Automated Patch Clamping Trends 2014

Publisher Name :
Date: 17-Apr-2014
No. of pages: 54

Executive Summary

  • This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on ion channel drug screening using automated patch clamping (APC) technology carried out in March 2014.
  • The study was initiated by HTStec as part of its ongoing tracking of life science marketplaces. The questionnaire was compiled to meet the needs and interests of ephys/APC vendor community.
  • The objective of this global benchmarking study was to comprehensively document current practices, preferences and metrics in ion channel drug screening using APC technology. It also seeks to chart the emergence of new 384-well APC systems, what determines APC consumable budgets, and most prevents end-users making greater use of APC consumables. In addition, a secondary focus was to understand respondents’ interests and requirements in using a new APC technology for the analysis of adherent cellular 2D networks.
  • Equal emphasis was given to soliciting opinion from Pharma, Other Screening Labs and Academic Research segments in North America, Europe and Japan.
  • The survey looked at the following aspects of ion channel screening using APC technology, as practiced to date (2014) and in some cases as predicted for the future (2016): ion channels classes of greatest interest; ion channels that have proved most difficult to run as primary screens; number of ion channel programs investigated; primary drivers for initiating a new ion channel programs; areas of drug discovery applying APC technologies; typical size of the compound library in drug discovery areas using an APC platform; number of APC patch wells expected to processed per year; proportion of APC assays using different cell types; current access to APC ion channel platforms; preferred vendor’s APC systems for different criteria; likelihood of purchasing a new APC platform over the next few years; factors that most influence a decision to purchase a particular APC platform; APC consumables budget for ion channel screening and how they are determined; what factors most prevent making greater use of APC consumables today; whether the recent introduction of new 384-well APC screening platforms will affect screening activities; prohibitive and stimulative 384-well APC consumable pricepoints; and awareness of the FDA CIPA working group and its potential impact on safety assays undertaken. With respect to a new APC system for adherent 2D cellular networks the following were investigated: technologies already used to obtain information on cell-cell communication within cellular 2D networks; what respondents most want to analyze with the system; applications most suited to the system; cell types most likely to be used with the system; main advantages of the system; impact of the potential disadvantages of the system; features essential for the adoption and exploitation of the system; optimal patch combinations; usefulness of the potential throughput likely to be achieved with the system; preferred routes to access and fit to existing workflow of the system; reasonable price to pay for the APC system; likelihood of future purchasing of the system; reasonable APC consumable pricing for the system; and interest to receive more information/testing of the system.
  • The survey questionnaire consisted of 32 mainly multi-choice questions. In addition, there were 6 questions related solely to survey demographics.
  • The survey collected 88 validated responses, of these 63% provided comprehensive input.
  • Survey responses were geographically split: 34% North America; 31% Europe; 30% Japan; 2% China; 2% Rest of World; and 1% India.
  • Survey respondents were drawn from persons or groups actively involved in ion channel screening, selectivity profiling and safety assessment against ion channel liabilities using APC systems.
  • Respondents represented: 20 Medium-Small Pharma; 17 University/ Research Institute/Government Labs/ Not-for-Profit; 16 Large Pharma; 15 Biotech Company; 9 Contract Research Organisation; 6 Biopharma; 2 Academic Screening Center; 1 Agrochemical/Agri-Biotech Company; 1 Tobacco Company and 1 Other.
  • Most survey respondents had a senior job role or position which was in descending order: 20 research scientists/associates; 20 senior scientists/researchers; 12 principal investigators; 9 section/group leaders; 5 post-docs; 5 department heads; 5 directors; 4 lab managers; 4 professors/assistant professors; 2 vice presidents; and 2 others.
  • Survey results were expressed as an average of all survey respondents. In addition, where appropriate the data was reanalyzed after sub-division into the following 6 survey groups: 1) Pharma; 2) Other Screening Labs; 3) Academic Research; 4) Europe; 5) North America; and 6) Japan.
  • The ion channel research activity most undertaken by respondents was secondary screening.
  • The class of ion channels of most interest was voltage-gated potassium channels. The class of ion channels most experienced difficulty running as primary screens was voltage-gated calcium channels.
  • A median of 3 ion channel programs were under investigation in respondent’s organisation.
  • The primary driver for initiating a new ion channel program was the disease focus of the company.
  • APC technologies were most used today for assay development and hits-to-leads (lead optimization).
  • The median compound library size tested using APC was: 1K-5K for primary screening/HTS; <1K for all hit-to-lead follow-up; and <1K for early non-compliant hERG liability testing.
  • The median number of APC wells processed/year was: 5K-10K for primary screening/HTS; 1K-5K for all hit-to-lead follow-up; and 1K-5K for early non-compliant hERG liability testing.
  • The cell type they most used for APC assays today was recombinant cell lines.
  • The most common APC system available for use in respondents’ labs was the Sophion QPatch 8, 16 or HT.
  • From current prevalence of APC instruments Molecular Devices & Sophion have the greatest vendor share.
  • Of a list of relevant criteria Molecular Devices was the preferred vendor’s APC system with respect cost per consumable, cost per data point and throughput. Sophion was the preferred vendor’s APC system with respect to the 11 other important criteria rated.
  • The median likelihood respondents will purchase a new APC platform over the next few years (by end of 2016) was low (<10% purchasing probability).
  • APC platforms currently most appealing for purchasing were Sophion Qube & Nanion Syncropatch 384PE.
  • The quality of the results was the factor which would most influence a decision to purchase a particular brand/model of APC platform.
  • The median annual APC consumable budget was $50K-$100K/year today.
  • Several bottom-up models were developed around the respondent’s feedback to calculate the global APC markets. In 2014 these were estimated to be around $140M for APC consumables and $38M for new APC platforms. Segmentation & some CAGR estimates are in the full report.
  • The APC consumable budget for ion channel testing of most respondents was not fixed i.e. it can be adjusted to reflect cost changes per data point.
  • The factors that most prevent greater use of APC consumables today were the high cost of APC consumables and lack of ion channel projects.
  • The most predicted effect of the introduction of new 384-well APC screening platforms was to increase the number of data points screened, but with a similar consumable budget.
  • For new 384-well APC screening platforms the median prohibitive pricepoint (i.e. limits use to certain applications & inhibits adoption) was $1.00 per APC data point and $350-$450 per 384-well patch plate.
  • The majority were aware of the FDA CIPA working group where the cardiac risk panel was questioned.
  • The most investigated technology to obtain information on cell-cell communication within a 2D cellular network was manual patch clamp.
  • A new APC system in development for the analysis whole-cell and cell-attached-measurements of individual cells (e.g. neural or cardiac) in an adherent cellular 2D network was presented. The following feedback was obtained with respect to the technology in general or to the proposed academic APC system: 1) analyzing more than one adherent cell from a network in parallel was rated where greatest interest resides; 2) analyzing neuronal networks in general was rated the most suitable application; 3) primary neurons and recombinant cell lines were the cell types most would like to investigate; 4) allows for analysis of cell-cell communication was ranked as the greatest advantage; 5) the need to invest in a new APC system to measure cellular 2D networks was rated the biggest limitation; 6) extracellular perfusion of the whole well was selected as the most essential feature for adopting and exploiting the system; 7) the most wanted patch combination was 100-150 μm patch-to-patch distance, 2 patch sites per chip; 8) the throughput detailed (10 networks per day) was moderately useful in all drug discovery areas, apart from primary screening/HTS; 9) the preferred route to access was via a fee-for-service provider as an addition to current patch-clamp techniques; 10) the median reasonable price was $100K per system; 11) the median probability of purchasing when it becomes available was overall low (<10%), but medium (10-50%) in academic labs; 12) the median reasonable price for an APC consumable was $100-$200 per single chip; and 13) 24 labs want to receive more information and 17 labs want to test the academic APC system. Feedback on the proposed pharmaceutical APC system is given the full report.
  • The full report provides the data, details of the breakdown of the responses for each question, its segmentation and the estimates for the future (2016). It also highlights some interesting differences between the survey groups.

Automated Patch Clamping Trends 2014 published by HTStec Ltd in 17 April 2014. This report consists of 54 Pages and the price starts from US $ 2500.

Automated Patch Clamping Trends 2014

Table of Contents

Executive Summary 2
Survey Methodology 5
Respondent’s Organisation And Response To The Survey 6
Respondent’s Company Or Organisational Origin 7 Respondent’s Geographic Origin 8
Respondent’s Job Role 9
Ion Channel Research Activities Undertaken By Respondents 10
Classes of Ion Channels of Most Interest to Respondents 11
Classes of Ion Channels Most Difficult To Screen 12
Number Of Ion Channel Drug Discovery Programs Under Investigation (1) 13
Number Of Ion Channel Drug Discovery Programs Under Investigation (2) 14
Primary Drivers For Initiating A New Ion Channel Program 15
Use Of APC Technologies In Different Drug Discovery Areas 16
Compound Library Size Tested Using An APC Platform 17
Number Of APC Well Processed Per Year Using An APC Platform 18
Summary of Survey Findings (1) 19
Proportion Of Different Cell Types Used In APC Assays 21
APC Platforms Respondents Currently Have Access To 22
Preferred Vendor’s APC System For Various Criteria 23
Likelihood Will Purchase A New APC Platform Over The Next Few Years 24
Number Of Units Of A New APC Platform Respondents Might Purchase 25
APC Platforms Most Appealing For Future Purchasing 26
Factors Which Would Most Influence Purchasing Of APC Platform 27
APC Consumables Budget 28
APC Market Estimates (1) 29
APC Market Estimates (2) 30
How APC Consumable Budget For Ion Channel Testing Is Determined 31
Factors Preventing Greater Use Of APC Consumables 32
How New 384 APC Platforms May Affect Screening Activities 33
APC Consumable Pricepoints For New 384-Well APC Screening Platforms 34
Awareness of FDA CIPA Working Group And Impact On Safety Assays 35
Summary of Survey Findings (2) 36
New APC System for 2D Cellular Networks (Technology Description) 38
Technologies Investigated To Obtain Information On Cell-Cell Communication With 2D Cellular Networks (1) 39 Technologies Investigated To Obtain Information On Cell-Cell Communication With 2D Cellular Networks (2) 40 What Respondents Most Want To Analyze With A New APC System For 2D Cellular Networks 41
Applications Most Suited To An APC System For 2D Cellular Networks 42
Preferred Cell Types For An APC Analysis System For 2D Cellular Networks 43
Main Advantages Of An APC System For 2D Cellular Networks 44
Potential Disadvantages Of An APC System For Adherent Cellular 2D Networks 45
Features Needed In A New APC System For Analysis Of Cellular 2D Networks 46
Patch Combinations Most Optimal For Respondent’s Research 47
Throughput Needed For Analysis 2D Cellular Networks 48
Preferred Route To Access A New APC System For Cellular 2D Networks 49
Reasonable Price To Pay For A New APC System For 2D Cellular Networks Networks 50
Likelihood Of Purchasing A New APC System For Cellular 2D Networks 51
Reasonable Price To Pay For APC Consumables For 2D Cellular Networks 52
Respondents Interested In More Info Or Testing The New APC System For 2D Cellular Networks 53
Summary of Survey Findings (3) 54

  • Challenges in the Tourism Industry in Thailand
    Thailand has always been a popular tourist destination and tourism provides a major boost to the country’s economy. Bangkok, Hua Hin, Krabi, Samui, Phuket and Cha Am are some of the most attractive tourist destinations in the country. In 2012, Thailand had a very high number of arrivals. Even the number of Thai citizens who [...]
  • Future of the US Consumer Electronics Market
    The market for consumer electronics has been growing steadily. Some of the factors that are contributing to the growth in the market are technological advancement, rise in disposable income and increasing demand for new products. During 2012, consumer electronics market in the US demonstrated positive expansion, although the growth rate slowed down considerably following the [...]
  • Overview of the Global Retail Market
    The global retail industry continued to grow despite the difficult economic conditions in the world. In the fiscal year of 2011, sales-weighted, currency-adjusted revenue rose by 5.1% to $4.271 trillion for the world’s top 250 retailers. According to GRDI (Global Retail Development Index), in 2013 Brazil occupied the top spot in retail development. Chile and [...]
  • Bright Future Predicted for the Tourism Industry in Singapore
    Travel and tourism industry in Singapore has been growing at a steady rate and is considered to be a major contributor to the economic growth of the country. In 2012, Singapore’s IVA (International Visitors Arrivals) reached a record high of 14.5 million, with a growth rate of 10.1% year-on-year. In recent years, inbound travel to [...]
  • Potential of Staffing Market in United States
    The staffing industry places individuals into contract, temporary and permanent positions in firms around the world. Major staffing markets include France, Spain, Italy and Japan as well as many emerging markets. Temporary staffing around the world has been growing, but in US temporary market has been flat since 2006. The majority of staffing revenue majorly [...]
  • Graft-Versus-Host Disease (GVHD) Treatment Market worth $407 million by 2018
  • The graft-versus-host disease (GVHD) treatment market value will increase from $297 million in 2013 to $407 million by 2018, at a Compound Annual Growth Rate (CAGR) of 6.59%, according to research and consulting firm GlobalData. The company’s latest report* states …

  • Poland Pharmaceutical Industry Growing at 8.3% CAGR to 2020
  • Factors such as the growing elderly population, increasing availability of affordable medicines, and transparent regulatory guidelines will provide the necessary impetus for the growth of the Polish pharmaceutical market, but a decrease in mark-up prices and the country’s stringent drug …

  • Asia-Pacific, Led by China, Drive the Global Methanol Industry
  • China is driving the global methanol industry, with tremendous demand from both its energy and petrochemicals sectors. It accounts for 87.9% of Asia-Pacific’s (APAC) methanol capacity, and 51.9% of the global methanol capacity. Despite a large planned capacity increase in …

  • Diagnostic X-ray Imaging Market worth $4.0 billion by 2020
  • GlobalData estimates that the global diagnostic X-ray imaging market, worth $2.4 billion in 2012, will reach almost $4.0 billion by 2020, increasing at a Compound Annual Growth Rate (CAGR) of 6.7% during the forecast period. Many players are active in …

  • Graft-Versus-Host Disease Market Forecast to 2023
  • Graft-versus-host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT) that occurs when the donated (graft) cells are rejected and attack the host’s cells as foreign. GVHD can progress from mild to severe forms as either …

  • Point-Of-Care Diagnostics / Testing Market by Products (Glucose Monitoring & Infectious Diseases Testing Kits, Cardiac & Tumor Markers), by End Users (Self & Professional Monitoring), Over the Counter & Prescription Based – Global Forecast to 2018
    Published: 12-Sep-2014        Price: US $4650 Onwards        Pages: 320
    The global POC diagnostics market is estimated to grow at a lower CAGR in developed countries; however, it is expected to witness high growth in emerging countries such as China, India, and Brazil. Factors such as rising prevalence of lifestyle and infectious diseases, increasing usage of home-based POC devices, technological advancements, and decreasing number of technicians in the central labs are propelling the growth of the POC diagnostics market. However, factors such as lack of alignment w......
  • POCT Market in China 2014-2018
    Published: 10-Sep-2014        Price: US $2500 Onwards        Pages: 76
    POCT, also called near-patient testing, is performed outside a clinical laboratory. It helps in making fast clinical decisions, and hence in administrating appropriate treatments and medication. POCT is gaining popularity due to the increasing incidence and prevalence of lifestyle diseases such as diabetes, heart disease, and obesity. It is generally cost-effective and user-friendly. POCT devices are standardized to minimize errors during the diagnosis of patients. POCT plays a major role in imp......
  • Breast Cancer Screening (Mammography, MRI & Ultrasound) Market & Forecast – Worldwide
    Published: 9-Sep-2014        Price: US $1490 Onwards        Pages: 258
    Breast cancer is the most common cancer among women in both the developed and developing world. Worldwide Breast Cancer Screening Market was in double digit Billion US$ for 2013. United States is the leading market for breast cancer screening globally. China is expected to maintain its 2nd position in the forecasting period due to hefty number of breast cancer cases.  Worldwide Breast Cancer MRI Screening Market and Breast Cancer Ultrasound Screening Market are also growing year on year. Wor......
  • Freeze Drying / Lyophilization Equipment Market by Scale (Lab, Pilot, & Industrial), Technology (Rotary, Manifold, & Tray – style) & by Accessories (Loading/Unloading System, Vacuum System, Clean-in-Place System, Control System) – Global Forecast to 2019
    Published: 9-Sep-2014        Price: US $4650 Onwards        Pages: 190
    The freeze drying equipment market provided in this report covers both, freeze drying systems or freeze dryers and freeze drying accessories. The equipment market is further segmented on the basis of scale of operations and technology. Based on the scale of operations the freeze drying equipment market is segmented as lab-scale, pilot-scale, and industrial-scale freeze dryers; whereas, based on the technology, the freeze drying market is segmented as manifold freeze dryers, rotary freeze dryers,......
  • Immunoassay Automation Trends 2014
    Published: 4-Sep-2014        Price: US $2500 Onwards        Pages: 56
    Executive Summary This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on immunoassays and their automation carried out in August 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to partially update HTStec’s previous ELISA Trends report (dated June 2012). The questionnaire was compiled to meet the needs, requirements and interests of the immunoassay vendor community. The objective w......
  • Companion Diagnostics Market by Technology (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry), Application (Breast, Lung cancer), & by End-user (Pharmaceutical Companies, Reference Lab)] – Global Trends & Forecasts to 2019
    Published: 2-Sep-2014        Price: US $4650 Onwards        Pages: 142
    The global companion diagnostics market is expected to grow at a CAGR of 22.7% from 2014 to 2019. Factors such as rising need for personalized medicine in cancer treatment, growing adoption of companion diagnostics by the pharmaceutical industry, support from regulatory authorities, and emerging technologies such as next-generation sequencing (NGS) are expected to boost the global companion diagnostics market. Among technologies, PCR is the most preferred test in the companion diagnostics mar......
  • Market Snapshot: Mammography Systems 2006 to 2020 – Americas (US, Canada, Brazil, Mexico)
    Published: 1-Sep-2014        Price: US $1750 Onwards        Pages: 42
    GBI Research’s report, “Market Snapshot: Mammography Systems 2006 to 2020 Americas (US, Canada, Brazil, Mexico)” provides quantitative analysis of the two mammography systems market segments: full field mammography systems and film-screen mammography systems. The analysis includes market size data by revenue and volume over the 2006–2020 period for the following countries: the US, Canada, Brazil and Mexico It uses data and information sourced from proprietary databases, primary and secon......
  • Global Thermometer Market to 2018 – Market Size, Growth, and Forecasts in Nearly 60 Countries
    Published: 1-Sep-2014        Price: US $2624 Onwards        
    This comprehensive publication enables readers the critical perspectives to be able to evaluate the world market for thermometers. The publication provides the market size, growth and forecasts at the global level as well as for the following countries: Argentina, Armenia, Australia, Austria, Azerbaijan, Bangladesh, Belgium, Bulgaria, Canada, Chile, China, Colombia, Czech Republic, Denmark, Ecuador, Egypt, Finland, France, Georgia, Germany, Greece, Hungary, India, Indonesia, Iran, Ireland, It......
  • Future Horizons and Growth Strategies in the German Hemostasis Diagnostic Testing Market 2014: Supplier Shares and Country Forecasts
    Published: 28-Aug-2014        Price: US $6100 Onwards        Pages: 406
    This comprehensive report contains 406 pages, 38 tables, and is designed to help current suppliers and potential market entrants identify and evaluate business opportunities emerging in the German coagulation testing market during the next five years. The report explores business and technological trends in the German coagulation testing market; provides estimates of the test volume, as well as sales and market shares of leading competitors; compares features of major analyzers; profiles lead......
    Value for Money
    We believe in "optimum utilization of available budget and resources". While servicing our clients' (your) market research requirements, we keep the same approach in focus to help you get the best value for your $$s.
    Ever Growing Inventory
    Ranging from the smallest feasible / required data (datasheets, data facts, SWOT analysis, company profiles, etc) to full research reports that help you make decisions, our inventory is updated almost on a daily basis with the latest industry reports from domain experts that track more than 5000 niche sectors.
    One Stop Solution
    Need a custom research report on medical devices market? Require all available business intelligence on 3D printing industry? Exploring F&B sector of a particular country/region? is your one-stop-solution to all market intelligence needs. We not only offer custom research and consulting services, we also "bundle" reports to meet your needs and help you fetch the data analysis you require for your business.
    Dedicated Client Engagement
    Not limited to only "finding" relevant reports for you, our client engagement team dedicates its efforts to understand your "business need" and accordingly maps available research data to help you move forward. Call "your" client engagement executive any time of your day and get your questions answered in order to make the correct business decision.
    Saving Time and Efforts
    Simply share your research requirement details with us and let us do all the hard work to find required intelligence for you. When you add up our "one stop solution" and "dedicated client engagement" services mentioned above, you obviously know the time and effort saving you do by working with us.
    Payment Flexibility
    Working with Fortune 500 organizations, we understand the importance of being flexible for payments. Share your payment terms with us and we will surely match up to them to ensure you get access to required business intelligence data without having to wait for the payment to be done.
    Post-Purchase Research Support
    Have questions after reading a report / datasheet bought through us? Not sure about the methodology used for data available in the research? Talk to us / Share your questions with us and if required, we will connect you with the analyst(s)/author(s) of the report(s) and ensure you get satisfactory answers for the same. Need more data / analysis / report(s) on the topic of your research/project? The team is here for you 24X7 to support you with your post-purchase requirements. Subscription Offers & Packages (Get in touch with us for more details - [email protected] / +1 888 391 5441 )
    • Ad Hoc
    • Pay - as - you - go / Bucket Subscriptions
    • Fixed Cost for #of reports
    • Customize / Personalize as per your needs