Cell Culture – Rising Demand for Biologics and Growing Visibility of Approval Pathway for Biosimilars will Create Growth Opportunities

Publisher Name :
Date: 9-Nov-2012
No. of pages: 75

GBI Research, the leading business intelligence provider, has released its latest research “Cell Culture Rising Demand for Biologics and Growing Visibility of Approval Pathway for Biosimilars will Create Growth Opportunities”, which provides in-depth analysis on the processes, drivers and barriers of the cell culture market. The report analyzes the role of biopharmaceutical products that basically provide enhancement to media, sera, reagents and cell culture market. Major manufacturing technologies involved in the cell culture technology have been detailed in the report. Furthermore, the report provides competitive benchmarking for the leading players that shape the global media, sera, reagent and overall cell culture market.

This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GBI Research’s team of industry experts.

Cell culture technology is used to carry out processes external to the natural environment by maintaining controlled environments which enable the growth of various cell cultures for use in medicine and research. The processes is related to methods involved in the development of tissue or organ cultures. Multicellular eukaryotic cells from animals are usually preferred for cell culture as they provide standard characteristics for growing environments. Plant cells are the second choice for culture technology, while fungi, bacteria, protists and others are also used for the developmental process.

The development of recombinant methods involves genetic manipulation and restructuring of DNA or genes. Genetic recombination usually takes place in a biological environment, while DNA recombination occurs either during a repair response or experiments using in vitro studies. This is also known as genetic engineering technology and was developed at the end of the twentieth century. This method was further developed for large-scale cell culture production and was found to be helpful in protein synthesis processes, such as insulin production.

GBI Research indicates that the cell culture market is growing continuously due to increased demand for biopharmaceutical products. The introduction of biosimilars across various geographies in the forecast period on a large scale will boost the cell culture market, rapidly. Despite concerns about low flexibility for manufacturing quantities and other factors, the higher efficacy of the end products will drive its growth in the future.

Scope

  • Analysis of various technologies involved in cell culture and the key associated manufacturing processes involved
  • Key drivers and barriers that have a significant impact on the cell culture market.
  • Major equipment, cell banks and cell lines for cell culture development have been analyzed
  • Annualized market data for the media, sera, reagents and global cell culture market from 2004 to 2011, forecast forward to 2018, have been provided in the report.
  • Major players in the cell culture market are enlisted providing their company overview and company roles in the market.

Reasons to buy

  • Align your product portfolio to the markets with high growth potential
  • Develop market-entry and market expansion strategies by identifying the leading therapeutic segments and geographic markets poised for strong growth
  • Develop strategic initiatives by understanding the key focus areas of leading companies
  • Exploit in-licensing and out-licensing opportunities by identifying products that could fill portfolio gaps

Cell Culture – Rising Demand for Biologics and Growing Visibility of Approval Pathway for Biosimilars will Create Growth Opportunities

Table of Contents

1 Table of Contents 5
1.1 List of Tables 7
1.2 List of Figures 8

2 Cell Culture - Introduction 9
2.1 Introduction 9

3 Cell Culture - Overview 10
3.1 Overview 10
3.2 Cell Lines 10
3.3 Application of Cell Lines 10
3.3.1 Characteristics of Cell Lines 10
3.4 Selective Cell Lines 11
3.4.1 Chinese Hamster Ovary 11
3.4.2 SP2/0 and NS0 11
3.4.3 HEK 293 and PER. C6 11
3.5 Transformational Approach of Transgenic Model 12
3.5.1 Transgenic DNA Preparation 12
3.5.2 Insertion of the Transgenic DNA into Animals 12
3.5.3 Clone and Integrity Verification of the Transgene 13
3.5.4 DNA Purification and Establishing a Screening Method 13
3.5.5 Breeding and Analysis of Transgenic Rodents 13
3.6 Stem Cell Research has Enormous Potential for Cell Culture 14
3.6.1 Applications of Stem Cell Research 14
3.6.2 Stem Cell Research Market Analysis 15
3.7 Fermentation Methods 16
3.7.1 Fed-Batch Fermentation 17
3.7.2 Important Factors for Regulating Cell Culture 18
3.8 Fermenters and Bioreactors 19
3.8.1 Bioreactor 19
3.8.2 Selection of Bioreactors 19
3.8.3 Batch Bioreactor 20
3.8.4 Continuous Bioreactor 21
3.8.5 Submerged Bioreactors — Stirred Tank 22
3.8.6 Airlift Bioreactor 22
3.8.7 Water-Jacketed Bioreactor 23
3.9 Media 23
3.9.1 Role of Media 23
3.9.2 Types of Media 23
3.10 Sera 24
3.10.1 Sources of Sera 24
3.10.2 Sera Safety and Regulations 25
3.10.3 Shift to Serum Free Media 26
3.11 Reagents 26
3.11.1 Major Types of Biologic Reagents 26
3.11.2 Reagent Safety Issues 28

4 Cell Culture - Current and Future Trends 29
4.1 Cell Culture Market Forecast 29
4.2 Media Market Forecast 30
4.3 Sera Market Forecast 31
4.4 Reagents Market Forecast 32
4.5 Drivers and Restraints for Cell Culture Market 33
4.5.1 Drivers for Cell Culture Market 33
4.5.2 Restraints for Cell Culture Market 34

5 Cell Culture - Biopharmaceuticals an Important Part of Cell Culturing 35
5.1 Genetic Modifications 35
5.1.1 Cell Culture Life-Cycle Expressions 35
5.1.2 Biotechnological Product Development Using Cell Culture Method 37
5.1.3 Cell Banking and Seed Culture 38
5.1.4 Cell Systems 39
5.1.5 Advantages and Disadvantages of Cell Culture Techniques 41
5.2 Cell Lines and Banks 41
5.2.1 Manufacturing of Biopharmaceuticals using Cell Culture Techniques 41
5.2.2 Standard Methods for Cell Culture 42
5.2.3 Validation and Quality Maintenance 43
5.2.4 Essential Guidelines for Maintaining Sterilization Standards 43
5.3 Successful Treatments from Biopharmaceuticals is Increasing the Demand for Cell Culturing 44

6 Key Players in the Culture Media, Sera and Reagents Market 45
6.1 Cell Culture Suppliers' Market Share 45
6.1.1 Life Technologies Corporation 46
6.1.2 Sigma-Aldrich Corporation 47
6.1.3 Thermo Fisher Scientific Inc. 48
6.1.4 Affymetrix, Inc. 49
6.1.5 BD Biosciences 50
6.1.6 EMD Millipore 51
6.1.7 Advanced Biotechnologies, Inc. 52
6.1.8 Amresco 53
6.1.9 Analytical Biological Services Inc. 54
6.1.10 Athena Biotechnologies, Inc. 55
6.1.11 Biochrom AG 56
6.1.12 Bioreclamation, Inc. 57
6.1.13 Cell Essentials, Inc 58
6.1.14 CellGenix Technologie Transfer GmbH 59
6.1.15 Clontech Laboratories, Inc. 60
6.1.16 Gemini Bio-Products 61
6.1.17 Lonza BioSciences Singapore Pte Ltd 62
6.1.18 Mediatech, Inc. 63
6.1.19 MP Biomedicals, LLC 64
6.1.20 PAA Laboratories GmbH 65
6.1.21 Quality Biological, Inc. 66
6.1.22 R&D Systems, Inc. 67
6.1.23 SAFC Biosciences, Inc. 68
6.1.24 Selexis SA 69
6.1.25 SeraCare Life Sciences, Inc. 70
6.1.26 Sera Laboratories International Ltd. 71

7 Cell Culture - Appendix 72
7.1 Market Definitions 72
7.2 Abbreviations 72
7.3 Bibliography 73
7.4 Research Methodology 74
7.4.1 Coverage 74
7.4.2 Secondary Research 74
7.4.3 Primary Research 75
7.4.4 Expert Panel Validation 75
7.5 Contact Us 75
7.6 Disclaimer 75

List of Tables

Table 1: Cell Culture, Basal-Media Components, 2011 18
Table 2: Cell Culture, Examples and Applications of Specialty Media, 2011 24
Table 3: Cell Culture, Validation Test for Sera Approval, 2011 25
Table 4: Cell Culture, Global, Revenue ($bn), 2004-2011 29
Table 5: Cell Culture, Global, Revenue ($bn), 2011-2018 29
Table 6: Cell Culture, Media Market Revenues, Global ($m), 2004-2011 30
Table 7: Cell Culture, Media Market Revenues, Global ($m), 2011-2018 30
Table 8: Cell Culture, Sera Market Revenues, Global ($m), 2004-2011 31
Table 9: Cell Culture, Sera Market Revenues, Global ($m), 2011-2018 31
Table 10: Cell Culture, Reagent Market Revenues, Global ($bn), 2004-2011 32
Table 11: Cell Culture, Reagent Market Revenues, Global ($bn), 2011-2018 32
Table 12: Cell Culture, Manufacturing Models, 2011 35
Table 13: Cell Culture, Comparison of Therapeutic Protein Production across Different Systems, 2011 35

List of Figures

Figure 1: Cell Culture, Transgenic Model, Process Steps, 2011 12
Figure 2: Cell Culture, Applications of Stem Cell Research, 2011 14
Figure 3: Cell Culture, Stem Cell Research, Porter's Five Force Analysis, 2011 15
Figure 4: Cell Culture, Fermentation Cycle, 2011 16
Figure 5: Cell Culture, Batch and Fed-Batch Fermentation, 2011 17
Figure 6: Cell Culture, Upstream Processing in Biopharmaceuticals, Tray Bioreactor, 2011 20
Figure 7: Cell Culture, Upstream Processing in Biopharmaceuticals, Stirred Tank Bioreactor, 2011 21
Figure 8: Cell Culture, Global, Revenue ($bn), 2004-2018 29
Figure 9: Cell Culture, Media Market Revenues, Global ($m), 2004-2018 30
Figure 10: Cell Culture, Sera Market Revenues, Global ($m), 2004-2018 31
Figure 11: Cell Culture, Reagent Market Revenues, Global ($m), 2004-2018 32
Figure 12: Cell Culture, Market, Drivers and Restraints, 2011 33
Figure 13: Cell Culture, Cell Bank System, 2011 38
Figure 14: Cell Culture, Suppliers Market Share, Global, 2011 45
Figure 15: Cell Culture, Life Technologies Corporation, Business Overview, 2011 46
Figure 16: Cell Culture, Sigma-Aldrich Corporation, Business Overview, 2011 47
Figure 17: Cell Culture, Thermo Fisher Scientific Inc., Business Overview, 2011 48
Figure 18: Cell Culture, Affymetrix, Inc., Business Overview, 2011 49
Figure 19: Cell Culture, BD Biosciences, Business Overview, 2011 50
Figure 20: Cell Culture, EMD Millipore, Business Overview, 2011 51
Figure 21: Cell Culture, Advanced Biotechnologies, Inc., Business Overview, 2011 52
Figure 22: Cell Culture, Amresco Inc., Business Overview, 2011 53
Figure 23: Cell Culture, Analytical Biological Services Inc., Business Overview, 2011 54
Figure 24: Cell Culture, Athena Biotechnologies, Inc., Business Overview, 2011 55
Figure 25: Cell Culture, Biochrom AG, Business Overview, 2011 56
Figure 26: Cell Culture, Bioreclamation, Inc, Business Overview, 2011 57
Figure 27: Cell Culture, Cell Essentials, Inc., Business Overview, 2011 58
Figure 28: Cell Culture, CellGenix Technologie Transfer GmbH, Business Overview, 2011 59
Figure 29: Cell Culture, Clontech Laboratories, Inc., Business Overview, 2011 60
Figure 30: Cell Culture, Gemini Bio-Products, Business Overview, 2011 61
Figure 31: Cell Culture, Lonza BioScience Singapore Pte Ltd, Business Overview, 2011 62
Figure 32: Cell Culture, Mediatech, Inc., Business Overview, 2011 63
Figure 33: Cell Culture, MP Biomedicals, LLC, Business Overview, 2011 64
Figure 34: Cell Culture, PAA Laboratories GmbH, Business Overview, 2011 65
Figure 35: Cell Culture, Quality Biological, Inc., Business Overview, 2011 66
Figure 36: Cell Culture, R&D Systems, Inc., Business Overview, 2011 67
Figure 37: Cell Culture, SAFC Biosciences, Inc., Business Overview, 2011 68
Figure 38: Cell Culture, Selexis SA, Business Overview, 2011 69
Figure 39: Cell Culture, SeraCare Life Sciences, Business Overview, 2011 70
Figure 40: Cell Culture, Sera Laboratories International Ltd., Business Overview, 2011 71

  • The Prospective Market of Drug Eluting Stents
    Drug Eluting Stents are the recent development that’s are now being used frequently for curing narrowed coronary arteries. These stents help to keep the artery open and supply drugs at regular intervals preventing any further obstruction. The stents are usually small scaffolds of wire and are placed in the artery. This has been a welcome [...]
  • Anaesthesia Machine Industry is Flourishing due to an Extensive Customer Base with Therapeutic Needs
    The Anaesthesia Machine Industry comprises of the manufacturers and users of Anaesthesia Machines which are basically workstations or units that assist a person to administer Anaesthesia on the other. It includes plug & play Anaesthesia delivery units (ADUs). The industry also comprises of the various accessories like monitors and information systems and support services involved [...]
  • The Need for an Electric Cars Boosts The Lithium Sulfate Market
    Lithium is a highly demanded material. The popularity of this metal is primarily due to the characteristics of this metal and its compounds. Some of the characteristics of this material are that it has the highest electrochemical potential of all metals, a very high co-efficient of thermal expansion, acting as a viscosity modifier in melts, [...]
  • Tire Roller Industry
    Tire roller is one of the most popular equipment used in the construction industry. A tire roller offers multiple services from building highways, industrial sites, binder courses, wear courses and many more. Tire rollers come with different features like easy adjustment of tyres, flexible ballast, oscillating tires, etc. that facilitates in doing a particular work. [...]
  • The Adhesive Paper Industry Looking At a Long Term Bonding
    Adhesives are used extensively in the Paper Industry. They are primarily two kinds ie, the adhesive is either water based or hot melts. The kind of requirement determines the adhesive type in this industry. Adhesives have a wide arena of application. It is used as envelope gums, bookbinding adhesives, for lamination of paper, corrugated adhesives, [...]
  • The Oil Drilling Rig Industry
  • The Oil Drilling Rig Industry is characterized with a few typical work specific to this industry only. The work begins with the search for new oil basins or construction of wells. During this time the services of drilling contractors and …

  • HER2-Negative Breast Cancer’s Therapeutic Market
  • HER2-Negative Breast Cancer is the most common form of cancer occurring in women. The long term survival of patients diagnosed with HER2-Negative Breast Cancer depends solely on its early detection as till now there is no medicine that can cure …

  • The Market of Plate Heat Exchanger
  • Plate heat exchanger is not only very useful but its also easy to maintain, its compact design makes it more efficient, the product is highly cost-efficient and also the materials of this product are easily available. There are some limitations …

  • The Industry of Binding Machines
  • Binding of books and papers is one of the most important aspect of buying and selling books and thus the demand of binding machines. There are different kinds of binding machines available in the market. The binding type determines the …

  • The Boom In Women Infertility Market
  • Infertility is an abnormality in the regular functioning of the human reproductive system. Anyone of male or female might be suffering from this issue. Infertility in woman is caused by either a genetical factor or factors such as aging or …

  • Global Bioinformatics Market 2015-2019
    Published: 20-May-2015        Price: US $2500 Onwards        Pages: 76
    Bioinformatics is a field of science that includes computational analysis of biological data, which consists of information stored in DNA form and protein sequences in various biological databases. Biology, information technology, and computer science merge into single discipline in bioinformatics. This field is deep rooted in molecular biology and surrounds subject areas from structural biology, genomics to gene expression studies. Bioinformatics is commonly used for identifying SNPs and candid......
  • Genotyping Market by Technology (Polymerase Chain Reaction, Sequencing, Microarray, Electrophoresis, MALDI_TOF), Application (Pharmacogenomics, Diagnostic Research, Animal Genetics, Agricultural Biotechnology) & by Products – Global Forecast to 2020
    Published: 15-May-2015        Price: US $4650 Onwards        Pages: 200
    Genotyping is used to study genetic variation in the genotypes of living organisms, including humans, animals, plants, and microorganisms. The genotyping market is mainly driven by technological advancements, increasing incidence of genetic diseases and awareness on personalized medicine,decreasing prices of DNA sequencing, growing importance of SNP genotyping in drug development, and the growing demand for genotyping of animal and plant livestock. However, ambiguity inthe reimbursement for thes......
  • Bioburden Testing Market by Product [Instrument (PCR, Microscopes), & Consumables (Kit, Reagent)], Test (Aerobic, Anaerobic, Fungi, Spore), Application (Raw Material, In-process) & End User (Pharmaceutical, Biotechnology, CMO) – Forecast to 2019
    Published: 14-May-2015        Price: US $4650 Onwards        Pages: 180
    The bioburden testing market is expected to reach $565.6 million by 2019 from $354.4 million in 2014, at a CAGR of 9.8% from 2014 to 2019. This market is segmented on the basis of products, test types, applications, end users, and regions. On the basis of end users, the market is segmented into pharmaceutical and biotechnology companies, medical device manufacturers, contract manufacturing organizations (CMOs), manufacturers of food & beverage and agricultural products, and microbial testing......
  • Live Cell Imaging Market by Product (Equipment, Consumables, Software), Technology (Fluorescence Recovery after Photobleaching, High-Content Screening) & by Application (Cell Biology, Stem Cells, Drug Discovery) – Analysis & Global Forecast to 2019
    Published: 12-May-2015        Price: US $4650 Onwards        Pages: 219
    Over the years, the live cell imaging market has witnessed various technological advancements in order to study the functions of live cells that meet the needs of academic and government institutes, pharmaceutical and biotechnology industries, contract research organizations, and diagnostics laboratories. These advancements have led to the development of various technologies used for live cell imaging. In 2014, the equipment segment accounted for the largest share of the live cell imaging mar......
  • Mycoplasma Testing Market by Products (Instruments, Kits & Reagents, Services), Application (Cell Line, Virus, End of Production Cells), Technology (PCR, ELISA, Direct Assay), End User (Cell Banks, Pharmaceutical Companies) – Global Forecast to 2019
    Published: 11-May-2015        Price: US $4650 Onwards        Pages: 175
    The global mycoplasma testing market is expected to reach $613.49 million by 2019 from $340.29 million in 2014, growing at a CAGR of 12.51% between 2014 and 2019. The mycoplasma testing product segments included in this report are instruments, kits & reagents, and services. The kits & reagents segment is further divided on the basis of type into stains, elimination kits, PCR assays, nucleic acid detection kits, standards & controls and other kits & reagents.The technology segment......
  • Global β-Amylase Industry Report 2015
    Published: 8-May-2015        Price: US $2800 Onwards        Pages: 188
    This is a professional and in-depth study on the current state of the β-Amylase industry. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The β-Amylase market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. Development policies and plans are also discussed and manufacturing processes and cost structure......
  • Global β-Glucanase Industry Report 2015
    Published: 8-May-2015        Price: US $2800 Onwards        Pages: 165
    This is a professional and in-depth study on the current state of the β-Glucanase industry. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The β-Glucanase market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. Development policies and plans are also discussed and manufacturing processes and cost struc......
  • Cell Counting Market by Product [Instruments (Spectrophotometer, Cell Counter, Hemocytometer, Flow Cytometer, Hematology Analyzer) Consumables (Reagent, Assay Kits, Microplate)], End User (Pharmaceutical, Hospital, Research) – Global Forecast to 2020
    Published: 7-May-2015        Price: US $4650 Onwards        Pages: 150
    Over the past five years, the cell counting market has witnessed tremendous growth primarily due to high prevalence of AIDS and cancer across the globe and increasing stem cell research expenditure. In this report, the global cell counting market is segmented on the basis of products, end users, and by region. On the basis of products, the cell counting market is categorized into spectrophotometers, flow cytometers, hematology analyzers, and cell counters. The spectrophotometers segment is fu......
  • Genome Editing / Genome Engineering Market by Application (Cell Line Engineering, Animal & Plant Genetic Engineering), Technology (CRISPR, Antisense, TALEN, Zinc Finger Nuclease) & End User (Biotechnology & Pharmaceutical, CRO) – Global Forecast to 2019
    Published: 7-May-2015        Price: US $4650 Onwards        Pages: 170
    In this report,the genome editing market is segmentedon thebasis of applications, technologies, end users, and regions. The application segments included in this report are cell line engineering, animal genetic engineering, plant genetic engineering, and other applications. The genome editing market, by technology, is categorized into CRISPR, TALEN, ZNF, antisense technology, and other technologies. The end-user segment includes biotechnology and pharmaceutical companies, academic and government......
  • SERVICES
    Value for Money
    We believe in "optimum utilization of available budget and resources". While servicing our clients' (your) market research requirements, we keep the same approach in focus to help you get the best value for your $$s.
    Ever Growing Inventory
    Ranging from the smallest feasible / required data (datasheets, data facts, SWOT analysis, company profiles, etc) to full research reports that help you make decisions, our inventory is updated almost on a daily basis with the latest industry reports from domain experts that track more than 5000 niche sectors.
    One Stop Solution
    Need a custom research report on medical devices market? Require all available business intelligence on 3D printing industry? Exploring F&B sector of a particular country/region? RnRMarketResearch.com is your one-stop-solution to all market intelligence needs. We not only offer custom research and consulting services, we also "bundle" reports to meet your needs and help you fetch the data analysis you require for your business.
    Dedicated Client Engagement
    Not limited to only "finding" relevant reports for you, our client engagement team dedicates its efforts to understand your "business need" and accordingly maps available research data to help you move forward. Call "your" client engagement executive any time of your day and get your questions answered in order to make the correct business decision.
    Saving Time and Efforts
    Simply share your research requirement details with us and let us do all the hard work to find required intelligence for you. When you add up our "one stop solution" and "dedicated client engagement" services mentioned above, you obviously know the time and effort saving you do by working with us.
    Payment Flexibility
    Working with Fortune 500 organizations, we understand the importance of being flexible for payments. Share your payment terms with us and we will surely match up to them to ensure you get access to required business intelligence data without having to wait for the payment to be done.
    Post-Purchase Research Support
    Have questions after reading a report / datasheet bought through us? Not sure about the methodology used for data available in the research? Talk to us / Share your questions with us and if required, we will connect you with the analyst(s)/author(s) of the report(s) and ensure you get satisfactory answers for the same. Need more data / analysis / report(s) on the topic of your research/project? The RnRMarketResearch.com team is here for you 24X7 to support you with your post-purchase requirements. Subscription Offers & Packages (Get in touch with us for more details - [email protected] / +1 888 391 5441 )
    • Ad Hoc
    • Pay - as - you - go / Bucket Subscriptions
    • Fixed Cost for #of reports
    • Customize / Personalize as per your needs