Automated Patch Clamping Trends 2014

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Date: 17-Apr-2014
No. of pages: 54
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Executive Summary

  • This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on ion channel drug screening using automated patch clamping (APC) technology carried out in March 2014.
  • The study was initiated by HTStec as part of its ongoing tracking of life science marketplaces. The questionnaire was compiled to meet the needs and interests of ephys/APC vendor community.
  • The objective of this global benchmarking study was to comprehensively document current practices, preferences and metrics in ion channel drug screening using APC technology. It also seeks to chart the emergence of new 384-well APC systems, what determines APC consumable budgets, and most prevents end-users making greater use of APC consumables. In addition, a secondary focus was to understand respondents’ interests and requirements in using a new APC technology for the analysis of adherent cellular 2D networks.
  • Equal emphasis was given to soliciting opinion from Pharma, Other Screening Labs and Academic Research segments in North America, Europe and Japan.
  • The survey looked at the following aspects of ion channel screening using APC technology, as practiced to date (2014) and in some cases as predicted for the future (2016): ion channels classes of greatest interest; ion channels that have proved most difficult to run as primary screens; number of ion channel programs investigated; primary drivers for initiating a new ion channel programs; areas of drug discovery applying APC technologies; typical size of the compound library in drug discovery areas using an APC platform; number of APC patch wells expected to processed per year; proportion of APC assays using different cell types; current access to APC ion channel platforms; preferred vendor’s APC systems for different criteria; likelihood of purchasing a new APC platform over the next few years; factors that most influence a decision to purchase a particular APC platform; APC consumables budget for ion channel screening and how they are determined; what factors most prevent making greater use of APC consumables today; whether the recent introduction of new 384-well APC screening platforms will affect screening activities; prohibitive and stimulative 384-well APC consumable pricepoints; and awareness of the FDA CIPA working group and its potential impact on safety assays undertaken. With respect to a new APC system for adherent 2D cellular networks the following were investigated: technologies already used to obtain information on cell-cell communication within cellular 2D networks; what respondents most want to analyze with the system; applications most suited to the system; cell types most likely to be used with the system; main advantages of the system; impact of the potential disadvantages of the system; features essential for the adoption and exploitation of the system; optimal patch combinations; usefulness of the potential throughput likely to be achieved with the system; preferred routes to access and fit to existing workflow of the system; reasonable price to pay for the APC system; likelihood of future purchasing of the system; reasonable APC consumable pricing for the system; and interest to receive more information/testing of the system.
  • The survey questionnaire consisted of 32 mainly multi-choice questions. In addition, there were 6 questions related solely to survey demographics.
  • The survey collected 88 validated responses, of these 63% provided comprehensive input.
  • Survey responses were geographically split: 34% North America; 31% Europe; 30% Japan; 2% China; 2% Rest of World; and 1% India.
  • Survey respondents were drawn from persons or groups actively involved in ion channel screening, selectivity profiling and safety assessment against ion channel liabilities using APC systems.
  • Respondents represented: 20 Medium-Small Pharma; 17 University/ Research Institute/Government Labs/ Not-for-Profit; 16 Large Pharma; 15 Biotech Company; 9 Contract Research Organisation; 6 Biopharma; 2 Academic Screening Center; 1 Agrochemical/Agri-Biotech Company; 1 Tobacco Company and 1 Other.
  • Most survey respondents had a senior job role or position which was in descending order: 20 research scientists/associates; 20 senior scientists/researchers; 12 principal investigators; 9 section/group leaders; 5 post-docs; 5 department heads; 5 directors; 4 lab managers; 4 professors/assistant professors; 2 vice presidents; and 2 others.
  • Survey results were expressed as an average of all survey respondents. In addition, where appropriate the data was reanalyzed after sub-division into the following 6 survey groups: 1) Pharma; 2) Other Screening Labs; 3) Academic Research; 4) Europe; 5) North America; and 6) Japan.
  • The ion channel research activity most undertaken by respondents was secondary screening.
  • The class of ion channels of most interest was voltage-gated potassium channels. The class of ion channels most experienced difficulty running as primary screens was voltage-gated calcium channels.
  • A median of 3 ion channel programs were under investigation in respondent’s organisation.
  • The primary driver for initiating a new ion channel program was the disease focus of the company.
  • APC technologies were most used today for assay development and hits-to-leads (lead optimization).
  • The median compound library size tested using APC was: 1K-5K for primary screening/HTS; <1K for all hit-to-lead follow-up; and <1K for early non-compliant hERG liability testing.
  • The median number of APC wells processed/year was: 5K-10K for primary screening/HTS; 1K-5K for all hit-to-lead follow-up; and 1K-5K for early non-compliant hERG liability testing.
  • The cell type they most used for APC assays today was recombinant cell lines.
  • The most common APC system available for use in respondents’ labs was the Sophion QPatch 8, 16 or HT.
  • From current prevalence of APC instruments Molecular Devices & Sophion have the greatest vendor share.
  • Of a list of relevant criteria Molecular Devices was the preferred vendor’s APC system with respect cost per consumable, cost per data point and throughput. Sophion was the preferred vendor’s APC system with respect to the 11 other important criteria rated.
  • The median likelihood respondents will purchase a new APC platform over the next few years (by end of 2016) was low (<10% purchasing probability).
  • APC platforms currently most appealing for purchasing were Sophion Qube & Nanion Syncropatch 384PE.
  • The quality of the results was the factor which would most influence a decision to purchase a particular brand/model of APC platform.
  • The median annual APC consumable budget was $50K-$100K/year today.
  • Several bottom-up models were developed around the respondent’s feedback to calculate the global APC markets. In 2014 these were estimated to be around $140M for APC consumables and $38M for new APC platforms. Segmentation & some CAGR estimates are in the full report.
  • The APC consumable budget for ion channel testing of most respondents was not fixed i.e. it can be adjusted to reflect cost changes per data point.
  • The factors that most prevent greater use of APC consumables today were the high cost of APC consumables and lack of ion channel projects.
  • The most predicted effect of the introduction of new 384-well APC screening platforms was to increase the number of data points screened, but with a similar consumable budget.
  • For new 384-well APC screening platforms the median prohibitive pricepoint (i.e. limits use to certain applications & inhibits adoption) was $1.00 per APC data point and $350-$450 per 384-well patch plate.
  • The majority were aware of the FDA CIPA working group where the cardiac risk panel was questioned.
  • The most investigated technology to obtain information on cell-cell communication within a 2D cellular network was manual patch clamp.
  • A new APC system in development for the analysis whole-cell and cell-attached-measurements of individual cells (e.g. neural or cardiac) in an adherent cellular 2D network was presented. The following feedback was obtained with respect to the technology in general or to the proposed academic APC system: 1) analyzing more than one adherent cell from a network in parallel was rated where greatest interest resides; 2) analyzing neuronal networks in general was rated the most suitable application; 3) primary neurons and recombinant cell lines were the cell types most would like to investigate; 4) allows for analysis of cell-cell communication was ranked as the greatest advantage; 5) the need to invest in a new APC system to measure cellular 2D networks was rated the biggest limitation; 6) extracellular perfusion of the whole well was selected as the most essential feature for adopting and exploiting the system; 7) the most wanted patch combination was 100-150 μm patch-to-patch distance, 2 patch sites per chip; 8) the throughput detailed (10 networks per day) was moderately useful in all drug discovery areas, apart from primary screening/HTS; 9) the preferred route to access was via a fee-for-service provider as an addition to current patch-clamp techniques; 10) the median reasonable price was $100K per system; 11) the median probability of purchasing when it becomes available was overall low (<10%), but medium (10-50%) in academic labs; 12) the median reasonable price for an APC consumable was $100-$200 per single chip; and 13) 24 labs want to receive more information and 17 labs want to test the academic APC system. Feedback on the proposed pharmaceutical APC system is given the full report.
  • The full report provides the data, details of the breakdown of the responses for each question, its segmentation and the estimates for the future (2016). It also highlights some interesting differences between the survey groups.

Automated Patch Clamping Trends 2014 published by HTStec Ltd in 17 April 2014. This report consists of 54 Pages and the price starts from US $ 2500.

Automated Patch Clamping Trends 2014

Table of Contents

Executive Summary 2
Survey Methodology 5
Respondent’s Organisation And Response To The Survey 6
Respondent’s Company Or Organisational Origin 7 Respondent’s Geographic Origin 8
Respondent’s Job Role 9
Ion Channel Research Activities Undertaken By Respondents 10
Classes of Ion Channels of Most Interest to Respondents 11
Classes of Ion Channels Most Difficult To Screen 12
Number Of Ion Channel Drug Discovery Programs Under Investigation (1) 13
Number Of Ion Channel Drug Discovery Programs Under Investigation (2) 14
Primary Drivers For Initiating A New Ion Channel Program 15
Use Of APC Technologies In Different Drug Discovery Areas 16
Compound Library Size Tested Using An APC Platform 17
Number Of APC Well Processed Per Year Using An APC Platform 18
Summary of Survey Findings (1) 19
Proportion Of Different Cell Types Used In APC Assays 21
APC Platforms Respondents Currently Have Access To 22
Preferred Vendor’s APC System For Various Criteria 23
Likelihood Will Purchase A New APC Platform Over The Next Few Years 24
Number Of Units Of A New APC Platform Respondents Might Purchase 25
APC Platforms Most Appealing For Future Purchasing 26
Factors Which Would Most Influence Purchasing Of APC Platform 27
APC Consumables Budget 28
APC Market Estimates (1) 29
APC Market Estimates (2) 30
How APC Consumable Budget For Ion Channel Testing Is Determined 31
Factors Preventing Greater Use Of APC Consumables 32
How New 384 APC Platforms May Affect Screening Activities 33
APC Consumable Pricepoints For New 384-Well APC Screening Platforms 34
Awareness of FDA CIPA Working Group And Impact On Safety Assays 35
Summary of Survey Findings (2) 36
New APC System for 2D Cellular Networks (Technology Description) 38
Technologies Investigated To Obtain Information On Cell-Cell Communication With 2D Cellular Networks (1) 39 Technologies Investigated To Obtain Information On Cell-Cell Communication With 2D Cellular Networks (2) 40 What Respondents Most Want To Analyze With A New APC System For 2D Cellular Networks 41
Applications Most Suited To An APC System For 2D Cellular Networks 42
Preferred Cell Types For An APC Analysis System For 2D Cellular Networks 43
Main Advantages Of An APC System For 2D Cellular Networks 44
Potential Disadvantages Of An APC System For Adherent Cellular 2D Networks 45
Features Needed In A New APC System For Analysis Of Cellular 2D Networks 46
Patch Combinations Most Optimal For Respondent’s Research 47
Throughput Needed For Analysis 2D Cellular Networks 48
Preferred Route To Access A New APC System For Cellular 2D Networks 49
Reasonable Price To Pay For A New APC System For 2D Cellular Networks Networks 50
Likelihood Of Purchasing A New APC System For Cellular 2D Networks 51
Reasonable Price To Pay For APC Consumables For 2D Cellular Networks 52
Respondents Interested In More Info Or Testing The New APC System For 2D Cellular Networks 53
Summary of Survey Findings (3) 54

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