Avastin (Colorectal Cancer) - Forecast and Market Analysis to 2023

Publisher Name :
Date: 28-Nov-2014
No. of pages: 57

GlobalData has released its new PharmaPoint Drug Evaluation report, "Avastin (Colorectal Cancer) Forecast and Market Analysis to 2023". Colorectal cancer (CRC) is the second leading cause of mortality among cancer patients in the world and is the third most diagnosed cancer globally, and thus represents a huge burden on healthcare systems. This report focuses on the current treatment landscape, unmet needs, current pipeline, and commercial opportunities in the colorectal cancer market, with coverage of multiple settings of the disease including neoadjuvant/adjuvant, first-, second-, third-line KRAS wild-type and mutation-positive, and fourth-line metastatic. In terms of targeted treatments, the metastatic CRC treatment landscape is mature, including the branded treatments Avastin (bevacizumab), Avastin (cetuximab), and Vectibix (panitumumab), treatments that have extended the survival of metastatic patients compared to chemotherapy-only regimens. However, high unmet needs remain for the extension of survival of metastatic patients, and particularly those with KRAS mutation-positive disease, for whom the epidermal growth factor receptor (EGFR) inhibitors Avastin and Vectibix are not recommended.

Avastin was the first agent of a new class of drugs that targeted the angiogenesis pathway. The anti-angiogenic agent is a humanized monoclonal IgG1 that binds to vascular endothelial growth factor-A (VEGF-A), preventing the ligand from binding to the VEGF receptor. Inhibition of the VEGF pathway prevents endothelial cells from proliferating and forming the new bloods vessels that are required for the tumor to grow. The drug delivered as a monotherapy is not curative, and must be co-administered with a chemotherapy regimen.


  • Overview of Colorectal Cancer, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.

  • Detailed information on Avastin including product description, safety and efficacy profiles as well as a SWOT analysis.

  • Sales forecast for Avastin for the top eight countries from 2013 to 2023.

  • Sales information covered for the US, France, Germany, Italy, Spain, the UK, Japan and China.

Reasons to buy

  • Understand and capitalize by identifying products that are most likely to ensure a robust return

  • Stay ahead of the competition by understanding the changing competitive landscape for Colorectal Cancer

  • Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential

  • Make more informed business decisions from insightful and in-depth analysis of Avastin performance

  • Obtain sales forecast for Avastin from 2013-2023 in top eight countries (the US, France, Germany, Italy, Spain, the UK, Japan and China)

Avastin (Colorectal Cancer) - Forecast and Market Analysis to 2023

Table of Contents

1 Table of Contents 5
1.1 List of Tables 7

2 Introduction 8
2.1 Catalyst 8
2.2 Related Reports 9
2.3 Upcoming Related Reports 10

3 Disease Overview 11
3.1 Etiology and Pathophysiology 11
3.1.1 Etiology 11
3.1.2 Pathophysiology 13
3.2 Clinical Staging 14
3.3 Symptoms 16

4 Disease Management 17
4.1 Diagnosis and Treatment Overview 17
4.1.1 Screening and Diagnosis 17
4.1.2 Treatment Guidelines and Leading Prescribed Drugs 20
4.1.3 Clinical Practice 24

5 Competitive Assessment 31
5.1 Overview 31

6 Avastin (Bevacizumab) 33
6.1 Overview 33
6.2 Efficacy 35
6.3 Safety 35
6.4 SWOT Analysis 37
6.5 Forecast 37

7 Appendix 39
7.1 Bibliography 39
7.2 Abbreviations 45
7.3 Methodology 48
7.4 Forecasting Methodology 48
7.4.1 Diagnosed Colorectal Cancer Patients 48
7.4.2 Percent Drug-Treated Patients 49
7.4.3 General Pricing Assumptions 49
7.4.4 Average Body Weight and Surface Area Across the 8MM 50
7.4.5 Individual Drug Assumptions 50
7.4.6 Generic Erosion 51
7.5 Primary Research - KOLs Interviewed for this Report 52
7.6 Primary Research - Prescriber Survey 53
7.7 About the Authors 54
7.7.1 Analyst 54
7.7.2 Global Head of Healthcare 55
7.8 About GlobalData 56
7.9 Disclaimer 56

List of Tables

Table 1: TNM and Staging Classification System for CRC 15
Table 2: Symptoms of Colorectal Cancer 16
Table 3: Treatment Guidelines for CRC 21
Table 4: Most-Prescribed Neoadjuvant/Adjuvant Regimens for Early-Stage CRC in the Global Markets, 2013 22
Table 5: Most Prescribed Targeted Therapies for Metastatic CRC by Segment in the Global Markets, 2013 23
Table 6: Leading Treatments for CRC, 2014 32
Table 7: Product Profile ? Avastin 34
Table 8: Avastin SWOT Analysis, 2014 37
Table 9: Global Sales Forecast ($m) for Avastin, 2013-2023 38
Table 10: Average Body Weight and Surface Area Across the 8MM 50
Table 11: High-Prescribing Physicians (non-KOLs) Surveyed, By Country 53

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