Automated Patch Clamping Trends 2014

Publisher Name :
Date: 17-Apr-2014
No. of pages: 54

Executive Summary

  • This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on ion channel drug screening using automated patch clamping (APC) technology carried out in March 2014.
  • The study was initiated by HTStec as part of its ongoing tracking of life science marketplaces. The questionnaire was compiled to meet the needs and interests of ephys/APC vendor community.
  • The objective of this global benchmarking study was to comprehensively document current practices, preferences and metrics in ion channel drug screening using APC technology. It also seeks to chart the emergence of new 384-well APC systems, what determines APC consumable budgets, and most prevents end-users making greater use of APC consumables. In addition, a secondary focus was to understand respondents’ interests and requirements in using a new APC technology for the analysis of adherent cellular 2D networks.
  • Equal emphasis was given to soliciting opinion from Pharma, Other Screening Labs and Academic Research segments in North America, Europe and Japan.
  • The survey looked at the following aspects of ion channel screening using APC technology, as practiced to date (2014) and in some cases as predicted for the future (2016): ion channels classes of greatest interest; ion channels that have proved most difficult to run as primary screens; number of ion channel programs investigated; primary drivers for initiating a new ion channel programs; areas of drug discovery applying APC technologies; typical size of the compound library in drug discovery areas using an APC platform; number of APC patch wells expected to processed per year; proportion of APC assays using different cell types; current access to APC ion channel platforms; preferred vendor’s APC systems for different criteria; likelihood of purchasing a new APC platform over the next few years; factors that most influence a decision to purchase a particular APC platform; APC consumables budget for ion channel screening and how they are determined; what factors most prevent making greater use of APC consumables today; whether the recent introduction of new 384-well APC screening platforms will affect screening activities; prohibitive and stimulative 384-well APC consumable pricepoints; and awareness of the FDA CIPA working group and its potential impact on safety assays undertaken. With respect to a new APC system for adherent 2D cellular networks the following were investigated: technologies already used to obtain information on cell-cell communication within cellular 2D networks; what respondents most want to analyze with the system; applications most suited to the system; cell types most likely to be used with the system; main advantages of the system; impact of the potential disadvantages of the system; features essential for the adoption and exploitation of the system; optimal patch combinations; usefulness of the potential throughput likely to be achieved with the system; preferred routes to access and fit to existing workflow of the system; reasonable price to pay for the APC system; likelihood of future purchasing of the system; reasonable APC consumable pricing for the system; and interest to receive more information/testing of the system.
  • The survey questionnaire consisted of 32 mainly multi-choice questions. In addition, there were 6 questions related solely to survey demographics.
  • The survey collected 88 validated responses, of these 63% provided comprehensive input.
  • Survey responses were geographically split: 34% North America; 31% Europe; 30% Japan; 2% China; 2% Rest of World; and 1% India.
  • Survey respondents were drawn from persons or groups actively involved in ion channel screening, selectivity profiling and safety assessment against ion channel liabilities using APC systems.
  • Respondents represented: 20 Medium-Small Pharma; 17 University/ Research Institute/Government Labs/ Not-for-Profit; 16 Large Pharma; 15 Biotech Company; 9 Contract Research Organisation; 6 Biopharma; 2 Academic Screening Center; 1 Agrochemical/Agri-Biotech Company; 1 Tobacco Company and 1 Other.
  • Most survey respondents had a senior job role or position which was in descending order: 20 research scientists/associates; 20 senior scientists/researchers; 12 principal investigators; 9 section/group leaders; 5 post-docs; 5 department heads; 5 directors; 4 lab managers; 4 professors/assistant professors; 2 vice presidents; and 2 others.
  • Survey results were expressed as an average of all survey respondents. In addition, where appropriate the data was reanalyzed after sub-division into the following 6 survey groups: 1) Pharma; 2) Other Screening Labs; 3) Academic Research; 4) Europe; 5) North America; and 6) Japan.
  • The ion channel research activity most undertaken by respondents was secondary screening.
  • The class of ion channels of most interest was voltage-gated potassium channels. The class of ion channels most experienced difficulty running as primary screens was voltage-gated calcium channels.
  • A median of 3 ion channel programs were under investigation in respondent’s organisation.
  • The primary driver for initiating a new ion channel program was the disease focus of the company.
  • APC technologies were most used today for assay development and hits-to-leads (lead optimization).
  • The median compound library size tested using APC was: 1K-5K for primary screening/HTS; <1K for all hit-to-lead follow-up; and <1K for early non-compliant hERG liability testing.
  • The median number of APC wells processed/year was: 5K-10K for primary screening/HTS; 1K-5K for all hit-to-lead follow-up; and 1K-5K for early non-compliant hERG liability testing.
  • The cell type they most used for APC assays today was recombinant cell lines.
  • The most common APC system available for use in respondents’ labs was the Sophion QPatch 8, 16 or HT.
  • From current prevalence of APC instruments Molecular Devices & Sophion have the greatest vendor share.
  • Of a list of relevant criteria Molecular Devices was the preferred vendor’s APC system with respect cost per consumable, cost per data point and throughput. Sophion was the preferred vendor’s APC system with respect to the 11 other important criteria rated.
  • The median likelihood respondents will purchase a new APC platform over the next few years (by end of 2016) was low (<10% purchasing probability).
  • APC platforms currently most appealing for purchasing were Sophion Qube & Nanion Syncropatch 384PE.
  • The quality of the results was the factor which would most influence a decision to purchase a particular brand/model of APC platform.
  • The median annual APC consumable budget was $50K-$100K/year today.
  • Several bottom-up models were developed around the respondent’s feedback to calculate the global APC markets. In 2014 these were estimated to be around $140M for APC consumables and $38M for new APC platforms. Segmentation & some CAGR estimates are in the full report.
  • The APC consumable budget for ion channel testing of most respondents was not fixed i.e. it can be adjusted to reflect cost changes per data point.
  • The factors that most prevent greater use of APC consumables today were the high cost of APC consumables and lack of ion channel projects.
  • The most predicted effect of the introduction of new 384-well APC screening platforms was to increase the number of data points screened, but with a similar consumable budget.
  • For new 384-well APC screening platforms the median prohibitive pricepoint (i.e. limits use to certain applications & inhibits adoption) was $1.00 per APC data point and $350-$450 per 384-well patch plate.
  • The majority were aware of the FDA CIPA working group where the cardiac risk panel was questioned.
  • The most investigated technology to obtain information on cell-cell communication within a 2D cellular network was manual patch clamp.
  • A new APC system in development for the analysis whole-cell and cell-attached-measurements of individual cells (e.g. neural or cardiac) in an adherent cellular 2D network was presented. The following feedback was obtained with respect to the technology in general or to the proposed academic APC system: 1) analyzing more than one adherent cell from a network in parallel was rated where greatest interest resides; 2) analyzing neuronal networks in general was rated the most suitable application; 3) primary neurons and recombinant cell lines were the cell types most would like to investigate; 4) allows for analysis of cell-cell communication was ranked as the greatest advantage; 5) the need to invest in a new APC system to measure cellular 2D networks was rated the biggest limitation; 6) extracellular perfusion of the whole well was selected as the most essential feature for adopting and exploiting the system; 7) the most wanted patch combination was 100-150 μm patch-to-patch distance, 2 patch sites per chip; 8) the throughput detailed (10 networks per day) was moderately useful in all drug discovery areas, apart from primary screening/HTS; 9) the preferred route to access was via a fee-for-service provider as an addition to current patch-clamp techniques; 10) the median reasonable price was $100K per system; 11) the median probability of purchasing when it becomes available was overall low (<10%), but medium (10-50%) in academic labs; 12) the median reasonable price for an APC consumable was $100-$200 per single chip; and 13) 24 labs want to receive more information and 17 labs want to test the academic APC system. Feedback on the proposed pharmaceutical APC system is given the full report.
  • The full report provides the data, details of the breakdown of the responses for each question, its segmentation and the estimates for the future (2016). It also highlights some interesting differences between the survey groups.

Automated Patch Clamping Trends 2014 published by HTStec Ltd in 17 April 2014. This report consists of 54 Pages and the price starts from US $ 2500.

Automated Patch Clamping Trends 2014

Table of Contents

Executive Summary 2
Survey Methodology 5
Respondent’s Organisation And Response To The Survey 6
Respondent’s Company Or Organisational Origin 7 Respondent’s Geographic Origin 8
Respondent’s Job Role 9
Ion Channel Research Activities Undertaken By Respondents 10
Classes of Ion Channels of Most Interest to Respondents 11
Classes of Ion Channels Most Difficult To Screen 12
Number Of Ion Channel Drug Discovery Programs Under Investigation (1) 13
Number Of Ion Channel Drug Discovery Programs Under Investigation (2) 14
Primary Drivers For Initiating A New Ion Channel Program 15
Use Of APC Technologies In Different Drug Discovery Areas 16
Compound Library Size Tested Using An APC Platform 17
Number Of APC Well Processed Per Year Using An APC Platform 18
Summary of Survey Findings (1) 19
Proportion Of Different Cell Types Used In APC Assays 21
APC Platforms Respondents Currently Have Access To 22
Preferred Vendor’s APC System For Various Criteria 23
Likelihood Will Purchase A New APC Platform Over The Next Few Years 24
Number Of Units Of A New APC Platform Respondents Might Purchase 25
APC Platforms Most Appealing For Future Purchasing 26
Factors Which Would Most Influence Purchasing Of APC Platform 27
APC Consumables Budget 28
APC Market Estimates (1) 29
APC Market Estimates (2) 30
How APC Consumable Budget For Ion Channel Testing Is Determined 31
Factors Preventing Greater Use Of APC Consumables 32
How New 384 APC Platforms May Affect Screening Activities 33
APC Consumable Pricepoints For New 384-Well APC Screening Platforms 34
Awareness of FDA CIPA Working Group And Impact On Safety Assays 35
Summary of Survey Findings (2) 36
New APC System for 2D Cellular Networks (Technology Description) 38
Technologies Investigated To Obtain Information On Cell-Cell Communication With 2D Cellular Networks (1) 39 Technologies Investigated To Obtain Information On Cell-Cell Communication With 2D Cellular Networks (2) 40 What Respondents Most Want To Analyze With A New APC System For 2D Cellular Networks 41
Applications Most Suited To An APC System For 2D Cellular Networks 42
Preferred Cell Types For An APC Analysis System For 2D Cellular Networks 43
Main Advantages Of An APC System For 2D Cellular Networks 44
Potential Disadvantages Of An APC System For Adherent Cellular 2D Networks 45
Features Needed In A New APC System For Analysis Of Cellular 2D Networks 46
Patch Combinations Most Optimal For Respondent’s Research 47
Throughput Needed For Analysis 2D Cellular Networks 48
Preferred Route To Access A New APC System For Cellular 2D Networks 49
Reasonable Price To Pay For A New APC System For 2D Cellular Networks Networks 50
Likelihood Of Purchasing A New APC System For Cellular 2D Networks 51
Reasonable Price To Pay For APC Consumables For 2D Cellular Networks 52
Respondents Interested In More Info Or Testing The New APC System For 2D Cellular Networks 53
Summary of Survey Findings (3) 54

  • Water Treatment Chemicals Market to be driven by Increasing Demand from Developing Economies
    The global market for water treatment chemicals is growing at a steady pace with rapid urbanization and high demand from end-users. Water treatment chemicals are used for treating municipal water as well as agricultural wastewater. With higher demand for clean, drinking water with increasing population and increase in the number of industries, the global market [...]
  • Rise in Prevalence of Allergic Diseases Driving the Global Allergy Diagnostics Market
    With rise in the incidences of allergic diseases in the world, the global allergy diagnostics market has also witnessed steady growth. In recent years, there has been an increase in the number of people suffering from different allergies, particularly food allergies and drug allergies. The number of people suffering from asthma has also increased in [...]
  • Global Video Surveillance Market Driven by Increasing Demand for Security
    The global market for video surveillance has been witnessing steady growth with increase in demand for advanced surveillance systems by different law enforcement agencies. Increase in adoption of video surveillance by different sectors such as banking and finance, healthcare, transportation, and retail is one of the major drivers in the market. In 2013, the global [...]
  • Global Empty Capsules Market Driven by Growth in Pharmaceutical Industry
    With rapid growth in the pharmaceutical industry, the market for empty capsules has also grown at a steady pace. Some of the factors which are driving the growth of the empty capsules market are rise in aging population which is increasing the demand for capsule based drugs, technological advancement and increase in demand from the [...]
  • Global Aramid Fiber Industry to Witness High Growth in the Future
    With increasing use of aramid fibers in various industries, the global market for aramid fibers has grown significantly in recent years. Aramid fibers have a number of properties such as low density, heat resistance, high tensile strength, abrasion resistance, chemical resistance and impact resistance.  Asia-Pacific is the largest market for aramid fibers, followed by North [...]
  • Graft-Versus-Host Disease (GVHD) Treatment Market worth $407 million by 2018
  • The graft-versus-host disease (GVHD) treatment market value will increase from $297 million in 2013 to $407 million by 2018, at a Compound Annual Growth Rate (CAGR) of 6.59%, according to research and consulting firm GlobalData. The company’s latest report* states …

  • Poland Pharmaceutical Industry Growing at 8.3% CAGR to 2020
  • Factors such as the growing elderly population, increasing availability of affordable medicines, and transparent regulatory guidelines will provide the necessary impetus for the growth of the Polish pharmaceutical market, but a decrease in mark-up prices and the country’s stringent drug …

  • Asia-Pacific, Led by China, Drive the Global Methanol Industry
  • China is driving the global methanol industry, with tremendous demand from both its energy and petrochemicals sectors. It accounts for 87.9% of Asia-Pacific’s (APAC) methanol capacity, and 51.9% of the global methanol capacity. Despite a large planned capacity increase in …

  • Diagnostic X-ray Imaging Market worth $4.0 billion by 2020
  • GlobalData estimates that the global diagnostic X-ray imaging market, worth $2.4 billion in 2012, will reach almost $4.0 billion by 2020, increasing at a Compound Annual Growth Rate (CAGR) of 6.7% during the forecast period. Many players are active in …

  • Graft-Versus-Host Disease Market Forecast to 2023
  • Graft-versus-host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT) that occurs when the donated (graft) cells are rejected and attack the host’s cells as foreign. GVHD can progress from mild to severe forms as either …

  • 2014 Deep Research Report on Global Polarimeter Industry
    Published: 15-Dec-2014        Price: US $2600 Onwards        Pages: 129
    This is a professional and depth research report on Global Polarimeter industry. For overview analysis, the report introduces Polarimeter basic information including definition, classification, application, industry chain structure, industry overview, policy analysis, and news analysis, etc. For international and China market analysis, the report analyzes Polarimeter markets in China and other countries or regions (such as US, Europe, Japan, etc.) by presenting research on global products ......
  • Global Digital X-ray Market 2015-2019
    Published: 10-Dec-2014        Price: US $2500 Onwards        Pages: 92
    Digital X-ray systems are used for diagnosing and treatment of diseases by creating and recording images. The X-ray images captured using a digital system are no different from that of screen-film radiography. In a digital system, screen-film detectors and sensors generate the digital image. Digital detectors allow full implementation of image archiving and communication; these images can be transferred from one operational unit to another, and can be accessed by means of web-based technology wi......
  • Allergy Diagnostics Market by Allergen Source (Food Allergens, Inhaled Allergens), Product (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) & by End User (Hospital, Diagnostic Laboratory) – Global Forecast to 2019
    Published: 8-Dec-2014        Price: US $4650 Onwards        Pages: 210
    Allergy diagnostics is used to determine the nature and treatment course of allergic diseases. According to an editorial piece published in the World Allergy Journal in May 2014, about 300 million people suffered from asthma and about 200 to 250 million people suffered from food allergies in 2013. The prevalence of asthma has risen rapidly across the globe. According to the World Health Organization (WHO), about 300 million asthma cases were recorded globally in 2013 and are expected to increase......
  • 2014 Deep Research Report on Global Nuclear Magnetic Resonance Spectrometer (NMR) Industry
    Published: 2-Dec-2014        Price: US $2200 Onwards        Pages: 109
    This is a professional and depth research report on Global Nuclear Magnetic Resonance Spectrometer (NMR) industry. For overview analysis, the report introduces Nuclear Magnetic Resonance Spectrometer (NMR) basic information including definition, classification, application, industry chain structure, industry overview, policy analysis, and news analysis, etc. For international and China market analysis, the report analyzes Nuclear Magnetic Resonance Spectrometer (NMR) markets in China and o......
  • China In Vitro Diagnostics (IVD) Market, Forecast & Companies Analysis
    Published: 2-Dec-2014        Price: US $1400 Onwards        Pages: 77
    This is 3rd edition report on In Vitro Diagnostics sector by Renub Research. Report titled “China In Vitro Diagnostics (IVD) Market, Forecast & Companies Analysis” provides a comprehensive assessment of the fast–evolving, high–growth IVD Market in China. This 77 page report with 34 Figures studies the China IVD market from 4 view points: 1) Market and Forecast 2) Segment Wise Market & Forecast 3) Development Environment & Regulatory Status in China IVD market 4) Company......
  • Cancer Diagnostics Partnering Terms and Agreements
    Published: 1-Dec-2014        Price: US $2995 Onwards        Pages: 1290
    The Cancer Diagnostics Partnering Agreements report provides an understanding and access to the cancer diagnostics partnering deals and agreements entered into by the worlds leading healthcare companies. Trends in cancer diagnostics partnering deals Disclosed headlines, upfronts, milestones and royalties by stage of development Cancer diagnostics partnering contract documents Top cancer diagnostics deals by value The Cancer Diagnostics Partnering Agreements report provides an unders......
  • In Vitro Diagnostics Markets in China
    Published: 1-Dec-2014        Price: US $4000 Onwards        Pages: 168
    China's demand for In Vitro Diagnostics has grown at a fast pace in the past decade. In the next decade, both production and demand will continue to grow. The Chinese economy maintains a high speed growth which has been stimulated by the consecutive increases of industrial output, import & export, consumer consumption and capital investment for over two decades. This new study examines China's economic trends, investment environment, industry development, supply and demand, industry capacity......
  • Legionella: 2014 Supplier Shares, Test Volume and Sales Forecasts by Country and Market Segment: Hospitals, Labs, POC Locations–France, Germany, Italy, Japan, Spain, UK, USA
    Published: 28-Nov-2014        Price: US $2900 Onwards        
    This report presents test volumes and sale forecasts for the US, Europe (France, Germany, Italy, Spain, UK) and Japan. The report provides volume and sales forecasts for Legionella tests performed in the following market segments: Hospitals Commercial/Private Labs Physician Offices Public Health Labs In addition to test volume and sales projections, the report presents sales and market share estimates for major suppliers of Legionella tests.......
  • HIV/AIDS: 2014 Supplier Shares, Test Volume and Sales Forecasts by Country and Market Segment: Hospitals, Blood Banks, Labs, POC Locations–France, Germany, Italy, Japan, Spain, UK, USA
    Published: 28-Nov-2014        Price: US $1850 Onwards        
    This 7-country DataPack presents test volumes, sale forecasts and supplier shares for the US, Europe (France, Germany, Italy, Spain, UK) and Japan for HIV-1/2, HIV Ag, Western Blot and other confirmatory assays performed in the following markets: Hospitals Commercial/Private Labs Blood Banks Public Health Labs Physician Offices ......
  • SERVICES
    Value for Money
    We believe in "optimum utilization of available budget and resources". While servicing our clients' (your) market research requirements, we keep the same approach in focus to help you get the best value for your $$s.
    Ever Growing Inventory
    Ranging from the smallest feasible / required data (datasheets, data facts, SWOT analysis, company profiles, etc) to full research reports that help you make decisions, our inventory is updated almost on a daily basis with the latest industry reports from domain experts that track more than 5000 niche sectors.
    One Stop Solution
    Need a custom research report on medical devices market? Require all available business intelligence on 3D printing industry? Exploring F&B sector of a particular country/region? RnRMarketResearch.com is your one-stop-solution to all market intelligence needs. We not only offer custom research and consulting services, we also "bundle" reports to meet your needs and help you fetch the data analysis you require for your business.
    Dedicated Client Engagement
    Not limited to only "finding" relevant reports for you, our client engagement team dedicates its efforts to understand your "business need" and accordingly maps available research data to help you move forward. Call "your" client engagement executive any time of your day and get your questions answered in order to make the correct business decision.
    Saving Time and Efforts
    Simply share your research requirement details with us and let us do all the hard work to find required intelligence for you. When you add up our "one stop solution" and "dedicated client engagement" services mentioned above, you obviously know the time and effort saving you do by working with us.
    Payment Flexibility
    Working with Fortune 500 organizations, we understand the importance of being flexible for payments. Share your payment terms with us and we will surely match up to them to ensure you get access to required business intelligence data without having to wait for the payment to be done.
    Post-Purchase Research Support
    Have questions after reading a report / datasheet bought through us? Not sure about the methodology used for data available in the research? Talk to us / Share your questions with us and if required, we will connect you with the analyst(s)/author(s) of the report(s) and ensure you get satisfactory answers for the same. Need more data / analysis / report(s) on the topic of your research/project? The RnRMarketResearch.com team is here for you 24X7 to support you with your post-purchase requirements. Subscription Offers & Packages (Get in touch with us for more details - [email protected] / +1 888 391 5441 )
    • Ad Hoc
    • Pay - as - you - go / Bucket Subscriptions
    • Fixed Cost for #of reports
    • Customize / Personalize as per your needs