Amyloidosis - Pipeline Review, H2 2018

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Date: 17-Jul-2018
No. of pages: 196
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Amyloidosis - Pipeline Review, H2 2018

Summary

Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Amyloidosis - Pipeline Review, H2 2018, provides an overview of the Amyloidosis (Metabolic Disorders) pipeline landscape.

Abnormal accumulation of amyloid protein in the tissues results in a group of diseases known as amyloidosis. It may affect the shape and functioning of the organ eventually leading to organ failure. Predisposing factors are misfolding of abnormal protein called the light chain and its subsequent deposition in the body. It may also occur as a result of dialysis. Symptoms include fatigue, chest pain, swelling and breathing problems. Amyloidosis can be managed by transplant and, medication such as diuretics and chemotherapy drugs.

Report Highlights

Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Amyloidosis - Pipeline Review, H2 2018, provides comprehensive information on the therapeutics under development for Amyloidosis (Metabolic Disorders), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.

The Amyloidosis (Metabolic Disorders) pipeline guide also reviews of key players involved in therapeutic development for Amyloidosis and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Filing rejected/Withdrawn, Phase III, Phase II, Phase I, Preclinical and Discovery stages are 3, 2, 2, 10, 6, 8 and 3 respectively. Similarly, the Universities portfolio in Phase II, Preclinical and Discovery stages comprises 2, 1 and 2 molecules, respectively.

Amyloidosis (Metabolic Disorders) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

- The pipeline guide provides a snapshot of the global therapeutic landscape of Amyloidosis (Metabolic Disorders).

- The pipeline guide reviews pipeline therapeutics for Amyloidosis (Metabolic Disorders) by companies and universities/research institutes based on information derived from company and industry-specific sources.

- The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.

- The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.

- The pipeline guide reviews key companies involved in Amyloidosis (Metabolic Disorders) therapeutics and enlists all their major and minor projects.

- The pipeline guide evaluates Amyloidosis (Metabolic Disorders) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.

- The pipeline guide encapsulates all the dormant and discontinued pipeline projects.

- The pipeline guide reviews latest news related to pipeline therapeutics for Amyloidosis (Metabolic Disorders)

Reasons to buy

- Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.

- Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.

- Find and recognize significant and varied types of therapeutics under development for Amyloidosis (Metabolic Disorders).

- Classify potential new clients or partners in the target demographic.

- Develop tactical initiatives by understanding the focus areas of leading companies.

- Plan mergers and acquisitions meritoriously by identifying key players and it's most promising pipeline therapeutics.

- Formulate corrective measures for pipeline projects by understanding Amyloidosis (Metabolic Disorders) pipeline depth and focus of Indication therapeutics.

- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.

- Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.

Amyloidosis - Pipeline Review, H2 2018

Table of Contents
List of Tables
List of Figures
Introduction
Global Markets Direct Report Coverage
Amyloidosis - Overview
Amyloidosis - Therapeutics Development
Pipeline Overview
Pipeline by Companies
Pipeline by Universities/Institutes
Products under Development by Companies
Products under Development by Universities/Institutes
Amyloidosis - Therapeutics Assessment
Assessment by Target
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Amyloidosis - Companies Involved in Therapeutics Development
Akcea Therapeutics Inc
Alnylam Pharmaceuticals Inc
Amgen Inc
Arcturus Therapeutics Ltd
Bsim2
Celgene Corp
Chugai Pharmaceutical Co Ltd
GlaxoSmithKline Plc
Johnson & Johnson
Millennium Pharmaceuticals Inc
Neurimmune Holding AG
Novartis AG
Oncopeptides AB
Pfizer Inc
Prothena Corp Plc
R Pharm
Regeneron Pharmaceuticals Inc
Spectrum Pharmaceuticals Inc
Amyloidosis - Drug Profiles
AG-10 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
AKCEA-TTR-LRx - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
ALN-TTRsc02 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
CAEL-101 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
canakinumab - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
carfilzomib - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Cellular Immunotherapy to Target CS1 for Metabolic Disorders and Oncology - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
CLR-01 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
daratumumab - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
dezamizumab - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
dezamizumab + miridesap - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
doxycycline hyclate - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
EDE-1307 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
eprodisate disodium - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
GSK-3039294 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
inotersen sodium - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
ixazomib citrate - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
LUNAR-TTR - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
melphalan - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
melphalan flufenamide hydrochloride - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
miridesap - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Monoclonal Antibodies to Inhibit LECT2 for Amyloidosis - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Monoclonal Antibody to Target CD66b for Blood Cancer and Metabolic Disorders - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
NI-301 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
NPT-189 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Oligonucleotides to Inhibit Transthyretin for Amyloidosis - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
patisiran - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
pomalidomide - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
PRX-004 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
RPH-104 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecule to Inhibit Amyloid Beta Peptide for Alzheimer's Disease and Amyloidosis - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Activate ATF6 for Amyloidosis - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit Transthyretin Related Amyloid Protein for Familial Amyloidotic Cardiomyopathy - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit Transthyretin Related Amyloid Protein for Familial Amyloidotic Polyneuropathy - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
tafamidis meglumine - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
tocilizumab - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
tolcapone - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
VERU-111 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
VERU-112 - Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Amyloidosis - Dormant Projects
Amyloidosis - Discontinued Products
Amyloidosis - Product Development Milestones
Featured News & Press Releases
Jul 05, 2018: New England Journal of Medicine Publishes Results from Pivotal Study of TEGSEDI for the Treatment of Hereditary ATTR Amyloidosis
Jul 04, 2018: Alnylam Announces Publication of APOLLO Phase 3 Clinical Study Results for Investigational RNAi Therapeutic Patisiran in The New England Journal of Medicine
Jun 25, 2018: Caelum Biosciences Announces Complete Cardiac Data Analysis from Phase 1b Trial of CAEL-101 in AL Amyloidosis
Jun 18, 2018: Caelum Biosciences Announces Presentation of Complete Cardiac Data Analysis from Phase 1b Trial of CAEL-101 in AL Amyloidosis at American Society of Echocardiography 29th Annual Scientific Sessions
Jun 15, 2018: Alnylam to Report New Clinical Results for Patisiran at the 4th Congress of the European Academy of Neurology
Jun 04, 2018: Alnylam Receives Orphan Drug Designation from the United States Food & Drug Administration for ALN-TTRsc02, a Subcutaneously Delivered Investigational RNAi Therapeutic for the Treatment of Transthyretin-Mediated Amyloidosis
May 23, 2018: FDA Grants Breakthrough Therapy Designation for Tafamidis for the Treatment of Patients with Transthyretin Cardiomyopathy
May 08, 2018: Alnylam Reports Preclinical Data Demonstrating Central Nervous System Delivery of RNAi Therapeutics
May 03, 2018: Eidos Therapeutics Initiates Phase 2 Clinical Trial for AG10 Targeting Transthyretin Amyloidosis Cardiomyopathy
May 03, 2018: Eidos Therapeutics Initiates Phase 2 Clinical Trial for AG10 Targeting Transthyretin Amyloidosis Cardiomyopathy
Apr 25, 2018: Genmab to Present Data on Daratumumab at 2018 ASCO Annual Meeting
Apr 24, 2018: Alnylam Reports New Clinical Results from the APOLLO Phase 3 Study of Patisiran at the American Academy of Neurology 2018 Annual Meeting
Apr 23, 2018: Alnylam Receives Positive Opinion for Orphan Drug Designation in the European Union for ALN-TTRsc02, a Subcutaneously Delivered Investigational RNAi Therapeutic for the Treatment of Transthyretin-Mediated Amyloidosis
Apr 21, 2018: Akcea Therapeutics to Present Data on Inotersen for the Treatment of hATTR Amyloidosis at the 2018 American Academy of Neurology Annual Meeting
Apr 03, 2018: Silence Therapeutics: Litigation Update (Portugal and US)
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer

List of Tables
Number of Products under Development for Amyloidosis, H2 2018
Number of Products under Development by Companies, H2 2018
Number of Products under Development by Companies, H2 2018 (Contd..1), H2 2018
Number of Products under Development by Universities/Institutes, H2 2018
Products under Development by Companies, H2 2018
Products under Development by Companies, H2 2018 (Contd..1), H2 2018
Products under Development by Companies, H2 2018 (Contd..2), H2 2018
Products under Development by Universities/Institutes, H2 2018
Number of Products by Stage and Target, H2 2018
Number of Products by Stage and Mechanism of Action, H2 2018
Number of Products by Stage and Route of Administration, H2 2018
Number of Products by Stage and Molecule Type, H2 2018
Amyloidosis - Pipeline by Akcea Therapeutics Inc, H2 2018
Amyloidosis - Pipeline by Alnylam Pharmaceuticals Inc, H2 2018
Amyloidosis - Pipeline by Amgen Inc, H2 2018
Amyloidosis - Pipeline by Arcturus Therapeutics Ltd, H2 2018
Amyloidosis - Pipeline by Bsim2, H2 2018
Amyloidosis - Pipeline by Celgene Corp, H2 2018
Amyloidosis - Pipeline by Chugai Pharmaceutical Co Ltd, H2 2018
Amyloidosis - Pipeline by GlaxoSmithKline Plc, H2 2018
Amyloidosis - Pipeline by Johnson & Johnson, H2 2018
Amyloidosis - Pipeline by Millennium Pharmaceuticals Inc, H2 2018
Amyloidosis - Pipeline by Neurimmune Holding AG, H2 2018
Amyloidosis - Pipeline by Novartis AG, H2 2018
Amyloidosis - Pipeline by Oncopeptides AB, H2 2018
Amyloidosis - Pipeline by Pfizer Inc, H2 2018
Amyloidosis - Pipeline by Prothena Corp Plc, H2 2018
Amyloidosis - Pipeline by R Pharm, H2 2018
Amyloidosis - Pipeline by Regeneron Pharmaceuticals Inc, H2 2018
Amyloidosis - Pipeline by Spectrum Pharmaceuticals Inc, H2 2018
Amyloidosis - Dormant Projects, H2 2018
Amyloidosis - Discontinued Products, H2 2018

List of Figures
Number of Products under Development for Amyloidosis, H2 2018
Number of Products under Development by Companies, H2 2018
Number of Products under Development by Universities/Institutes, H2 2018
Number of Products by Top 10 Targets, H2 2018
Number of Products by Stage and Top 10 Targets, H2 2018
Number of Products by Top 10 Mechanism of Actions, H2 2018
Number of Products by Stage and Top 10 Mechanism of Actions, H2 2018
Number of Products by Routes of Administration, H2 2018
Number of Products by Stage and Routes of Administration, H2 2018
Number of Products by Molecule Types, H2 2018
Number of Products by Stage and Molecule Types, H2 2018
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