PharmaPoint: Hepatitis C Virus - China Drug Forecast and Market Analysis to 2022

Publisher Name :
Date: 31-May-2013
No. of pages: 106

Summary

GlobalData has released its new Country report, "PharmaPoint: Hepatitis C Virus - China Drug Forecast and Market Analysis to 2022". Hepatitis C is a liver infection caused by the hepatitis C virus (HCV) that results in acute or chronic presentation. The disease is often asymptomatic, but infected patients may experience fatigue, joint pain, itchy skin or jaundice. There is no effective vaccine against HCV, so the market is driven by therapeutics. Currently, drug combinations containing pegylated interferon (e.g., Roche's Pegasys and Merck's PegIntron) and ribavirin (e.g., Roche's Copegus and Merck's Rebetol) are used to treat HCV infection. Patients infected with HCV genotype 1 can also have a protease inhibitor added to their combination therapy, such as Merck's Victrelis (boceprevir) or Vertex's Incivek (telaprevir). The entrance of next-generation HCV therapies is expected to fundamentally change the HCV treatment algorithm. GlobalData expects a dramatic shift favoring the uptake of interferon-free regimens due to their more tolerable side-effect profiles and decreased duration of therapy compared with the current standard of care.

The anticipated main drivers of market growth during the forecast period include an increased awareness of the disease and the country's tendency to treat HCV once it is diagnosed.

Standard interferon drugs are the current market leader in China. GlobalData's primary research revealed that Merck's Intron A (interferon alfa-2b) is the most commonly prescribed standard interferon in China, but that Roferon-A (interferon alfa-2a) and Kadmon's Infergen (interferon alfacon-1) are also used frequently. Standard interferon requires more-frequent dosing than peginterferon alpha, but standard interferon has been able to retain its market share in China in the face of competition from peginterferon due to its lower cost.

Scope


  • Overview of the HCV including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.

  • Detailed information on the key drugs in China including product description, safety and efficacy profiles as well as a SWOT analysis.

  • Sales forecast for the top drugs in China from 2012-2022.

  • Analysis of the impact of key events as well the drivers and restraints affecting China HCV market.


Reasons to buy

  • Understand and capitalize by identifying products that are most likely to ensure a robust return

  • Stay ahead of the competition by understanding the changing competitive landscape for HCV

  • Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential

  • Make more informed business decisions from insightful and in-depth analysis of drug performance

  • Obtain sales forecast for drugs from 2012-2022 in China

PharmaPoint: Hepatitis C Virus - China Drug Forecast and Market Analysis to 2022

Table Of Contents

1 Table of Contents 4
1.1 List of Tables 7
1.2 List of Figures 8

2 Introduction 9
2.1 Catalyst 9
2.2 Related Reports 9
2.3 Upcoming Related Reports 10

3 Disease Overview 11
3.1 Etiology and Pathophysiology 12
3.1.1 Etiology 12
3.1.2 Pathophysiology 15
3.1.3 Prognosis 16
3.2 Symptoms 16

4 Disease Management 17
4.1 Diagnosis and Referral Overview 17
4.2 Treatment Overview 18
4.3 China 21
4.3.1 Diagnosis 21
4.3.2 Clinical Practice 21

5 Competitive Assessment 22
5.1 Overview 22
5.2 Strategic Competitor Assessment 22
5.3 Product Profiles - Major Brands 24
5.3.1 Incivek (telaprevir) 24
5.3.2 Pegasys (peginterferon alfa-2a) 29
5.3.3 PegIntron (peginterferon alfa-2b) 34
5.3.4 Copegus, Rebetol, and Generic Ribavirin 38
5.3.5 Therapeutic Class: Interferon 41

6 Opportunity and Unmet Need 42
6.1 Overview 42
6.2 Unmet Needs 43
6.2.1 Unmet Need: Treatment Tolerability 43
6.2.2 Unmet Need: Efficacy 43
6.2.3 Unmet Need: Disease Awareness 44
6.2.4 Unmet Need: Treatment Cost 45
6.2.5 Unmet Need: Shorter Treatment Duration 45
6.2.6 Unmet Need: Simplified Treatment Regimens 46
6.3 Unmet Needs Gap Analysis 47
6.4 Opportunities 48
6.4.1 Opportunity: Pan-genotypic HCV Regimen 48
6.4.2 Opportunity: Treatment of Underrepresented Patient Populations 48
6.4.3 Opportunity: Involvement of Immune System 49

7 Pipeline Assessment 50
7.1 Overview 50
7.2 Promising Drugs in Clinical Development 51
7.2.1 Simeprevir 53
7.2.2 Faldaprevir and Faldaprevir plus BI 207127 61
7.2.3 Daclatasvir and Daclatasvir plus Asunaprevir 69
7.2.4 Other Drug Classes 77

8 Market Outlook 80
8.1 China 80
8.1.1 Forecast 80
8.1.2 Key Events 84
8.1.3 Drivers and Barriers 84

9 Appendix 86
9.1 Bibliography 86
9.2 Abbreviations 94
9.3 Methodology 96
9.4 Forecasting Methodology 96
9.4.1 Percent Drug-Treated Patients 96
9.4.2 Patient Warehousing 97
9.4.3 Drugs Included in Each Therapeutic Class 97
9.4.4 General Pricing Assumptions 97
9.4.5 Individual Drug Assumptions 98
9.4.6 Generic Erosion 100
9.4.7 Selection of Pipeline Agents 100
9.4.8 Pricing of Pipeline Agents 100
9.5 Physicians and Specialists Included in this Study 102
9.6 Survey of Prescribing Physicians 104
9.7 About the Authors 105
9.7.1 Author 105
9.7.2 Global Head of Healthcare 105
9.8 About GlobalData 106
9.9 Contact Us 106
9.10 Disclaimer 106

List Of Tables

Table 1: Modes of HCV Transmission 15
Table 2: Symptoms of Acute and Chronic HCV Infection 16
Table 3: HCV Genotypes Present in the 9MM 18
Table 4: General Standard of Care by HCV Genotype 18
Table 5: Treatment Guidelines for HCV by Country 20
Table 6: Most-Prescribed Drugs for HCV by Class in the Global Markets, 2013 20
Table 7: Leading Treatments for HCV, 2012 23
Table 8: Product Profile - Incivek 25
Table 9: Efficacy of Incivek in Treatment-Naïve Patients (ADVANCE Trial) 25
Table 10: Efficacy of Incivek in Treatment-Experienced Patients (REALIZE Trial) 26
Table 11: Common Incivek Adverse Drug Reactions 27
Table 12: Incivek SWOT Analysis, 2012 28
Table 13: Product Profile - Pegasys 30
Table 14: Antiviral Efficacy of Peginterferon alfa-2a Compared with Interferon alfa-2b 31
Table 15: Pegasys SWOT Analysis, 2012 33
Table 16: Product Profile - PegIntron 35
Table 17: Antiviral Efficacy of Peginterferon alfa-2b Compared with Interferon alfa-2b 35
Table 18: PegIntron SWOT Analysis, 2012 37
Table 19: Effect of Addition of Ribavirin to Peginterferon HCV Therapy 39
Table 20: Ribavirin SWOT Analysis, 2012 40
Table 21: Summary of Minor Therapeutic Classes, 2012 41
Table 22: Overall Unmet Needs - Current Level of Attainment 42
Table 23: Clinical Unmet Needs - Gap Analysis, 2012 47
Table 24: HCV - Pipeline, 2012 51
Table 25: Comparison of Therapeutic Classes in Development for HCV, 2012 52
Table 26: Janssen's Simeprevir Ongoing Clinical Trials of Interest 54
Table 27: Product Profile - Simeprevir 55
Table 28: PILLAR Clinical Trial Results 55
Table 29: Adverse Events Observed in PILLAR Clinical Trial 56
Table 30: Simeprevir SWOT Analysis, 2012 60
Table 31: Boehringer Ingelheim's Faldaprevir Ongoing Clinical Trials of Interest 62
Table 32: Product Profile - Faldaprevir 63
Table 33: Efficacy of Interferon-Free Faldaprevir Regimen (SOUND-C2 Trial) 63
Table 34: Faldaprevir SWOT Analysis, 2012 68
Table 35: Bristol-Myers Squibb's Daclatasvir Ongoing Clinical Trials of Interest 70
Table 36: Product Profile - Daclatasvir 71
Table 37: Efficacy of Daclatasvir in Treatment-Naïve Patients (COMMAND-1 Trial) 71
Table 38: Daclatasvir and Asunaprevir Quad Therapy Efficacy 72
Table 39: Daclatasvir Triple Therapy Adverse Events 73
Table 40: Daclatasvir SWOT Analysis, 2012 76
Table 41: Comparison of Peginterferon lambda with Peginterferon alfa (EMERGE Trial) 77
Table 42: Efficacy of Alisporivir in Treatment-Naïve HCV GT2/3 Patients (VITAL-1 Trial) 78
Table 43: Sales Forecasts ($m) for HCV in China, 2012-2022 82
Table 44: Key Events Impacting Sales for HCV in China, 2012 84
Table 45: Chinese HCV Market - Drivers and Barriers, 2012 84
Table 46: Physicians Surveyed, By Country 104

List Of Figures

Figure 1: HCV Genome and Polyprotein Composition 12
Figure 2: HCV Lifecycle Overview 13
Figure 3: Competitive Assessment of Late-Stage Pipeline Agents in HCV, 2012-2022 51
Figure 4: Sales for HCV Therapeutics in China by Drug Class, 2012-2022 83

  • Schottky Diode Industry Research – 2015 Global and Chinese Market Overview
    ‘2015 Schottky Diode Industry Report – Global and Chinese Market Scenario’ is a top-notch research report, delivering premium industry insights and explanations of complex business scenarios. The report systematically articulates various growth prospects and current market challenges being faced by the existing industry players. The research report also drafts a meticulous business forecast that provides [...]
  • Codeine (CAS 76-57-3) Industry Research Report – 2009-2019 Market Forecast
    ‘Global and Chinese Codeine (CAS 76-57-3) Industry, 2009-2019 Market Research Report’, a systematically structured research report, that aims to deliver a detailed understanding of vivid market scenarios prevalent in the Codeine (CAS 76-57-3) industry to the user.  The report articulates various sections that thoroughly describe all key-aspects of the Codeine (CAS 76-57-3) industry. The report [...]
  • Global and Chinese Mainframe Banking Industry 2015 Outlook
    2015 Banks Mainframe Industry Report -Global and Chinese Market is a detailed market research report, delivering premium industry insights and analyzing the growth prospects of the industry over the forecast period of 2015-2020. The systematically structured sections of the research report, aims at conveying a strong business understanding to the user, enhancing the decision making [...]
  • Global and Chinese Market Situation of Milk Infant Formula Industry Over the Period of 2009-2019
    ‘Market Research Report on Global and Chinese Milk Infant Formula Industry, 2009-2019’ a comprehensive market study, that analyses various market landscape and key-aspects of the industry, delivering premium business insight and thorough understanding of the Global and Chinese market conditions to the user. Industry experts have methodologically structured the elaborative sections of the research report, [...]
  • Tunnel Boring Machine Market Global & Chinese (Capacity, Value, Cost or Profit) 2019 Forecasts
    Market Research Report on Global and Chinese Tunnel Boring Machines (TBM) Industry, 2009-2019, a comprehensive market study, that provides a complete understanding of vivid market scenarios prevalent in the Tunnel boring machine (TBM) market. Industry experts have systematically organized the various sections of the report that effectively assist business professionals in result oriented decision making [...]
    • The Oil Drilling Rig Industry
    • The Oil Drilling Rig Industry is characterized with a few typical work specific to this industry only. The work begins with the search for new oil basins or construction of wells. During this time the services of drilling contractors and se…

    • HER2-Negative Breast Cancer’s Therapeutic Market
    • HER2-Negative Breast Cancer is the most common form of cancer occurring in women. The long term survival of patients diagnosed with HER2-Negative Breast Cancer depends solely on its early detection as till now there is no medicine that can …

    • The Market of Plate Heat Exchanger
    • Plate heat exchanger is not only very useful but its also easy to maintain, its compact design makes it more efficient, the product is highly cost-efficient and also the materials of this product are easily available. There are some limitat…

    • The Industry of Binding Machines
    • Binding of books and papers is one of the most important aspect of buying and selling books and thus the demand of binding machines. There are different kinds of binding machines available in the market. The binding type determines the bind…

    • The Boom In Women Infertility Market
    • Infertility is an abnormality in the regular functioning of the human reproductive system. Anyone of male or female might be suffering from this issue. Infertility in woman is caused by either a genetical factor or factors such as aging or …

  • Hepatitis Market to 2017 - Strong Hepatitis-C Pipeline, Large Number of Strategic Consolidations and Cost Effective Treatments will Drive the Market
    Published: 02-Jan-2012        Price: US 3500 Onwards        Pages: 114
    GBI Research’s new report, “Hepatitis Market to 2017 - Strong Hepatitis-C Pipeline, Large Number of Strategic Consolidations and Cost Effective Treatments will Drive the Market”, provides in-depth analysis of the unmet need, drivers and barriers impacting the global hepatitis market. The report analyzes the hepatitis markets in the US, the top five countries in Europe (the UK, Germany, France, Italy and Spain) and Japan. Treatment usage patterns, sales, prices and volumes are forecast until 2017......
  • Global Hepatitis C Drugs Market 2011-2015
    Published: 11-May-2012        Price: US 1500 Onwards        Pages: 37
    TechNavio's analysts forecast the Global Hepatitis C Drugs market to grow at a CAGR of 28 percent over the period 2011-2015. One of the key factors contributing to this market growth is the increasing prevalence of hepatitis C infection. The Global Hepatitis C Drugs market has also been witnessing the shift of treatments from multiple drug therapy to single drug therapy. However, the virus developing resistance to the drugs could pose a challenge to the growth of this market. TechNa......
  • Hepatitis - Pipeline Review, H2 2012
    Published: 31-Aug-2012        Price: US 2500 Onwards        Pages: 356
    Global Markets Direct’s, ''Hepatitis - Pipeline Review, H2 2012'', provides an overview of the Hepatitis therapeutic pipeline. This report provides information on the therapeutic development for Hepatitis, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Hepatitis. ''Hepatitis - Pipeline Review, H2 2012'' is built using data and information sourced from Global Markets Direct’s propr......
  • Hepatitis C - Pipeline Review, H2 2012
    Published: 31-Aug-2012        Price: US 2500 Onwards        Pages: 273
    Global Markets Direct’s, ''Hepatitis C - Pipeline Review, H2 2012'', provides an overview of the Hepatitis C therapeutic pipeline. This report provides information on the therapeutic development for Hepatitis C, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Hepatitis C. ''Hepatitis C - Pipeline Review, H2 2012'' is built using data and information sourced from Global Markets Dire......
  • Hepatitis B - Pipeline Review, H2 2012
    Published: 28-Nov-2012        Price: US 2000 Onwards        Pages: 269
    Hepatitis B - Pipeline Review, H2 2012 Summary Global Markets Direct's, 'Hepatitis B - Pipeline Review, H2 2012', provides an overview of the indication's therapeutic pipeline. This report provides information on the therapeutic development for Hepatitis B, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Hepatitis B. Hepatitis B - Pipeline Review, Half Year is built using dat......
  • Hepatitis D - Pipeline Review, H2 2012
    Published: 26-Dec-2012        Price: US 2000 Onwards        Pages: 47
    Hepatitis D - Pipeline Review, H2 2012 Summary Global Markets Direct's, 'Hepatitis D - Pipeline Review, H2 2012', provides an overview of the indication's therapeutic pipeline. This report provides information on the therapeutic development for Hepatitis D, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Hepatitis D. Hepatitis D - Pipeline Review, Half Year is built using dat......
  • 2013 Deep Research Report on China Hepatitis B Vaccine Industry
    Published: 08-Jan-2013        Price: US 2000 Onwards        Pages: 173
    This is a professional and depth research report on China Hepatitis B Vaccine industry. This report has firstly introduced Hepatitis B Vaccine definition classification industry chain etc related information. Then introduced Hepatitis B Vaccine manufacturing technology and product specifications, And then summary statistics China major Hepatitis B Vaccine manufacturers 2009-2013 Hepatitis B Vaccine capacity production supply demand shortage and Hepatitis B Vaccine selling price cost gross margin......
  • Therapeutic Class Report Overview : Hepatitis C Virus Infection
    Published: 04-Feb-2013        Price: US 1000 Onwards        Pages: 31
    The launch of Protease inhibitors’ (PIs) created a wave in 2011-12 and accelerated the pace of innovation and impressive Sustained Virologic Response (SVR) rates by oral IFN free drug combinations have raised the bar and the expectations of pts, physicians and investors.  Freedom from IFN, treating all genotypes and betting on vaccines could bring a sea of change in the HCV therapy class area in the future. Roche set the trend ......
  • Hepatitis C - Pipeline Review, H1 2013
    Published: 28-Feb-2013        Price: US 2500 Onwards        Pages: 257
    Hepatitis C - Pipeline Review, H1 2013 Summary Global Markets Direct's, 'Hepatitis C - Pipeline Review, H1 2013', provides an overview of the indication's therapeutic pipeline. This report provides information on the therapeutic development for Hepatitis C, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Hepatitis C. Hepatitis C - Pipeline Review, Half Year is built using dat......
  • SERVICES
    Value for Money
    We believe in "optimum utilization of available budget and resources". While servicing our clients' (your) market research requirements, we keep the same approach in focus to help you get the best value for your $$s.
    Ever Growing Inventory
    Ranging from the smallest feasible / required data (datasheets, data facts, SWOT analysis, company profiles, etc) to full research reports that help you make decisions, our inventory is updated almost on a daily basis with the latest industry reports from domain experts that track more than 5000 niche sectors.
    One Stop Solution
    Need a custom research report on medical devices market? Require all available business intelligence on 3D printing industry? Exploring F&B sector of a particular country/region? RnRMarketResearch.com is your one-stop-solution to all market intelligence needs. We not only offer custom research and consulting services, we also "bundle" reports to meet your needs and help you fetch the data analysis you require for your business.
    Dedicated Client Engagement
    Not limited to only "finding" relevant reports for you, our client engagement team dedicates its efforts to understand your "business need" and accordingly maps available research data to help you move forward. Call "your" client engagement executive any time of your day and get your questions answered in order to make the correct business decision.
    Saving Time and Efforts
    Simply share your research requirement details with us and let us do all the hard work to find required intelligence for you. When you add up our "one stop solution" and "dedicated client engagement" services mentioned above, you obviously know the time and effort saving you do by working with us.
    Payment Flexibility
    Working with Fortune 500 organizations, we understand the importance of being flexible for payments. Share your payment terms with us and we will surely match up to them to ensure you get access to required business intelligence data without having to wait for the payment to be done.
    Post-Purchase Research Support
    Have questions after reading a report / datasheet bought through us? Not sure about the methodology used for data available in the research? Talk to us / Share your questions with us and if required, we will connect you with the analyst(s)/author(s) of the report(s) and ensure you get satisfactory answers for the same. Need more data / analysis / report(s) on the topic of your research/project? The RnRMarketResearch.com team is here for you 24X7 to support you with your post-purchase requirements. Subscription Offers & Packages (Get in touch with us for more details - [email protected] / +1 888 391 5441 )
    • Ad Hoc
    • Pay - as - you - go / Bucket Subscriptions
    • Fixed Cost for #of reports
    • Customize / Personalize as per your needs