Relapsing Remitting Multiple Sclerosis (RRMS) - Pipeline Review, H2 2012

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Date: 31-Oct-2012
No. of pages: 128
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Relapsing Remitting Multiple Sclerosis (RRMS) - Pipeline Review, H2 2012

Summary

Global Markets Direct's, 'Relapsing Remitting Multiple Sclerosis (RRMS) - Pipeline Review, H2 2012', provides an overview of the indication's therapeutic pipeline. This report provides information on the therapeutic development for Relapsing Remitting Multiple Sclerosis (RRMS), complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Relapsing Remitting Multiple Sclerosis (RRMS). Relapsing Remitting Multiple Sclerosis (RRMS) - Pipeline Review, Half Year is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

- A snapshot of the global therapeutic scenario for Relapsing Remitting Multiple Sclerosis (RRMS).
- A review of the Relapsing Remitting Multiple Sclerosis (RRMS) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
- Coverage of products based on various stages of development ranging from discovery till registration stages.
- A feature on pipeline projects on the basis of monotherapy and combined therapeutics.
- Coverage of the Relapsing Remitting Multiple Sclerosis (RRMS) pipeline on the basis of route of administration and molecule type.
- Key discontinued pipeline projects.
- Latest news and deals relating to the products.

Reasons to buy

- Identify and understand important and diverse types of therapeutics under development for Relapsing Remitting Multiple Sclerosis (RRMS).
- Identify emerging players with potentially strong product portfolio and design effective counter-strategies to gain competitive advantage.
- Plan mergers and acquisitions effectively by identifying players of the most promising pipeline.
- Devise corrective measures for pipeline projects by understanding Relapsing Remitting Multiple Sclerosis (RRMS) pipeline depth and focus of Indication therapeutics.
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
- Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline.

Relapsing Remitting Multiple Sclerosis (RRMS) - Pipeline Review, H2 2012

Table of Contents
Table of Contents 2
List of Tables 7
List of Figures 8
Introduction 9
Global Markets Direct Report Coverage 9
Relapsing Remitting Multiple Sclerosis (RRMS) Overview 10
Therapeutics Development 11
An Overview of Pipeline Products for Relapsing Remitting Multiple Sclerosis (RRMS) 11
Relapsing Remitting Multiple Sclerosis (RRMS) Therapeutics under Development by Companies 13
Relapsing Remitting Multiple Sclerosis (RRMS) Therapeutics under Investigation by Universities/Institutes 16
Late Stage Products 18
Comparative Analysis 18
Mid Clinical Stage Products 19
Comparative Analysis 19
Early Clinical Stage Products 20
Comparative Analysis 20
Pre-Clinical Stage Products 21
Comparative Analysis 21
Relapsing Remitting Multiple Sclerosis (RRMS) Therapeutics - Products under Development by Companies 22
Relapsing Remitting Multiple Sclerosis (RRMS) Therapeutics - Products under Investigation by Universities/Institutes 23
Companies Involved in Relapsing Remitting Multiple Sclerosis (RRMS) Therapeutics Development 24
F. Hoffmann-La Roche Ltd. 24
Abbott Laboratories 25
Biogen Idec Inc. 26
Eli Lilly and Company 27
GlaxoSmithKline plc 28
MedImmune LLC 29
XenoPort, Inc. 30
Actelion Ltd 31
Ono Pharmaceutical Co., Ltd. 32
Teva Pharmaceutical Industries Limited 33
Genmab A/S 34
Momenta Pharmaceuticals, Inc. 35
Opexa Therapeutics, Inc. 36
Allozyne, Inc. 37
Adeona Pharmaceuticals, Inc. 38
Receptos, Inc. 39
Synthon BV 40
Celtaxsys, Inc. 41
Relapsing Remitting Multiple Sclerosis (RRMS) - Therapeutics Assessment 42
Assessment by Monotherapy Products 42
Assessment by Combination Products 43
Assessment by Route of Administration 44
Assessment by Molecule Type 46
Drug Profiles 48
laquinimod sodium - Drug Profile 48
Product Description 48
Mechanism of Action 48
R&D Progress 48
laquinimod sodium - Drug Profile 50
Product Description 50
Mechanism of Action 50
R&D Progress 50
tabalumab - Drug Profile 52
Product Description 52
Mechanism of Action 52
R&D Progress 52
daclizumab - Drug Profile 54
Product Description 54
Mechanism of Action 54
R&D Progress 54
firategrast - Drug Profile 56
Product Description 56
Mechanism of Action 56
R&D Progress 56
ponesimod - Drug Profile 58
Product Description 58
Mechanism of Action 58
R&D Progress 58
PEGylated Interferon Beta-1A - Drug Profile 59
Product Description 59
Mechanism of Action 59
R&D Progress 59
estriol - Drug Profile 60
Product Description 60
Mechanism of Action 60
R&D Progress 60
Tcelna - Drug Profile 61
Product Description 61
Mechanism of Action 61
R&D Progress 61
MEDI-551 - Drug Profile 63
Product Description 63
Mechanism of Action 63
R&D Progress 63
ONO-4641 - Drug Profile 65
Product Description 65
Mechanism of Action 65
R&D Progress 65
recombinant IFN Beta-1b - Drug Profile 66
Product Description 66
Mechanism of Action 66
R&D Progress 66
dimethyl fumarate - Drug Profile 68
Product Description 68
Mechanism of Action 68
R&D Progress 68
Ocrelizumab + Methylprednisolone - Drug Profile 70
Product Description 70
Mechanism of Action 70
R&D Progress 70
ofatumumab - Drug Profile 72
Product Description 72
Mechanism of Action 72
R&D Progress 72
Epigallocatechin Gallate - Drug Profile 76
Product Description 76
Mechanism of Action 76
R&D Progress 76
AZ-01 - Drug Profile 78
Product Description 78
Mechanism of Action 78
R&D Progress 78
Memantine - Drug Profile 79
Product Description 79
Mechanism of Action 79
R&D Progress 79
Interferon beta 1b + Atorvastatin - Drug Profile 80
Product Description 80
Mechanism of Action 80
R&D Progress 80
abatacept - Drug Profile 81
Product Description 81
Mechanism of Action 81
R&D Progress 81
XP-23829 - Drug Profile 82
Product Description 82
Mechanism of Action 82
R&D Progress 82
RPC-1063 - Drug Profile 83
Product Description 83
Mechanism of Action 83
R&D Progress 83
alemtuzumab - Drug Profile 85
Product Description 85
Mechanism of Action 85
R&D Progress 85
NT-KO-003 - Drug Profile 86
Product Description 86
Mechanism of Action 86
R&D Progress 86
Peptide-Coupled Peripheral Blood Mononuclear Cells - Drug Profile 88
Product Description 88
Mechanism of Action 88
R&D Progress 88
Trimesta + Norethindrone - Drug Profile 89
Product Description 89
Mechanism of Action 89
R&D Progress 89
Glatiramer Acetate - Drug Profile 90
Product Description 90
Mechanism of Action 90
R&D Progress 90
CTX-4398 - Drug Profile 91
Product Description 91
Mechanism of Action 91
R&D Progress 91
BG-12 + Interferon Beta - Drug Profile 92
Product Description 92
Mechanism of Action 92
R&D Progress 92
T Cell Vaccination - Drug Profile 93
Product Description 93
Mechanism of Action 93
R&D Progress 93
Boswellic Acids - Drug Profile 94
Product Description 94
Mechanism of Action 94
R&D Progress 94
BG-12 + Glatiramer Acetate - Drug Profile 95
Product Description 95
Mechanism of Action 95
R&D Progress 95
Relapsing Remitting Multiple Sclerosis (RRMS) Therapeutics - Drug Profile Updates 96
Relapsing Remitting Multiple Sclerosis (RRMS) Therapeutics - Dormant Products 115
Relapsing Remitting Multiple Sclerosis (RRMS) - Product Development Milestones 116
Featured News & Press Releases 116
Oct 04, 2012: XenoPort Reports Favorable Metabolism And Pharmacokinetics Of XP23829 In Phase I Trial 116
Sep 19, 2012: Biogen Idec Announces Publication Of Results From Two Phase III Trials Of Oral BG-12 In New England Journal Of Medicine 117
Aug 08, 2012: Teva To Initiate Third Phase III Trial Of Oral Laquinimod For Treatment Of Relapsing Remitting Multiple Sclerosis 119
Jul 23, 2012: XenoPort Initiates Phase I Study For Potential Treatment Of Multiple Sclerosis And Psoriasis 119
Jul 17, 2012: European Medicines Agency Accepts Start Of Scientific Review Of Marketing Authorization Application For Active Biotech's Laquinimod In Relapsing-Remitting Multiple Sclerosis 120
Jul 16, 2012: Enzon Presents Pre-Clinical Data On Controlled Release Of PEGylated Interferon-Beta-1b And PEGylated Anti-TNF-a Antibody Fragment 120
May 31, 2012: Novartis Announces Data From Phase III Gilenya Study For Treatment Of Relapsing-Remitting Multiple Sclerosis 121
May 24, 2012: XenoPort Submits Investigational New Drug Application For XP23829 As Potential Treatment Of RRMS 122
May 14, 2012: Biogen Idec's AVONEX Dosing Innovations For Treatment Of Multiple Sclerosis Now Available in US 123
Apr 26, 2012: Biogen And Elan Highlight New Data Of TYSABRI At AAN Annual Meeting 124
Appendix 127
Methodology 127
Coverage 127
Secondary Research 127
Primary Research 127
Expert Panel Validation 127
Contact Us 128
Disclaimer 128

List of Tables
Number of Products Under Development for Relapsing Remitting Multiple Sclerosis (RRMS), H2 2012 11
Products under Development for Relapsing Remitting Multiple Sclerosis (RRMS) - Comparative Analysis, H2 2012 12
Number of Products under Development by Companies, H2 2012 14
Number of Products under Development by Companies, H2 2012 (Contd..1) 15
Number of Products under Investigation by Universities/Institutes, H2 2012 17
Comparative Analysis by Late Stage Development, H2 2012 18
Comparative Analysis by Mid Clinical Stage Development, H2 2012 19
Comparative Analysis by Early Clinical Stage Development, H2 2012 20
Comparative Analysis by Pre-Clinical Stage Development, H2 2012 21
Products under Development by Companies, H2 2012 22
Products under Investigation by Universities/Institutes, H2 2012 23
F. Hoffmann-La Roche Ltd., H2 2012 24
Abbott Laboratories, H2 2012 25
Biogen Idec Inc., H2 2012 26
Eli Lilly and Company, H2 2012 27
GlaxoSmithKline plc, H2 2012 28
MedImmune LLC, H2 2012 29
XenoPort, Inc., H2 2012 30
Actelion Ltd, H2 2012 31
Ono Pharmaceutical Co., Ltd., H2 2012 32
Teva Pharmaceutical Industries Limited, H2 2012 33
Genmab A/S, H2 2012 34
Momenta Pharmaceuticals, Inc., H2 2012 35
Opexa Therapeutics, Inc., H2 2012 36
Allozyne, Inc., H2 2012 37
Adeona Pharmaceuticals, Inc., H2 2012 38
Receptos, Inc., H2 2012 39
Synthon BV, H2 2012 40
Celtaxsys, Inc., H2 2012 41
Assessment by Monotherapy Products, H2 2012 42
Assessment by Combination Products, H2 2012 43
Assessment by Stage and Route of Administration, H2 2012 45
Assessment by Stage and Molecule Type, H2 2012 47
Relapsing Remitting Multiple Sclerosis (RRMS) Therapeutics - Drug Profile Updates 96
Relapsing Remitting Multiple Sclerosis (RRMS) Therapeutics - Dormant Products 115

List of Figures
Number of Products under Development for Relapsing Remitting Multiple Sclerosis (RRMS), H2 2012 11
Products under Development for Relapsing Remitting Multiple Sclerosis (RRMS) - Comparative Analysis, H2 2012 12
Products under Development by Companies, H2 2012 13
Products under Investigation by Universities/Institutes, H2 2012 16
Late Stage Products, H2 2012 18
Mid Clinical Stage Products, H2 2012 19
Early Clinical Stage Products, H2 2012 20
Pre-Clinical Stage Products, H2 2012 21
Assessment by Monotherapy Products, H2 2012 42
Assessment by Combination Products, H2 2012 43
Assessment by Route of Administration, H2 2012 44
Assessment by Stage and Route of Administration, H2 2012 45
Assessment by Molecule Type, H2 2012 46
Assessment by Stage and Molecule Type, H2 2012 47

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