Strategic Development of Neural Stem & Progenitor Cell Products

Publisher Name :
Date: 15-Nov-2013
No. of pages: 141

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Neurogenesis is the process by which neurons are created. This process is most active during pre-natal development when neurogenesis is responsible for populating the growing brain. Neural stem cells (NSCs) are the self-renewing, multipotent cells that differentiate into the main phenotypes of the nervous system. These cell types include neurons, astrocytes, and oligodendrocytes. Neural progenitor cells (NPCs) are the progeny of stem cell division that normally undergo a limited number of replication cycles in vivo.

The terms neuronal and neural also need to be defined. Technically speaking, “neuronal” means “pertaining to neurons," and “neural” means “pertaining to nerves, which are the cordlike bundles of fibers made up of neurons.” Since both terms ultimately are descriptive of neurons, the scientific community uses the terms "neuronal" and "neural" interchangeably. The complexity of this issue is explored from a strategic perspective within this report.

In particular, when naming products, companies are advised to use the term “neural” rather than “neuronal,” both in reference to stem cells and progenitor cells, in order to best position products within the marketplace. Also of interest is that when “stem cell” versus “progenitor cell” publications are compared, neural/neuronal “stem cell” publication rates continue to outpace neural/neuronal “progenitor cell” publications by over 200% over a trailing two-year period.

In summary, an understanding of neural stem cell language and terminology can substantially improve product naming, strategic positioning, and the effectiveness of marketing communications. These subtleties as explored in detail within the context of this industry report.

In addition, the report focuses on: recent advances in neural stem cell research applications; research priorities by market segment; opportunities for profitable product and technology development; the competitive environment for NSC products; detailed market size analysis; market trends and metrics; five-year projections; and the needs and decision-making of NSC scientists.

Market Segments

To facilitate research resulting from these advances, a large and diverse market has emerged for neural stem cell products, platforms, and technologies. In total, the neural stem cell product marketplace is comprised of the global sales of these items. One thriving component of this marketplace is the segment of companies that sell NSC research products to scientists.

Termed “research supply companies” or “research product vendors,” large companies selling neural stem cell research products include EMD Millipore, Life Technologies, Thermo Fisher Scientific, and STEMCELL Technologies, as well as more than 40 other suppliers that range in size from multinational corporations to small specialty companies. Together, these research supply companies represent a substantial annual percentage of NSC product sales. Each of these industry participants are identified within the context of this report. As of 2013, EMD Millipore, known as Merck Millipore outside of the United States and Canada, is the leader in neural stem cell product development for the scientific community. A Canadian company, STEMCELL Technologies, is a close second in the area of NSC product development for scientists.

Within this report, profitable opportunities for NSC research product development are revealed. Specifically, competitors looking to enter the NSC research products marketplace would do well to focus their energy on the areas considered highest priority by the scientific community, specifically cell-based therapies and standardized neurotoxicity assays. Due to recent legislative initiatives, interest in the latter is expected to increase significantly in the next several years. Furthermore, companies looking to enter the NSC product market could also focus their efforts on areas in which available products are not yet optimized for use with rat or mouse neural stem cells. Or, research supply companies could choose to focus product development on areas where human neural stem cell products are not yet available, although there would be some necessary work-around due to patent restrictions. Companies could also develop products for which there is little market competition, such as hESC-derived neural progenitors, kits for analysis of NSC differentiated progeny, NSC blotting and nucleofaction kits, and PCR arrays. Finally, companies could choose to explore varied sources from which to potentially derive neural stem cell products, such as human umbilical cord blood and derivatives of neural rosette cell lines.

In addition, pharmaceutical companies also have intense interest in neural stem cell product development. Because of their plasticity, ability to develop into the main phenotypes of the nervous system, and unlimited capacity for self-renewal, NSCs have been proposed for use in a variety of pharmaceutical applications, including:


  • Neurotoxicity testing

  • Cellular therapies to treat central nervous system (CNS) conditions

  • Neural tissue engineering and repair

  • Drug target validation and testing

  • Personalized medicine

  • And more


While development of therapies that involve embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs) continue to expand, development of neural stem cell therapies has been more substantially affected by barriers to entry, including patent restrictions, the dominance of current competitors, and the complexity of neural stem cell applications. Nonetheless, within the area of NSC therapy development, there are currently three dominant competitors, which are Neural Stem, NeuroNova AB, and NeuroGeneration. In addition to those companies, there are also more than a dozen other companies actively developing NSC therapies for use in the treatment of human injury and disease.

For this reason, development of NSC products by the pharmaceutical sector also represents a thriving segment of the global NSC product marketplace. Of particular interest to this community is the potential for use of NSCs to heal tissues that have a naturally limited capacity for renewal, such human brain and spinal cord tissues.

Furthermore, within the pharmaceutical sector, development of new drugs is extremely costly and the success rate of bringing new compounds to the market is unpredictable. Therefore, it is crucial that pharmaceutical companies minimize late-stage product failures, such as suboptimal pharmacokinetic properties or unexpected neurotoxicity effects, that can can arise when candidate drugs enter the clinical testing stages. To achieve this, it would be highly desirable to test candidate drugs using in vitro assays of high human relevance as early as possible. Because NSCs have the potential to differentiate into nearly all of the main phenotypes of the nervous system, they represent an ideal cell type from which to design such neural screening assays.

In summary, the unifying factor within the NSC product marketplace is that all companies involved need to understand market forces, trends, metrics, and financials, in order to out-compete the competition and make more profitable decisions. Producing NSC products can involve complicated and confusing decisions, but it doesn't have to.

Claim this report to reveal the current and future needs of the NSC marketplace, so you can focus your marketing efforts on the most profitable products, in the most promising research areas, and within the most lucrative domestic and international markets. Your competitors would prefer you didn’t buy this report. But when you do, you’ll be gaining invaluable stem cell market insights to help you control and dominate this market.

Methods and Methodology

As a technology company, BioInformant’s standard techniques derive market data from sources that utilize high-quality primary research inputs. The following constitute the basis for our research and analysis:


  • Preliminary Research - Examination of studies that need further confirmation by the scientific community, using extensive secondary research.

  • Fill-gap Research - Selectively sampled and focused primary research as a fill-gap strategy.

  • Historic Analysis - Historic analysis of all end-user industries/markets, requiring technology and market evaluations, growth projections, and market size estimation of end-user markets.

  • Historic Supply Chain/Raw Materials Analysis - Comprehensive analysis of data for each primary market segment.

  • Data Consolidation - Merging historic end-user market data to yield consolidated primary market data.

  • Cross Linking - Primary market data (historic) is compared with resulting end-user consolidated market data and the variance in percentages between data sets is calculated by year.

  • Variance Determination - A median figure for each year with a tolerance range equal to twice the variance percentage is determined.

  • Projections - End-user markets are projected forward (typically 2013-17) based upon historic growth, technology and market trends, and primary research from the market place.

  • Variance Factorization - Consolidation of projected end-user market data to yield derived primary market data. The data is adjusted to the historic variance determinations, as above. The resulting data is further verified by confirmatory primary research.

  • Confirmatory Primary Research - Resulting data is presented from companies or individuals participating as research partners. Variations from derived data are adjusted to reflect primary research based consensus.

  • Electronically Based End-User Surveys - In addition to the methods described above, electronically based end-user surveys are utilized. Surveys are distributed to a comprehensive panel of academic and industry representatives working within the market segment of interest.


Furthermore, the market intelligence contained in this report was compiled using a broad range of sources, including:

  • Grant Funding Databases (NIH database, DoD database, and more)

  • Patent Databases (USPTO, WIPO)

  • Scientific Publication Databases (PubMed, Highwire Press, Google Scholar)

  • Product Launch Announcements (Trade Journals, Company Websites, PR News Feeds)

  • Financial Data (SEC Filings, Investor Relations Packets)

  • International Surveys (Electronically Distributed End-User Surveys)

  • And More


Finally, a rare and valuable feature of this report is an end-user survey of 240 researchers (91 U.S. / 149 International) that identify neural stem cell research as their core research focus. These findings reveal NSC researcher needs, technical preferences, key factors influencing buying decisions, and more.

Scientist survey results include:


  • Emerging trends within the NSC research sector

  • Insights into NSC product selection, purchasing decisions, and preferred providers

  • Crucial trends and unmet market needs within the NSC marketplace

  • “Tested Sentences” for selling to NSC scientists

  • Breakdown of the marketing methods used by industry participants

  • And much more


Leverage these insider insights to make effective product development decisions, create targeted marketing messages, and produce higher prospect-to-client conversion rates.

Conclusions

In summary, growth in stem cell research has exploded over the past two decades, and so the market to supply NSC products and technologies has grown to meet this huge demand. The proliferation of neural stem cell research since 1992 has opened the floodgates for forward-thinking companies to enter a unique product and technology marketplace. Neural stem and progenitor cells are the keys with which researchers are unlocking some of the most destructive human diseases and the cells' future potential is bright.

Key Findings Include:


  • Charts, Trends, and Metrics for the NSC Product Market

  • Analysis NSC Grant Rates, Scientific Publication Rates, and Patent Rates

  • Market Size Quantification for NSC Products

  • 5-Year Market Size Projections (2013-2017) for NSC Products

  • Profitable Opportunities for NSC Product and Technology Development

  • Consumer Behavioral Patterns and Preferred Providers

  • Preferred Species for NSC Research

  • Crucial Trends and Unmet Market Needs

  • End-User Survey of NSC Researchers (91 U.S. / 149 International)

Strategic Development of Neural Stem & Progenitor Cell Products

Table Of Contents

I. Background
A. Language and Definitions
1. Neurogenesis
2. Neuronal vs. Neural
3. Neural Stem Cells vs. Neural Progenitor Cells
B. Brief History
C. Regulation of Neural Stem & Progenitor Cells
1. In vitro Regulation
2. In vivo Regulation
D. Product Background

II. Applications
A. Basic Research
1. Developmental Biology
2. Adult Biology
B. Drug Discovery Applications
C. Drug Delivery Applications
D. Neural Toxicology Assessment
E. Neural Transplantation
F. Brain Tumor Research

III. Application Priorities
A. Overall
1. Cell-Based Therapies
2. Standardized Neural Toxicology Assays
B. Breakdown of Neural Stem Cell Research by Disorder
C. By Segment
1. Academic
2. Biotech
3. Pharma

IV. Patents
A. Key Neural Stem and Progenitor Cell Patents
B. Additional US Patents
C  Additional European Patents

V. Market Trend Analysis
A. Clinical Trial Analysis
1. Frequency by Year
2. Geographical Breakdown
B. Grant Rate Analysis
1. Historical Analysis
2. Future 5-Year Projection
C. Patent Rate Analysis
D. Scientific Publication Rate Analysis
1. Historical Data
2. Future 5-Year Projections
3. NSC Research Frequency Relative to Other Stem Cell Types
E. Geographical Analysis: Domestic vs. International Status
1. Number of NSC Labs, by Region of World
2. Percent of Total NSC-Specific Research Funding, by Region of World

VI. Market Size
A. Definition: NSC Product Market
B. Experimental Approach
C. NSC Research Products
1. Market Size
2. 5-Year Market Projections
D. NSC Therapy Market
1. Market Size
2. 5-Year Market Projections

VII. Competitors: Leading Suppliers Of Neural Stem Cell Products
A.  EMD Millipore
B.  STEMCELL Technologies
C.  AlphaGenix, Inc.
D.  R&D Systems
E.  Cell Applications
F.  SA Biosciences
G.  ScienCell
H.  Neuromics
I.  Amaxa
J.  Life Technologies
K.  Sigma Aldrich
L.  StemCells, Inc.
M.  Lonza
N.  BD Biosciences

VIII. Leading Pharmaceutical Companies Developing Neural STEM Cell Therapies
A. Neuralstem, Inc
B. NeuroNova AB
C. NeuroGeneration

IX. Breakdown Of Stem Cell Research Activity By Cell Type

X. Potential End-Users Of Neural Stem Cell Products
A. Academic Labs
B. Private Labs
C. Commercial Labs
D. Government Labs

XI. Product Ideas & Suggestions
A. Product Categories
1. Neural Stem Cell Lines & Neural Tissues
2. Neural Stem Cell Kits
3. Media: Maintenance, Differentiation, Expansion, & Freezing Medium
4. Growth Factors
5. Markers for Neural Stem Cells & Differentiated Progeny
6. PCR Arrays
7. Nucleofection Tools
8. Neural Toxicity Assessment
B. Product Suggestions
1. Neural Toxicity Assessment Products
2. Species-Specific Opportunities
3. Areas of Underdeveloped Competition
4. NSCs Derived from Novel Sources
5. Novelty Cells Types, such as Neural Rosette Cells (R-NSCs)

XII. Scientist Panel: Detailed End-User Survey
A. Survey Overview
B. Characterization of Market Survey Respondents
1. Geographic Distribution of Respondents
2. Respondent Breakdown by Industry Affiliation
3. Breakdown of Respondents by Duration of NSC Research Activity
C. Survey Findings
1. General Scope
2. Comparison of Providers / Brand Preferences
3. Marketing Assessment
D. Terms Used in Online Product Search

XIII. Conclusions

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