2012-2022 Report on Global CRISPR Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application

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Date: 18-Apr-2017
No. of pages: 104
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The Global CRISPR Market is expected to grow from $XXX million in 2016 and CAGR XX% for the forecasted period of 2017-2022. The gene editing technology has grown significantly in the last decade. The gene editing tools have become more accessible and cost effective which has enabled a thorough understanding of human genome. CRISPR (clustered regularly interspaced short palindromic repeats) is a new gene editing tool which has opened new doors for gene editing. This technology allows researchers to perform microsurgery on genes, precisely and easily, changing a DNA sequence at exact locations on a chromosome. The global market of CRISPR is expected to grow from $XX million in 2016 and CAGR XX% for the forecasted period of 2017-2022.

CRISPR market is expected to grow on the back of several drivers such as increased R&D expenditure on biotechnology, backed by venture capitals, increasing age related genetic disorders, increasing private and government expenditure on genetic research, high prevalence rate of genetic birth disorders and high demand of synthetic genes. Several factors such as limited awareness and little presence in emerging markets are restraints in the path of growth of the market.

The Global CRISPR market is segmented on the basis of application and end users: On the basis of application the market is segmented into Genome Editing, Genetic engineering, gRNA Database/Gene Library, CRISPR Plasmid and vectors so on. CRISPR Plasmid is the highest growing segment due to high demand among scientists and researchers. By end user, the market is segmented into Biotechnology companies, Pharmaceutical companies, Academic and research Institutes, Research and development institutes, Competitive Intelligence, Merger and Acquisitions and Innovation. In end user, the academic and research is highest growing segment due to high level of R&D into genome process, development of new drugs and development of genetically modified organisms and drugs.

The geography analysis consists of North America (US, Canada), Europe (United Kingdom, France, Germany, Spain, Italy), Asia Pacific (India, China, Japan) and Rest of the world. North America is the largest geographical market (2016) in CRISPR because high level of academies and research based in region. Asia-Pacific region is expected to grow at the fastest rate in forecasted period due to increase in number of contract research organization and emergence of drug discovery.

Major industry players in CRISPR market are: Editas Medicine (US), CRISPR therapeutics (Switzerland), GenScript USA Inc. (US), Horizon Discovery Group plc (UK), Integrated DNA Technologies, Inc. (US), Lonza Group Ltd. (Switzerland), New England Biolabs, Inc. (US), OriGene Technologies, Inc. (US), Sangamo Biosciences, Inc. (US), Sigma-Aldrich Corporation (US), Thermo Fisher Scientific, Inc. (US), Transposagen Biopharmaceuticals (US), Santa Cruz Biotechnology (US), Dharmacon (US), ZGene Biotech (TW), Blue Heron Bio (US), Takara Bio (JP), Synthego (US), Mirus Bio (US), Agilent Technologies (US), VCANBIO Cell & Gene Engineering (CN), Shenzhen Jinjia Group (CN), Galaxy Biomed (CN), Tofflon (CN), AOYANG Group (CN), ANKEBIO (CN).

2012-2022 Report on Global CRISPR Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application

Table of Contents
1. Executive Summary 1
1.1 Methodology/Research Approach 1
1.1.1 Research Programs/Design 1
1.1.2 Market Size Estimation 3
1.1.3 Market Breakdown and Data Triangulation 4
1.2 Data Source 5
1.2.1 Secondary Sources 5
1.2.2 Primary Sources 6
1.3 Disclaimer 7
2. Market overview 1
2.1 CRISPR Market overview 1
2.2. Research and Development 4
2.2.1. Scientific Papers Analysis 4
2.2.2. Patent Analysis 5
2.3. CRISPR vs. Conventional Gene Editing Tools 6
2.4 CRISPR: Novel Initiatives 8
2.4.1. CRISPR Cas9 Technology 9
2.4.2. CRISPR as A Gene Editing Tool to Treat Genetic Disorders 11
2.4.3. CRISPR as A Gene Editing Tool In Drug Development 14
2.5 Industry Chain Analysis 16
3. Sector Analysis 18
3.1. Sector Overview 18
3.1.1 Sector Overview of CRISPR 18
3.1.2 Global Major Regions Status of CRISPR 19
3.2 Sector Policy Analysis 19
4 Global CRISPR Market Competition by Vendor 22
5. Company Profiling 23
5.1. Thermo Fisher Scientific (US) 23
5.1.1. Company Basic Information 23
5.1.2. Technology/Product Introduction 23
5.1.3. Expenses, R&D Expenses and R&D Share 23
5.2. Editas Medicine (US) 24
5.2.1. Company Basic Information 24
5.2.2. Technology/Product Introduction 24
5.2.3. Expenses, R&D Expenses and R&D Share 25
5.3. Caribou Biosciences (US) 25
5.3.1. Company Basic Information 25
5.3.2. Technology/Product Introduction 26
5.3.3. Expenses, R&D Expenses and R&D Share 26
5.4. CRISPR therapeutics (CH) 26
5.4.1. Company Basic Information 26
5.4.2. Technology/Product Introduction 27
5.4.3. Expenses, R&D Expenses and R&D Share 27
5.5. Intellia therapeutics, Inc. (US) 27
5.5.1. Company Basic Information 27
5.5.2. Technology/Product Introduction 28
5.5.3. Expenses, R&D Expenses and R&D Share 28
5.6. Cellectis (FR) 28
5.6.1. Company Basic Information 28
5.6.2. Technology/Product Introduction 29
5.6.3. Expenses, R&D Expenses and R&D Share 29
5.5. Horizon Discovery Plc (UK) 30
5.8. Sigma Aldrich (US) 30
5.9. Precision Biosciences (US) 30
5.10. Genscript (US) 30
5.11. Sangamo Biosciences Inc. (US) 30
5.12. Lonza Group Limited (CH) 30
5.13. Integrated DNA Technologies (US) 30
5.14. New England Biolabs (US) 30
5.15. Origene Technologies (US) 30
5.16 Transposagen Biopharmaceuticals (US) 30
5.17 Santa Cruz Biotechnology (US) 30
5.18 Dharmacon (US) 30
5.19 ZGene Biotech (TW) 30
5.20 Blue Heron Bio (US) 30
5.21 Takara Bio (JP) 30
5.22 Synthego (US) 30
5.23 Mirus Bio (US) 31
5.24 Agilent Technologies (US) 31
5.25 VCANBIO Cell & Gene Engineering (CN) 31
5.26 Shenzhen Jinjia Group (CN) 31
5.27 Galaxy Biomed (CN) 31
5.28 Tofflon (CN) 31
5.29 AOYANG Group (CN) 31
5.30 ANKEBIO (CN) 31
6. Geographical Analysis 32
6.1. North America 32
6.1.1. United States 32
6.1.2. Canada 32
6.1.3. RoNA (Rest of North America) 32
6.2. Europe 32
6.2.1. United Kingdom 32
6.2.2. France 32
6.2.3. Germany 33
6.2.4. Spain 33
6.2.5. Italy 33
6.2.6. RoE (Rest of Europe) 33
6.3. Asia Pacific 33
6.3.1. China 33
6.3.2. Japan 33
6.3.3. India 34
6.4. Rest of the World 34
6.4.1. Middle East and Africa 34
6.4.2. Latin America 34
7. Market Determinants 35
7.1. Drivers 35
7.1.1. Rise in Drug Discovery Market 35
7.1.2. Demand for Synthetic Genes 36
7.1.3. High Prevalence of Genetic Birth Disorders 38
7.1.4. Age Related Genetic Disorders 42
7.1.5. Rise in the Healthcare Research and Development Budgets 45
7.1.6. Venture Capital 47
7.1.7. Global Increase in Lifestyle Oriented Diseases & Fatalities 48
7.1.8. GMOS Increase Crop Yields and Promote Efficient Land Use 48
7.2. Restraints 51
7.2.1. Ethical Issues Related to Misuse of CRISPR Gene Editing Tool 51
7.2.2. Limited Awareness 55
7.2.3. Limited Presence in Emerging Markets 55
7.3. Opportunities 56
7.3.1. CRISPR Gene Editing Can Open the Market for Gene Surgery 56
7.3.2. Emerging Contract Research Organization Market in Asia 57
7.4. Challenges 59
7.4.1. Patent Infringement 59
7.4.2. Presence of Alternative Gene Editing Tools 60
8. Market Segmentation 63
8.1. by Application 63
8.1.1. Genome Editing 63
8.1.2. Genetic Engineering 63
8.1.3. gRNA Database/Gene Library 63
8.1.4. CRISPR Plasmid 63
8.1.5. Human Stem Cells 63
8.1.6. Genetically Modified Organisms/Crops 64
8.1.7. Cell Line Engineering 64
8.2. by End User 64
8.2.1. Biotechnology Companies 64
8.2.2. Pharmaceutical Companies 64
8.2.3. Academic Institutes 64
8.2.4. Research and Development Institutes 65
8.3. Competitive Intelligence 65
8.3.1. Merger and Acquisitions 65
8.3.2. Innovation 67
8.3.3. Venture Capital Funding 70
9 Global CRISPR Market Forecast (2017-2022) 71
9.1 Global CRISPR Market (Million USD) Forecast (2017-2022) 71
9.2 Global Market (Million USD) Forecast by Regions (2017-2022) 71
9.2.1 North America CRISPR Market (Million USD) Forecast (2017-2022) 72
9.2.2 Europe CRISPR Market (Million USD) Forecast (2017-2022) 72
9.2.3 Asia-Pacific CRISPR Market (Million USD) Forecast (2017-2022) 72
9.3 Global CRISPR Market (Million USD) Forecast by Application (2017-2022) 72
10 Strategic Recommendation and Conclusion 74
11 Appendix 75
Author List 75
List of Tables and Figures
Table Research Programs/Design for This Report 1
Figure Bottom-up and Top-down Approaches for This Report 4
Figure Data Triangulation 5
Table Key Data Information from Secondary Sources 6
Table Key Data Information from Primary Sources 7
Figure Brief History of CRISPR 2
Figure CRISPR Prokaryotic Antiviral Defense Mechanism 4
Table Global CRISPR Market 2014-2017 (Million US $) 5
Figure Number of Scientific Papers and Growth Rate on CRISPR (2012-2016) 5
Figure Number of Patents and Growth Rate on CRISPR (2012-2016) 6
Figure Institution Authorized of CRISPR Patents by the United States and the EU 6
Figure Representation of ZFNs, TALENs, and CRISPR/Cas9 7
Table Comparison between CRISPR, ZFN and TALENs 7
Table Global Gene Editing Market Share by Editing Tool 8
Figure A CRISPR Way to Fix Faulty Genes 9
Figure Introduction of CRISPR/Cas9 10
Figure Cas9 in Vivo: Bacterial Adaptive Immunity 11
Table Application Description of CRISPR Cas9 Technology 11
Figure Gene Editing Using the CRISPR/Cas9 Technique 12
Figure Genetic Disorders 13
Figure Gene Editing with CRISPR 15
Figure Selected Events and Discoveries Important for Functional Genomics for Drug MoA 16
Figure CRISPR Industry Chain Analysis 17
Table Global Major CRISPR Companies Involved In the Field Of Technology and Cooperation 18
Table Global CRISPR Key Vendors 19
Figure Global Market Share of CRISPR by Major Regions in 2016 20
Table Various Initiatives and Policies under Taken by the Government in Healthcare Sector 20
Table Sector Policy Analysis 20
Figure Researcher Examines a Pork Sample at the Cloning & Genetic Engineering Section of the Beijing Genomics Institute in China 23
Figure Synthetic Gene Circuit 24
Figure Genetic Birth Disorders 26
Table Category of Genetic Diseases 26
Table Age Related Genetic Disorders 31
Figure the Impact of mTORC1 on Diseases of Ageing 32
Table U.S. Department of Health & Human Services Budget (Million USD) Overview 33
Figure Funding (Million USD) from National Natural Science Foundation of China and Growth Rate of CRISPR 34
Figure Venture Capital 35
Table Benefits of GM Crops 36
Table Global Area of Genetic Modified Crop by Countries 1996 to 2015 (Million Hectares) 37
Table Global Area of Genetic Modified Crop in 2014 and 2015: by Country (Million Hectares) 38
Figure Regulatory Policies for Human Germ Cell Transformation in the World 42
Figure Emerging Markets 43
Figure Protocol for Gene Transfer to Joints 45
Figure Early-phase CRISPR-Cas9 Platform Patent Control and Access 47
Figure CRSIPR 49
Figure ZFN 49
Figure TALENs 50
Figure CRISPR Market and Growth Rate by Genome Editing 2014-2017 ($ Million) 51
Figure CRISPR Market and Growth Rate by Genetic Engineering 2014-2017 ($ Million) 51
Figure CRISPR Market and Growth Rate by gRNA Database/Gene Library 2014-2017 ($ Million) 51
Figure CRISPR Market and Growth Rate by CRISPR Plasmid 2014-2017 ($ Million) 51
Figure CRISPR Market and Growth Rate by Human Stem Cells 2014-2017 ($ Million) 51
Figure CRISPR Market and Growth Rate by Genetically Modified Organisms/Crops 2014-2017 ($ Million) 52
Figure CRISPR Market and Growth Rate by Cell Line Engineering 2014-2017 ($ Million) 52
Figure CRISPR Market and Growth Rate by Biotechnology Companies 2014-2017 ($ Million) 52
Figure CRISPR Market and Growth Rate by Pharmaceutical Companies 2014-2017 ($ Million) 52
Figure CRISPR Market and Growth Rate by Academic Institutes 2014-2017 ($ Million) 52
Figure CRISPR Market and Growth Rate by Research and Development Institutes 2014-2017 ($ Million) 53
Table Merger and Acquisitions 53
Table Transaction Related to CRISPR Technology in 2014 to 2015 55
Table Innovation Status of Key Manufacturers 55
Table Invested Amount ($ Million) of Leading Venture Capital Financed Biotechnology Companies 58
Figure CRISPR Market and Growth Rate by United States 2014-2017 ($ Million) 59
Figure CRISPR Market and Growth Rate by Canada 2014-2017 ($ Million) 59
Figure CRISPR Market and Growth Rate by RoNA (Rest of North America) 2014-2017 ($ Million) 59
Figure CRISPR Market and Growth Rate by United Kingdom 2014-2017 ($ Million) 59
Figure CRISPR Market and Growth Rate by France 2014-2017 ($ Million) 59
Figure CRISPR Market and Growth Rate by Germany 2014-2017 ($ Million) 60
Figure CRISPR Market and Growth Rate by Spain 2014-2017 ($ Million) 60
Figure CRISPR Market and Growth Rate by Italy 2014-2017 ($ Million) 60
Figure CRISPR Market and Growth Rate by RoE (Rest of Europe) 2014-2017 ($ Million) 60
Figure CRISPR Market and Growth Rate by China 2014-2017 ($ Million) 60
Figure CRISPR Market and Growth Rate by Japan 2014-2017 ($ Million) 60
Figure CRISPR Market and Growth Rate by India 2014-2017 ($ Million) 61
Figure CRISPR Market and Growth Rate by Middle East and Africa 2014-2017 ($ Million) 61
Figure CRISPR Market and Growth Rate by Latin America 2014-2017 ($ Million) 61
Table Thermo Fisher Company Basic Information 62
Table Technology/Product Introduction 62
Table CRISPR Expenses (K USD), R&D Expenses (K USD) and R&D Share of Thermo Fisher Scientific 2014-2016 62
Figure CRISPR Expenses (K USD) and Growth Rate of Thermo Fisher Scientific 2014-2016 62
Figure CRISPR Expenses (K USD) and Total Expenses Share of Thermo Fisher Scientific 2014-2016 63
Table Editas Medicine Company Basic Information 63
Table Pipeline of Editas Medicine 63
Table CRISPR Expenses (K USD), R&D Expenses (K USD) and R&D Share of Editas Medicine 2014-2016 64
Figure CRISPR Expenses (K USD) and Growth Rate of Editas Medicine 2014-2016 64
Figure CRISPR Expenses (K USD) and Total Expenses Share of Editas Medicine 2014-2016 64
Table Caribou Biosciences Company Basic Information 64
Table CRISPR Expenses (K USD), R&D Expenses (K USD) and R&D Share of Caribou Biosciences 2014-2016 65
Figure CRISPR Expenses (K USD) and Growth Rate of Caribou Biosciences 2014-2016 65
Figure CRISPR Expenses (K USD) and Total Expenses Share of Caribou Biosciences 2014-2016 65
Table CRISPR therapeutics Company Basic Information 65
Table CRISPR Expenses (K USD), R&D Expenses (K USD) and R&D Share of CRISPR therapeutics 2014-2016 66
Figure CRISPR Expenses (K USD) and Growth Rate of CRISPR therapeutics 2014-2016 66
Figure CRISPR Expenses (K USD) and Total Expenses Share of CRISPR therapeutics 2014-2016 66
Table Intellia therapeutics, Inc. Company Basic Information 66
Table CRISPR Expenses (K USD), R&D Expenses (K USD) and R&D Share of Intellia therapeutics, Inc. 2014-2016 67
Figure CRISPR Expenses (K USD) and Growth Rate of Intellia therapeutics, Inc. 2014-2016 67
Figure CRISPR Expenses (K USD) and Total Expenses Share of Intellia therapeutics, Inc. 2014-2016 67
Table Cellectis Company Basic Information 67
Table CRISPR Expenses (K USD), R&D Expenses (K USD) and R&D Share of Cellectis 2014-2016 68
Figure CRISPR Expenses (K USD) and Growth Rate of Cellectis 2014-2016 68
Figure CRISPR Expenses (K USD) and Total Expenses Share of Cellectis 2014-2016 68
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