages of development ranging from discovery till registration stages.
- A feature on pipeline projects on the basis of monotherapy and combined therapeutics.
- Coverage of the Systemic Mastocytosis pipeline on the basis of route of administration and molecule type.
- Key discontinued pipeline projects.
- Latest news and deals relating to the products.

Reasons to buy

- Identify and understand important and diverse types of therapeutics under development for Systemic Mastocytosis.
- Identify emerging players with potentially strong product portfolio and design effective counter-strategies to gain competitive advantage.
- Plan mergers and acquisitions effectively by identifying players of the most promising pipeline.
- Devise corrective measures for pipeline projects by understanding Systemic Mastocytosis pipeline depth and focus of Indication therapeutics.
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
- Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline.

Systemic Mastocytosis – Pipeline Review, H2 2012

Table of Contents
Table of Contents 2
List of Tables 3
List of Figures 4
Introduction 5
Global Markets Direct Report Coverage 5
Systemic Mastocytosis Overview 6
Therapeutics Development 7
An Overview of Pipeline Products for Systemic Mastocytosis 7
Systemic Mastocytosis Therapeutics under Development by Companies 9
Systemic Mastocytosis Therapeutics under Investigation by Universities/Institutes 10
Late Stage Products 11
Comparative Analysis 11
Mid Clinical Stage Products 12
Comparative Analysis 12
Pre-Clinical Stage Products 13
Comparative Analysis 13
Systemic Mastocytosis Therapeutics - Products under Development by Companies 14
Systemic Mastocytosis Therapeutics - Products under Investigation by Universities/Institutes 15
Companies Involved in Systemic Mastocytosis Therapeutics Development 16
Novartis AG 16
Pharmacyclics, Inc. 17
AB Science 18
Systemic Mastocytosis - Therapeutics Assessment 19
Assessment by Monotherapy Products 19
Assessment by Route of Administration 20
Assessment by Molecule Type 22
Drug Profiles 24
midostaurin - Drug Profile 24
Product Description 24
Mechanism of Action 24
R&D Progress 24
PCI-45261 - Drug Profile 26
Product Description 26
Mechanism of Action 26
R&D Progress 26
masitinib - Drug Profile 27
Product Description 27
Mechanism of Action 27
R&D Progress 27
PKC-412 - Drug Profile 29
Product Description 29
Mechanism of Action 29
R&D Progress 29
thalidomide - Drug Profile 30
Product Description 30
Mechanism of Action 30
R&D Progress 30
Systemic Mastocytosis Therapeutics - Drug Profile Updates 31
Systemic Mastocytosis Therapeutics - Discontinued Products 34
Systemic Mastocytosis Therapeutics - Dormant Products 35
Appendix 36
Methodology 36
Coverage 36
Secondary Research 36
Primary Research 36
Expert Panel Validation 36
Contact Us 37
Disclaimer 37

List of Tables
Number of Products Under Development for Systemic Mastocytosis, H2 2012 7
Products under Development for Systemic Mastocytosis - Comparative Analysis, H2 2012 8
Number of Products under Development by Companies, H2 2012 9
Number of Products under Investigation by Universities/Institutes, H2 2012 10
Comparative Analysis by Late Stage Development, H2 2012 11
Comparative Analysis by Mid Clinical Stage Development, H2 2012 12
Comparative Analysis by Pre-Clinical Stage Development, H2 2012 13
Products under Development by Companies, H2 2012 14
Products under Investigation by Universities/Institutes, H2 2012 15
Novartis AG, H2 2012 16
Pharmacyclics, Inc., H2 2012 17
AB Science, H2 2012 18
Assessment by Monotherapy Products, H2 2012 19
Assessment by Stage and Route of Administration, H2 2012 21
Assessment by Stage and Molecule Type, H2 2012 23
Systemic Mastocytosis Therapeutics - Drug Profile Updates 31
Systemic Mastocytosis Therapeutics - Discontinued Products 34
Systemic Mastocytosis Therapeutics - Dormant Products 35

List of Figures
Number of Products under Development for Systemic Mastocytosis, H2 2012 7
Products under Development for Systemic Mastocytosis - Comparative Analysis, H2 2012 8
Products under Development by Companies, H2 2012 9
Products under Investigation by Universities/Institutes, H2 2012 10
Late Stage Products, H2 2012 11
Mid Clinical Stage Products, H2 2012 12
Pre-Clinical Stage Products, H2 2012 13
Assessment by Monotherapy Products, H2 2012 19
Assessment by Route of Administration, H2 2012 20
Assessment by Stage and Route of Administration, H2 2012 21
Assessment by Molecule Type, H2 2012 22
Assessment by Stage and Molecule Type, H2 2012 23

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